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Certain fragments of DNA shed by tumors can be used to non-invasively screen for early-stage cancers

Certain fragments of DNA shed by tumors into the bloodstream can potentially be used to non-invasively screen for early-stage cancers, monitor responses to treatment and help explain why some cancers are resistant to therapies, according to results of an international study led by Johns Hopkins Kimmel Cancer Center investigators.

20 Feb 2014

UPV/EHU researchers develop method for diagnosis, prognosis of cutaneous melanoma

UPV/EHU researchers have developed a method for the diagnosis and prognosis of cutaneous melanoma, the type of skin cancer with the highest mortality rate.This method will help not only in the more effective early detection of this cancer, but also in the development of more personalised treatments.

20 Feb 2014

Babies who develop leukemia appear to inherit strong genetic predisposition to disease

Babies who develop leukemia during the first year of life appear to inherit an unfortunate combination of genetic variations that can make the infants highly susceptible to the disease, according to a new study at Washington University School of Medicine in St. Louis and the University of Minnesota.

20 Feb 2014

Driver mutations found in more than half of adenosquamous lung carcinomas

Analysis of a large cohort of Chinese patients with adenosquamous lung carcinoma has identified known mutant kinases in more than half of the tumours, researchers report in the Journal of Thoracic Oncology.

19 Feb 2014

Researchers develop method for diagnosis and prognosis of cutaneous melanoma

19 Feb 2014

DFTD study explains how human selection alters evolution of cancerous cells

Tasmanian Devil Facial Tumour Disease (DFTD) has ravaged the world's largest carnivorous marsupial since it emerged in 1996, resulting in a population decline of over 90%.

19 Feb 2014

Sloan Foundation honors 126 outstanding early-career scientists in 8 fields

The Alfred P. Sloan Foundation is pleased to announce the selection of 126 outstanding U.S. and Canadian researchers as recipients of the 2014 Sloan Research Fellowships.

19 Feb 2014

Researchers find new ways to elucidate creation of toxic oligomers associated with Alzheimer's disease

Researchers studying peptides using the Gordon supercomputer at the San Diego Supercomputer Center (SDSC) at the University of California, San Diego (UCSD) have found new ways to elucidate the creation of the toxic oligomers associated with Alzheimer's disease.

19 Feb 2014

Pathway Genomics announces launch of Hereditary Colorectal Cancer DNA Insight genetic test

Pathway Genomics Corporation, a San Diego-based CLIA and CAP accredited clinical laboratory that offers genetic testing services worldwide, today announced the launch of Hereditary Colorectal Cancer DNA Insight, the company's premier hereditary cancer genetic test. Based on a simple saliva sample, the test uses next-generation sequencing (NGS) technology to identify gene alterations or mutations that increase a patient's risk of developing certain types of cancer.

18 Feb 2014

NPS Pharmaceuticals reports net global product sales of $15.3 million for Q4 2013

NPS Pharmaceuticals, Inc., a global biopharmaceutical company pioneering and delivering therapies that transform the lives of patients with rare diseases worldwide, today reported financial results for 2013 and its financial outlook for 2014.

18 Feb 2014

IGF1R linked to mutation-negative lung cancer erlotinib resistance

Activation of the insulin-like growth factor 1 receptor plays a key role in acquired resistance to erlotinib in lung cancer with wild-type epidermal growth factor receptor, research suggests.

18 Feb 2014

Upstream interventions may provide options to contain emerging pathogens at source

While many endemic infectious diseases of humans have been largely contained, new microbes continue to emerge to threaten human and animal health.

18 Feb 2014

Afatinib ‘first line’ for advanced mutation-positive lung cancer

Afatinib should be given as a first-line treatment for Asian patients with advanced, epidermal growth factor receptor mutation-positive, non-small-cell lung cancer, researchers recommend.

17 Feb 2014

Valproic acid metabolism and obesity: an interview with Dr. Namandjé Bumpus, Johns Hopkins Medicine

Valproic acid is one of the most widely prescribed drugs for the treatment of epilepsy. It has also been shown to be effective for the treatment of mood disorders and migraine headaches.

17 Feb 2014

Scientists develop new paradigms for understanding how human brain works in health, disease

Understanding the human brain is one of the greatest challenges facing 21st century science. If we can rise to this challenge, we will gain profound insights into what makes us human, develop new treatments for brain diseases, and build revolutionary new computing technologies that will have far reaching effects, not only in neuroscience.

17 Feb 2014

Research provides new insight into the effect of misfolded proteins in neurodegenerative disorders

Research by the University of Southampton has provided new insight into the consequence of accumulated 'misfolded proteins' in neurodegenerative disorders, such as Prion and Alzheimer's disease.

16 Feb 2014

New study documents frequency of EGFR mutations in lung adenocarcinoma in Asian population

Adenocarcinoma histology, female sex, never-smoking status, and Asian ethnicity have been considered the most important factors associated with EGFR mutations in non-small cell lung cancer and response to EGFR inhibitors. A recent study has found that, within the Asian population, the frequency of EGFR mutations associated with other demographic and clinical characteristics is higher than previously reported, even in patients with a history of smoking, suggesting that mutation testing should be done on a broader basis among Asian patients with advanced adenocarcinoma of the lung.

16 Feb 2014

Mutation News and Research

Certain fragments of DNA shed by tumors can be used to non-invasively screen for early-stage cancers

UPV/EHU researchers develop method for diagnosis, prognosis of cutaneous melanoma

Babies who develop leukemia appear to inherit strong genetic predisposition to disease

Driver mutations found in more than half of adenosquamous lung carcinomas

Researchers develop method for diagnosis and prognosis of cutaneous melanoma

DFTD study explains how human selection alters evolution of cancerous cells

Sloan Foundation honors 126 outstanding early-career scientists in 8 fields

Researchers find new ways to elucidate creation of toxic oligomers associated with Alzheimer's disease

Pathway Genomics announces launch of Hereditary Colorectal Cancer DNA Insight genetic test

NPS Pharmaceuticals reports net global product sales of $15.3 million for Q4 2013

IGF1R linked to mutation-negative lung cancer erlotinib resistance

Upstream interventions may provide options to contain emerging pathogens at source

Afatinib ‘first line’ for advanced mutation-positive lung cancer

Valproic acid metabolism and obesity: an interview with Dr. Namandjé Bumpus, Johns Hopkins Medicine

Scientists develop new paradigms for understanding how human brain works in health, disease

Research provides new insight into the effect of misfolded proteins in neurodegenerative disorders

New study documents frequency of EGFR mutations in lung adenocarcinoma in Asian population

Old FDA-approved drugs may hold promise for treatment of rare, drug-resistant cancer

Researchers receive funding to develop treatments for Rett Syndrome

Researchers find 'missing' genetic risk in cancer

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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