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Researchers personalize drug treatments for cholangiocarcinoma using genomic sequencing

Physicians at Mayo Clinic's Individualized Medicine Clinic and researchers at the Translational Genomics Research Institute (TGen) have personalized drug treatments for patients with cholangiocarcinoma using genomic sequencing technologies.

14 Feb 2014

Common mutations produce typical schizophrenia brain changes

Mutations in dopamine-related genes have a dose-response effect on prefrontal activation during emotional response inhibition in healthy adults, a study shows.

13 Feb 2014

Researchers discover pre-leukemic stem cell that triggers relapse in patients with AML

Cancer researchers led by stem cell scientist Dr. John Dick have discovered a pre-leukemic stem cell that may be the first step in initiating disease and also the culprit that evades therapy and triggers relapse in patients with acute myeloid leukemia (AML).

13 Feb 2014

Study shows benefit of double mastectomy in women with BRCA-related breast cancer

Women with BRCA-related breast cancer who have a double mastectomy are nearly 50 per cent less likely to die of breast cancer within 20 years of diagnosis compared to women who have a single mastectomy, according to a new study led by Women's College Hospital's Kelly Metcalfe.

12 Feb 2014

Scientists explain why women with dense breast tissue at greater risk of developing breast cancer

Scientists from The University of Manchester working with IBM Research have identified a key biological mechanism that for the first time explains why women with dense breast tissue are at greater risk of developing breast cancer.

12 Feb 2014

Understanding genetic changes associated with aggressive prostate cancer

Researchers at the University of East Anglia have made an important advance in understanding genetic changes associated with terminal prostate cancer.

12 Feb 2014

Researchers examine how evolution relates to health

February 12 marks the birth of the 19th century naturalist Charles Darwin, who launched the scientific study of evolution. While Darwin's theory laid the groundwork, ongoing studies have deepened our understanding of evolution, including how it relates to health. Research funded by the National Institutes of Health has helped answer many questions about evolution, health and medicine. Here's a sampling.

12 Feb 2014

RNA interference approach holds great promise for treating cancer and other diseases

Inspired by tiny particles that carry cholesterol through the body, MIT chemical engineers have designed nanoparticles that can deliver snippets of genetic material that turn off disease-causing genes.

12 Feb 2014

U-shaped association between paternal age and bipolar risk

Having a father who is relatively young or old may increase a person’s risk of developing bipolar disorder, a study suggests.

11 Feb 2014

Combination of SYK and FLT3 enzymes promotes progression of acute myelogenous leukemia

Reinforcing the need to look beyond genomic alterations to understand the complexity of cancer, researchers from Dana-Farber/Boston Children's Cancer and Blood Disorders Center report that a normal enzyme called SYK pairs with FLT3, the most commonly mutated enzyme found in acute myelogenous leukemia (AML), to promote progression of the disease.

11 Feb 2014

GenomOncology collaborates with RPCI to develop informatics solution for Next Generation Sequencing

GenomOncology today announced a collaboration with Roswell Park Cancer Institute (RPCI) to develop an informatics solution that enables the association of Next Generation Sequencing results with knowledge resources to define actionable mutations.

11 Feb 2014

Scientists identify gene linking thickness of grey matter in brain to intelligence

For the first time, scientists at King's College London have identified a gene linking the thickness of the grey matter in the brain to intelligence. The study is published today in Molecular Psychiatry and may help scientists understand biological mechanisms behind some forms of intellectual impairment.

11 Feb 2014

EKF Molecular Diagnostics to exhibit PointMan DNA-enrichment technology at Tri-Con 2014

EKF, announces that its subsidiary company EKF Molecular Diagnostics is exhibiting its ground-breaking PointMan DNA-enrichment tech.

From EKF Diagnostics 11 Feb 2014

Researchers promote scientific and health prevention culture among national population

The Mexican enterprise "Science that breathes" is supported by the National Institutes of Respiratory Diseases and Carcinology among others.

11 Feb 2014

Mayo Clinic researchers shed light on new mechanism by which prostate cancer develops in men

Mayo Clinic researchers have shed light on a new mechanism by which prostate cancer develops in men. Central to development of nearly all prostate cancer cases are malfunctions in the androgen receptor - the cellular component that binds to male hormones.

11 Feb 2014

Researchers find biological weakness in the workings of mutated gene involved in human cancers

NYU Langone Medical Center researchers have found a biological weakness in the workings of the most commonly mutated gene involved in human cancers, known as mutant K-Ras, which they say can be exploited by drug chemotherapies to thwart tumor growth.

10 Feb 2014

Findings may help physicians choose precise treatments for women with advanced breast cancer

The first large-scale study testing all the DNA—the entire genome—of tumour cells from more than 400 women with advanced breast cancer has identified individuals with a good chance of benefiting from specific treatments already being tested in clinical trials.

10 Feb 2014

New study tracks spread of H5N1 variant in Egypt recently identified as major epicenter for virus

Since its first identification in Asia, highly pathogenic avian influenza-H5N1-has caused significant alarm in the scientific community. While the virus' primary target is birds-tens of millions have already died from it-it is capable of infecting mammals, including humans, causing serious illness and a frightening rate of mortality.

10 Feb 2014

Researchers examine link between gender and genetic disorder

A genetic disorder that affects about 1 in every 2,500 births can cause a bewildering array of clinical problems, including brain tumors, impaired vision, learning disabilities, behavioral problems, heart defects and bone deformities. The symptoms and their severity vary among patients affected by this condition, known as neurofibromatosis type 1 (NF1).

9 Feb 2014

Study points to molecular pathway to treat recurring, deadly malignancies

Analyzing the genomes of twin 3-year-old sisters – one healthy and one with aggressive leukemia – led an international team of researchers to identify a novel molecular target that could become a way to treat recurring and deadly malignancies.

9 Feb 2014

Mutation News and Research

Researchers personalize drug treatments for cholangiocarcinoma using genomic sequencing

Common mutations produce typical schizophrenia brain changes

Researchers discover pre-leukemic stem cell that triggers relapse in patients with AML

Study shows benefit of double mastectomy in women with BRCA-related breast cancer

Scientists explain why women with dense breast tissue at greater risk of developing breast cancer

Understanding genetic changes associated with aggressive prostate cancer

Researchers examine how evolution relates to health

RNA interference approach holds great promise for treating cancer and other diseases

U-shaped association between paternal age and bipolar risk

Combination of SYK and FLT3 enzymes promotes progression of acute myelogenous leukemia

GenomOncology collaborates with RPCI to develop informatics solution for Next Generation Sequencing

Scientists identify gene linking thickness of grey matter in brain to intelligence

EKF Molecular Diagnostics to exhibit PointMan DNA-enrichment technology at Tri-Con 2014

Researchers promote scientific and health prevention culture among national population

Mayo Clinic researchers shed light on new mechanism by which prostate cancer develops in men

Researchers find biological weakness in the workings of mutated gene involved in human cancers

Findings may help physicians choose precise treatments for women with advanced breast cancer

New study tracks spread of H5N1 variant in Egypt recently identified as major epicenter for virus

Researchers examine link between gender and genetic disorder

Study points to molecular pathway to treat recurring, deadly malignancies

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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