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Clovis commences CO-1686 Phase I/II study in NSCLC

Clovis Oncology, Inc. announced today that the first clinical study of CO-1686 has commenced with the dosing of the first patient at a U.S. study site. CO-1686 is a novel, oral, targeted covalent inhibitor of epidermal growth factor receptor (EGFR) mutations currently being studied for the treatment of non-small cell lung cancer.

29 Mar 2012

Conservative justices appear skeptical of health law's insurance mandate

In today's oral arguments, the second day of action at the Supreme Court,the individual mandate was the focus of a barrage of tough questions.

28 Mar 2012

Day 1 & 2: Citizens gather as Supreme Court begins review of health law (slideshow)

Inside the Supreme Court building this week, the nation's highest court is hearing oral arguments in a case that seeks to overturn the 2010 health law.

28 Mar 2012

Demonstrators provide punctuation, personality to ongoing debate

Though events inside the Supreme Court were staid and steeped in the high court's rules and processes, outside activists converged to argue their positions and to shape public opinion about the health law.

28 Mar 2012

First Edition: March 28, 2012

Today's headlines recap yesterday's Supreme Court action related to the constitutionality of the individual mandate and set the scene for day 3 of the oral arguments, which will tackle issues of severalbility and questions about the health law's Medicaid expansion.

28 Mar 2012

States continue epic struggle over what the health law means for them

Minnesota GOP lawmakers are being criticized by their Democratic governor for how they are trying to create a health insurance exchange. Elsewhere, California insurance rates are increasing as the Supreme Court hears arguments on the health law and a pair of protests targets the health law and unions in Missouri.

28 Mar 2012

What individual mandate, other health law rulings may mean for Americans

News outlets analyze arguments around the individual mandate and what a ruling by the Supreme Court will mean for most Americans. Kaiser Health News looks at changes in the health care industry as a result of the law, and how most of those shifts will continue regardless of what the Court decides.

28 Mar 2012

As court brings health overhaul into focus, politicians pounce

Rick Santorum picks up his criticism of Mitt Romney's efforts in Massachusetts, which set up mandatory health coverage, but the former governor continues to assail the federal plan.

28 Mar 2012

High court unlikely to push health law ruling into the future

Based on justices questions' during the opening day of oral arguments in the challenges to the health law, it appears the court was receptive to arguments by both the federal government and the measure's opponents that the case should be decided now rather than waiting until after the individual mandate's penalties for not having health insurance have kicked in.

28 Mar 2012

UofL researcher receives patent for novel biochemical discovery

University of Louisville researchers are a step closer to eliminating periodontal disease through their work to develop synthetic molecules that prevent a bacteria responsible for the disease from spreading throughout the mouth.

28 Mar 2012

If it's Tuesday, it's the individual mandate

In the second day of oral arguments, the Supreme Court is considering the "individual mandate," which is considered the "heart" of the health law. The issue is steeped in politics.

28 Mar 2012

UM completes most extensive full vascularized composite allograft to date

The University of Maryland released details today of the most extensive full face transplant completed to date, including both jaws, teeth, and tongue.

28 Mar 2012

First clinical trial to evaluate intravenous antibiotics for CF lung infection

Experts from Bristol and Nottingham are leading a major new national study to investigate whether intravenous antibiotics are effective in killing a common germ that causes dangerous complications in cystic fibrosis (CF) patients.

28 Mar 2012

Viewpoints on health law: Court decision will determine federal role 'in caring' for people; Law is scaring business

The Supreme Court's epic oral arguments on the constitutionality of the Affordable Care Act began Monday with a kind of tease. The 90-minute exchange explored a technical side issue about taxes, but even so it suggested that the Justices will rule on the merits and are skeptical of some of the Obama Administration's claims.

28 Mar 2012

ECTS, IOF publish guidance document to manage GIO

Oral glucocorticoids are commonly prescribed for a wide variety of disorders, most commonly for rheumatoid arthritis, obstructive pulmonary disease and inflammatory bowel diseases. However, the use of these medications can result in rapid bone loss during the first three to six months of therapy, leading to increased risk of fragility fractures.

28 Mar 2012

Specific precautions must be taken for individuals on longer-term oral glucocorticoid therapy

Millions of people around the world are prescribed glucocorticoids for a wide variety of inflammatory conditions, including, rheumatoid arthritis, asthma and inflammatory bowel diseases. Although they are effective and widely used, one of the potentially serious side effects of these medications is glucocorticoid-induced osteoporosis.

28 Mar 2012

Mount Sinai researchers present 86 abstracts and plenary sessions at ACC meeting

Mount Sinai School of Medicine researchers presented 86 abstracts and plenary sessions at the American College of Cardiology's (ACC) 61st Annual Scientific Session, including ground-breaking research on aggressive statin therapy, the prevalence of unrecognized cardiovascular disease symptoms in women, and morbidity associated with non-adherence to medication after stent implantation. The meeting took place March 23-27, 2012 in Chicago.

28 Mar 2012

Researchers develop gut-on-a-chip microdevice

Researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University have created a gut-on-a-chip microdevice lined by living human cells that mimics the structure, physiology, and mechanics of the human intestine-even supporting the growth of living microbes within its luminal space.

28 Mar 2012

Top-line results from two Targacept TC-6987 Phase 2 studies on asthma, type 2 diabetes

Targacept, Inc., a clinical-stage biopharmaceutical company developing novel NNR Therapeutics, today announced top-line results from two separate exploratory Phase 2 studies of its product candidate TC-6987 conducted in the United States, one in asthma and one in type 2 diabetes.

28 Mar 2012

Rivaroxaban found safe and effective in pulmonary embolism

Rivaroxaban has been found to be effective in the prevention of venous thromboembolism (VTE) after orthopedic surgery, for the prevention of stroke in AF (Atrial fibrillation) patients, and as additional therapy to conventional antiplatelet therapy in ACS (Acute coronary syndrome) patients.

27 Mar 2012