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Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain could guide design of antiviral agents

The outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 virus continues to cause human infection and mortality worldwide. Currently, there are no specific viral protein-targeted therapeutics available.

20 Oct 2020

Study findings may help identify new targets to inhibit spread of melanoma

Research led by Queen Mary University of London has revealed novel insights into the mechanisms employed by melanoma cells to form tumors at secondary sites around the body.

20 Oct 2020

Template for COVID-19 management in a rural health system

As the COVID-19 pandemic continues to challenge existing health networks, a new study published on the preprint server medRxiv in October 2020 reports on a strategy to address existing health care disparities in rural and urban areas of the USA. This should draw attention to the need for more such systems to ensure proper rural healthcare in the current and future pandemics.

20 Oct 2020

Study reports children with chronic kidney disease may spend more time in hospital

Chronically ill children with kidney disease may spend more time in the hospital, incur larger health care costs, and have a higher risk of death compared to pediatric patients hospitalized for other chronic conditions, a new study suggests.

20 Oct 2020

Study shows concerning levels of COVID-19 vaccine hesitancy

More than a third of people (34%) in Turkey and one sixth of people (17%) in the UK are 'hesitant' about a COVID-19 vaccine, according to a study by UCL and Dokuz Eylul University in Turkey.

20 Oct 2020

New inhaled treatment may lead to self-administered therapy for COVID-19

An inhaled treatment against the SARS-CoV-2 virus may lead to a future self-administered therapy for COVID-19, the pandemic that has killed more than 1 million people worldwide.

20 Oct 2020

Design of an mRNA SARS-CoV-2 vaccine encapsulated in lipid nanoparticles

Now, a new study presented on the preprint server bioRxiv in October 2020 describes the efficient design of an mRNA vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), based on the use of the viral receptor-binding domain (RBD) mRNA encapsulated in lipid nanoparticles (LNP).

19 Oct 2020

Scientists find striking acceleration in medieval plague transmission over 300 years

McMaster University researchers who analyzed thousands of documents covering a 300-year span of plague outbreaks in London, England, have estimated that the disease spread four times faster in the 17th century than it had in the 14th century.

19 Oct 2020

Trend analysis in Japan reveals Creutzfeldt-Jakob disease may not be so rare anymore

Creutzfeldt-Jakob disease (CJD) is a debilitating disorder that causes rapid degeneration of the brain as well as progressing dementia.

19 Oct 2020

COVID-19 has increased the urgency of advanced care planning, WVU study shows

No one likes to think about their own mortality. But COVID-19 has shoved life's dark questions to the forefront: "What if I'm hooked to a ventilator and can't speak?" "If my heart stops beating, do I want to be resuscitated?" "Where do I want to die?"

19 Oct 2020

Melatonin may increase survival chances among intubated COVID-19 patients

Researchers at Columbia University in New York have conducted a study showing that patients with coronavirus disease 2019 (COVID-19) who require intubation and mechanical ventilation due to respiratory distress may benefit from treatment with the hormone melatonin.

19 Oct 2020

Temple researchers identify criteria to predict cytokine storm in COVID-19 patients

Like a cold front that moves in, setting the stage for severe weather, coronavirus infection triggers showers of infection-fighting immune molecules - showers that sometimes escalate into a chaotic immune response known as a cytokine storm.

19 Oct 2020

Immunoglobulin M ACE2 autoantibodies associated with severe COVID-19

As the COVID-19 pandemic progresses with little prospect of immediate relief, a recent study by Johns Hopkins University researchers published on the preprint server medRxiv* in October 2020 discusses the association of Immunoglobulin M (IgM) autoantibodies against the host receptor that binds severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with severe disease via vascular endothelial damage. This could help develop better therapies and prognostic criteria.

19 Oct 2020

Study: Sea lions have largest negative impact on early-arriving endangered Chinook salmon

The Columbia River is home to one of the West Coast's most important Chinook salmon runs. Through late spring and early summer, mature fish return from the sea and begin their arduous journey upriver to spawn.

19 Oct 2020

WHO study finds Remdesivir and other repurposed drugs ineffective in COVID-19

A large-scale randomized trial has recently been conducted by the World Health Organization (WHO) to evaluate the efficacy of four repurposed antiviral medicines, including Remdesivir, Hydroxychloroquine, Lopinavir, and Interferon, currently used to treat hospitalized coronavirus disease 2019 (COVID-19) patients.

18 Oct 2020

Obesity changes ACE2 and TMPRSS2 expression in mice: Implications for COVID-19

Researchers studying young obese mice found that expression of ACE2, a receptor in host cells that binds to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is higher in the lungs and trachea of obese mice. The finding could partly explain why obesity is a high-risk factor for COVID-19.

18 Oct 2020

Mortality News and Research

Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain could guide design of antiviral agents

Study findings may help identify new targets to inhibit spread of melanoma

Template for COVID-19 management in a rural health system

Study reports children with chronic kidney disease may spend more time in hospital

Study shows concerning levels of COVID-19 vaccine hesitancy

New inhaled treatment may lead to self-administered therapy for COVID-19

Design of an mRNA SARS-CoV-2 vaccine encapsulated in lipid nanoparticles

Scientists find striking acceleration in medieval plague transmission over 300 years

Trend analysis in Japan reveals Creutzfeldt-Jakob disease may not be so rare anymore

COVID-19 has increased the urgency of advanced care planning, WVU study shows

Melatonin may increase survival chances among intubated COVID-19 patients

Temple researchers identify criteria to predict cytokine storm in COVID-19 patients

Immunoglobulin M ACE2 autoantibodies associated with severe COVID-19

Study: Sea lions have largest negative impact on early-arriving endangered Chinook salmon

WHO study finds Remdesivir and other repurposed drugs ineffective in COVID-19

Obesity changes ACE2 and TMPRSS2 expression in mice: Implications for COVID-19

Study examines how international travel restrictions have affected COVID-19 mortality

Plant genetic engineering to sustainably address micronutrient malnutrition

NIH launches adaptive Phase 3 clinical trial to test immune modulator drugs in COVID-19 patients

Control trial proves effectiveness of repurposed drugs for COVID-19 treatment

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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