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Molecular explanation for the contribution of autophagy to BAT energy metabolism

Obesity is a growing global health problem and its prevalence has tripled since 1975. More than 650 million people are affected by this condition worldwide, and 28% of people in Spain over 18 years of age have this complex pathology. Obesity is linked to conditions such as type II diabetes, cardiovascular disease, osteoarthritis, and certain forms of cancer.

13 Sep 2022

Forecasting COVID-19 surges based on SARS-CoV-2 mutation surveillance

Researchers predicted surges in SARS-CoV-2 infections based on alterations in SARS-CoV-2 mutations.

13 Sep 2022

Study investigates the efficacy and safety of selpercatinib in a diverse group of patients

The highly selective RET inhibitor selpercatinib was well-tolerated and achieved durable objective responses across multiple tumor types in the Phase I/II LIBRETTO-001 trial, according to researchers from The University of Texas MD Anderson Cancer Center.

13 Sep 2022

Treg transplantation improves bone remodeling, study says

The building blocks of a structure consist of load-bearing elements that rarely change despite renovations or repairs. They remain intact and consistent over time, but in the human body, our building blocks do just the opposite.

13 Sep 2022

The impact of the infant gut microbiome on vaccine efficacy

A new study reports the effect of the infant gut microbiome on vaccine efficacy.

13 Sep 2022

Is there a right time for eating?

In a recent study published in the journal Cell Metabolism, researchers assessed how calorie or energy intake (EI) time influences calorie distribution and all energy expenditure (EE) components, which, in turn, impact energy balance and weight loss in healthy obese people.

12 Sep 2022

First report of a SARS-CoV-2 variant with an ORF7a deletion that dominated an outbreak

In a recent study posted to the medRxiv* preprint server, researchers in Australia determined whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta-ORF7aΔ17del [open reading frame 7a protein with 17-nucleotide (nt) frameshift-inducing deletion] variant has a fitness advantage over the Delta variant lacking the ORF7aΔ17del deletion (Delta-ORF7aintact) and/or the SARS-CoV-2 lineage (A.2.2).

12 Sep 2022

SARS-CoV-2 breakthrough infection in vaccinated individuals induces virus-specific nasal T cells of broad specificity

Long-lasting immune cells that specifically recognize the SARS-CoV-2 virus were found in the noses of people who were infected following vaccination.

12 Sep 2022

LJI scientists uncover major clue toward developing new antiviral therapies against flaviviruses

Zika virus has a trick up its sleeve. Once inside the body, the virus likes to make a bee line for dendritic cells, the cells we rely on to launch an effective immune response.

12 Sep 2022

Mucosal vaccination triggers superior T cell response against SARS-CoV-2 variants

In a recent study posted to the bioRxiv* server, researchers in Singapore and the United States demonstrated that intranasal (I.N.) delivery of a mucosal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination triggered a superior T cell response compared to an equivalent dose of antigen delivered by the subcutaneous (S.C.) route.

12 Sep 2022

Antibiotics accelerate metastatic bone growth in mice with melanoma by depleting intestinal flora

The use of broad-spectrum antibiotics in mice with malignant melanoma, an aggressive form of skin cancer, accelerated their metastatic bone growth, likely because the drugs depleted the mice's intestinal flora and weakened their immune response, according to a new study by researchers at Emory University in Atlanta.

12 Sep 2022

Blocking FNDC5 prevents cancer-induced cachexia in mice

The severe muscle atrophy and weakness commonly associated with cancer growth (i.e., cachexia) can be prevented simply by being deprived of FNDC5, the precursor of the exercise hormone irisin, researchers from the Indiana University School of Medicine have found.

12 Sep 2022

Study reveals recommended levels of long-term blood sugar to avoid diabetes-related damage

The levels of long-term blood sugar, HbA1c, can be used to accurately determine the risk of a person with type 1 diabetes developing eye- and kidney complications.

12 Sep 2022

N-dihydrogalactochitosan shows promise as a mucosal vaccine adjuvant against SARS-CoV-2

In a recent study posted to the bioRxiv* server, researchers in the United States demonstrated the efficacy of a novel biopolymer, N-dihydrogalactochitosan (GC), as an adjuvant for next-generation mucosal coronavirus disease 2019 (COVID-19) vaccine.

12 Sep 2022

Researchers uncover the structure of protein fibrils linked to hereditary form of human prion disease

In a new study, researchers from the Case Western Reserve University School of Medicine have identified the structure of protein fibrils linked to a hereditary form of human prion disease.

12 Sep 2022

Phase I/II LIBRETTO-001 trial: RET inhibitor achieves durable objective responses across multiple tumors

12 Sep 2022

Scientists estimate the impact of genetic risk factors on the loss of healthy life years

Researchers have, for the first time, systematically estimated the impact of a range of different disease-associated genetic risk factors on the loss of healthy life years. Knowing the contribution of different genetic risk factors on disease burden can help prioritise and design interventions using genetic information.

12 Sep 2022

Study identifies new therapeutic target against lung adenocarcinoma

The TIMP-1 protein levels in both tissues and blood have been repeatedly associated with a poor prognosis in lung cancers, but its role in this cancer process was, to date, unknown.

12 Sep 2022

Exercise hormone reduces protein levels linked to Parkinson's disease

Researchers from Johns Hopkins Medicine and the Dana Farber Cancer Institute in Boston have shown that a hormone secreted into the blood during endurance, or aerobic, exercise reduces levels of a protein linked to Parkinson's disease and halts movement problems in mice.

12 Sep 2022

Research could lead to a new therapeutic option for patients with bladder cancer

Mount Sinai researchers have made two important discoveries about the mechanism by which bladder cancer cells foil attacks from the immune system.

12 Sep 2022

Protein C News and Research

Molecular explanation for the contribution of autophagy to BAT energy metabolism

Forecasting COVID-19 surges based on SARS-CoV-2 mutation surveillance

Study investigates the efficacy and safety of selpercatinib in a diverse group of patients

Treg transplantation improves bone remodeling, study says

The impact of the infant gut microbiome on vaccine efficacy

Is there a right time for eating?

First report of a SARS-CoV-2 variant with an ORF7a deletion that dominated an outbreak

SARS-CoV-2 breakthrough infection in vaccinated individuals induces virus-specific nasal T cells of broad specificity

LJI scientists uncover major clue toward developing new antiviral therapies against flaviviruses

Mucosal vaccination triggers superior T cell response against SARS-CoV-2 variants

Antibiotics accelerate metastatic bone growth in mice with melanoma by depleting intestinal flora

Blocking FNDC5 prevents cancer-induced cachexia in mice

Study reveals recommended levels of long-term blood sugar to avoid diabetes-related damage

N-dihydrogalactochitosan shows promise as a mucosal vaccine adjuvant against SARS-CoV-2

Researchers uncover the structure of protein fibrils linked to hereditary form of human prion disease

Phase I/II LIBRETTO-001 trial: RET inhibitor achieves durable objective responses across multiple tumors

Scientists estimate the impact of genetic risk factors on the loss of healthy life years

Study identifies new therapeutic target against lung adenocarcinoma

Exercise hormone reduces protein levels linked to Parkinson's disease

Research could lead to a new therapeutic option for patients with bladder cancer

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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