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CTI announces initiation of pacritinib Phase 2 trial in AML patients with FLT3 mutations

Cell Therapeutics, Inc. today announced the initiation of an international cooperative group Phase 2 clinical trial of pacritinib in adult patients with relapsed acute myeloid leukemia (AML) with mutations of the FLT3 gene. Mutation of the FLT3 gene is found in approximately one-third of AML patients and is an independent risk factor for poor prognosis.

30 Jan 2014

TCGA Research Network identify new potential therapeutic targets for major form of bladder cancer

Investigators with The Cancer Genome Atlas (TCGA) Research Network have identified new potential therapeutic targets for a major form of bladder cancer, including important genes and pathways that are disrupted in the disease.

30 Jan 2014

Findings on molecular defects behind bladder cancer may pave way for new, targeted treatments

The once sketchy landscape of the molecular defects behind bladder cancer now resembles a road map to new, targeted treatments thanks to the unified efforts of scientists and physicians at 40 institutions.

30 Jan 2014

Researcher receives 2014 Japan Prize in Life Sciences for extraordinary work in the field of epigenetics

C. David Allis, a pioneer in the field of epigenetics whose discovery that chemical modifications of DNA-packaging proteins play a key role in regulating the activity of individual genes, will be awarded the 2014 Japan Prize in Life Sciences. The announcement, by the Japan Prize Foundation, was made at a press conference in Tokyo this morning.

29 Jan 2014

Study: Genetic mutations in titin gene can cause skeletal muscle disease

A University of Arizona doctoral candidate has shown for the first time that genetic mutations in the titin gene can cause skeletal muscle myopathy, a disease in which muscle fibers do not function properly, resulting in muscle weakness.

29 Jan 2014

Transgenic mouse model validates mutant IDH2 protein as candidate for targeted anticancer therapies

In recent years, mutations in two metabolic enzymes, isocitrate dehydrogenase-1 and 2 (IDH1 and IDH2), have been identified in approximately 20 percent of all acute myeloid leukemias (AML). As a result, mutant IDH proteins have been proposed as attractive drug targets for this common form of adult leukemia.

29 Jan 2014

Johns Hopkins researchers reveal how non-CpG methylation may contribute to Rett Syndrome

In normal development, all cells turn off genes they don’t need, often by attaching a chemical methyl group to the DNA, a process called methylation. Historically, scientists believed methyl groups could only stick to a particular DNA sequence: a cytosine followed by a guanine, called CpG. But in recent years, they have been found on other sequences, and so-called non-CpG methylation has been found in stem cells, and in neurons in the brain.

28 Jan 2014

Top-line results from two Phase 3 studies of dacomitinib for patients with advanced NSCLC published

Pfizer Inc. today announced top-line results from two randomized Phase 3 studies of the irreversible pan-HER kinase inhibitor dacomitinib in patients with advanced non-small cell lung cancer.

28 Jan 2014

GenePeeks receives patent for developing innovative algorithms to create hypothetical "digital babies"

GenePeeks, Inc., a genetic technology company focused on pre-conception risk prediction, announced today it has been issued patent No. 8,620,594, titled "Method and System for Generating a Virtual Progeny Genome," by the United States Patent and Trademark Office.

28 Jan 2014

BRAF mutations rare in Japanese NSCLC patients

Research in a Japanese cohort of patients with non-small-cell lung cancer indicates that the frequency of BRAF mutations is low and their presence has limited prognostic significance.

27 Jan 2014

South Korean lung SCC genetic secrets revealed

Close examination of DNA taken from squamous cell carcinoma of the lung in South Korean patients has identified a gene fusion that may be targeted by current treatments, scientists say.

27 Jan 2014

New method allows for large-scale generation of human embryonic stem cells

A new method allows for large-scale generation of human embryonic stem cells of high clinical quality. It also allows for production of such cells without destroying any human embryos.

27 Jan 2014

Large-scale analysis of over 20 tumor types increases catalog of cancer genes by 25%

A landmark study across many cancer types reveals that the universe of cancer mutations is much bigger than previously thought. By analyzing the genomes of thousands of patients' tumors, a Broad Institute-led research team has discovered many new cancer genes - expanding the list of known genes tied to these cancers by 25 percent. Moreover, the study shows that many key cancer genes still remain to be discovered.

25 Jan 2014

Scientists develop powerful RapidCaP mouse models for metastatic prostate cancer

Prostate cancer is the most common form of cancer in men. Affecting about 1 in 6 men, it is the second deadliest cancer. Research has been stymied by imperfect animal models of the disease, which are costly, take considerable time to develop, and fail to mimic the most lethal aspects of the illness.

25 Jan 2014

Novel HER2 mutation identified in familial lung adenocarcinomas

Researchers have identified a novel germline mutation in the transmembrane domain of the human epidermal growth factor receptor 2 gene in familial lung adenocarcinomas.

24 Jan 2014

Scientists identify genetic alterations in pediatric soft-tissue cancer

Scientists have mapped the genetic changes that drive tumors in rhabdomyosarcoma, a pediatric soft-tissue cancer, and found that the disease is characterized by two distinct genotypes. The genetic alterations identified in this malignancy could be useful in developing targeted diagnostic tools and treatments for children with the disease. The study, by researchers at the National Cancer Institute, part of the National Institutes of Health, and their colleagues, appeared in the Jan. 23, 2014, issue of the journal Cancer Discovery.

24 Jan 2014

Early onset of dietary treatment may slow down progression of Alzheimer's disease

New research findings indicate that an early onset of dietary treatment may slow down the progression of Alzheimer's disease. The study was conducted on mice, and the results will be published in the February issue of Journal of Nutritional Biochemistry. Researchers from the University of Eastern Finland played a key role in the study, which was carried out as part of the LiPiDiDiet project funded by the European Union.

24 Jan 2014

Scientists aim to develop business plan to guide drug development for potential use in patients

What if an experimental treatment for an aggressive breast cancer had the potential to save women's lives, but nobody could use it because there was no money to develop and test it? With funding sources for research and development more scarce than in the past, it is not an unusual situation. It's a problem that Sourav Sinha, a Master's degree candidate at Rutgers' Graduate School of Biomedical Sciences, is working to tackle head-on.

24 Jan 2014

Researchers reveal how genetic susceptibility plays large role in cancer risk

In laboratory experiments conducted on human cell lines at the Johns Hopkins Kimmel Cancer Center, scientists have shown that people carrying certain mutations in two hereditary cancer genes, BRCA2 and PALB2, may have a higher than usual susceptibility to DNA damage caused by a byproduct of alcohol, called acetaldehyde.

24 Jan 2014

Moderate radiation doses can kill premalignant cells and prevent second breast cancers

Survivors of breast cancer have a one in six chance of developing breast cancer in the other breast. But a study conducted in mice suggests that survivors can dramatically reduce that risk through treatment with moderate doses of radiation to the unaffected breast at the same time that they receive radiation therapy to their affected breast.

24 Jan 2014

Mutation News and Research

CTI announces initiation of pacritinib Phase 2 trial in AML patients with FLT3 mutations

TCGA Research Network identify new potential therapeutic targets for major form of bladder cancer

Findings on molecular defects behind bladder cancer may pave way for new, targeted treatments

Researcher receives 2014 Japan Prize in Life Sciences for extraordinary work in the field of epigenetics

Study: Genetic mutations in titin gene can cause skeletal muscle disease

Transgenic mouse model validates mutant IDH2 protein as candidate for targeted anticancer therapies

Johns Hopkins researchers reveal how non-CpG methylation may contribute to Rett Syndrome

Top-line results from two Phase 3 studies of dacomitinib for patients with advanced NSCLC published

GenePeeks receives patent for developing innovative algorithms to create hypothetical "digital babies"

BRAF mutations rare in Japanese NSCLC patients

South Korean lung SCC genetic secrets revealed

New method allows for large-scale generation of human embryonic stem cells

Large-scale analysis of over 20 tumor types increases catalog of cancer genes by 25%

Scientists develop powerful RapidCaP mouse models for metastatic prostate cancer

Novel HER2 mutation identified in familial lung adenocarcinomas

Scientists identify genetic alterations in pediatric soft-tissue cancer

Early onset of dietary treatment may slow down progression of Alzheimer's disease

Scientists aim to develop business plan to guide drug development for potential use in patients

Researchers reveal how genetic susceptibility plays large role in cancer risk

Moderate radiation doses can kill premalignant cells and prevent second breast cancers

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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