Swiss data shows COVID-19 three times more deadly than the flu

The COVID-19 pandemic has caused a massive health, socio-economic, and financial crisis across the world. Without a preventive or curative solution against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it will continue to impact public health and life globally. Despite this, COVID-19 is often downplayed to be only a seasonal flu by many. This may be because both influenza and COVID-19 have a similar initial presentation, and it is tough to distinguish between the two based on just the clinical presentation.

Is COVID-19 similar to the seasonal influenza?

The virus's characteristics and the disease course in COVID-19 are far more serious than the flu in many aspects. Unlike the flu, SARS-CoV-2 seems to be more contagious and has a reproductive number of 2-2.5. It is contagious even when patients have no symptoms or even before they start showing symptoms.

While the common symptoms of both these infections are cough, fever, or headache, COVID-19 is more deadly in many aspects than the seasonal flu, as is evident from the toll it has taken and the number of lives it has impacted globally. COVID-19 has overwhelmed health care systems in many countries, with ICUs reaching their limits and people with other diseases unable to get treated due to limited resources. Many countries resorted to nation-wide lockdowns to slow down the spread of COVID-19, leading to an unprecedented economic breakdown. Many countries are reeling under a harsher second wave of the pandemic as we speak.

Comparing the clinical outcomes of COVID-19 and seasonal influenza

To date, only a few studies have attempted to compare the clinical outcomes of COVID-19 and influenza, and they found that underlying conditions in patients impact the disease course of both the infections. However, the small sample size of these studies makes it tough to draw tangible conclusions.

Given the significance of the comparison of seasonal influenza and COVID-19 from a public health perspective, a team of researchers from several institutions in Switzerland and Germany set out to investigate the differences in ICU admission and mortality among patients hospitalized with influenza COVID-19 disease in Switzerland. Their study is published on the preprint server medRxiv*.

As per previous estimates, nearly 5,000 patients with seasonal flu infection need hospitalization, and about 1,500 patients die due to seasonal influenza every year in Switzerland. In comparison, COVID-19 has already infected over 285,000 people in Switzerland, with 11,229 hospitalizations and 3,879 deaths as of 19th  November 2020.

Cumulative incidence plot. Mortality with discharge as competing risk, by disease status (COVID-19 versus influenza)
Cumulative incidence plot. Mortality with discharge as competing risk, by disease status (COVID-19 versus influenza)

Differences in ICU admission and mortality among hospitalized COVID-19 and influenza patients

The study cohort included patients over 18 years of age with PCR positive COVID-19 or seasonal influenza infection and admitted to 14 participating Swiss hospitals. Primary and secondary outcomes were in-hospital mortality and ICU admission between seasonal flu and COVID-19 patients. 2,843 COVID-19 patients were included from 14 centers in 2020, while 1,361 influenza patients were recruited in 7 centers between 2018 and 2020.

The results showed that COVID-19 patients were predominantly male and were younger (median age 67 years) compared to influenza patients who were predominantly female and older (median age 74 years). The team found that 12.8% or 363 COVID-19 patients died in the hospital compared to 4.4% or 61 influenza patients who were part of the study.

Cumulative incidence plot. ICU admission with discharge and death before ICU admission as competing risk, by disease status (COVID-19 versus influenza)
Cumulative incidence plot. ICU admission with discharge and death before ICU admission as competing risk, by disease status (COVID-19 versus influenza)

COVID-19 patients had 3-fold more cumulative risk of mortality than influenza patients

This study compared the clinical outcomes of hospitalized influenza or COVID-19 patients from a Swiss surveillance database. After accounting for competing events and imbalances among patient groups, COVID-19 patients had a 3-fold more cumulative risk of mortality in-hospital compared to influenza patients. This agrees with WHO estimates of fatality rates of COVID-19 (3-4%) and seasonal influenza (0.1%).

COVID-19 patients also had an increased daily mortality risk and an increased duration of stay in hospital. Similarly, COVID-19 patients were at over 2-fold increased risk of being transferred to an ICU compared to influenza patients.

Based on these findings, the authors concluded that even in a well-equipped healthcare system with sufficient resources, COVID-19 was associated with worse outcomes than influenza, as the risk of ICU admission and in-hospital death were ~3-fold higher in COVID-19 patients.

"Even in a national healthcare system with sufficient human and financial resources, community-acquired COVID-19 was associated with worse outcomes compared to community-acquired influenza, as the hazards of in-hospital death and ICU admission were ~3-fold higher."

*Important Notice

medRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information.

Sources:
Journal reference:
  • COVID-19: more than a little flu? Insights from the Swiss hospital-based surveillance of Influenza and COVID-19 Georg Froehlich, Marlieke De Kraker, Mohammed Abbas, Olivia Keiser, Amaury Thiabaud, Maroussia Roulens, Alexia Cusini, Domenica Flury, Peter Schreiber, Michael Buettcher, Natascia Corti, Danielle Vuichard-Gysin, Nicolas Troillet, Julien Sauser, Roman Gaudenz, Lauro Damonti, Carlo Balmelli, Anne Iten, Andreas Widmer, Stephan Harbarth, Rami Sommerstein, medRxiv, 2020.11.17.20233080; doi: https://doi.org/10.1101/2020.11.17.20233080, https://www.medrxiv.org/content/10.1101/2020.11.17.20233080v1
Susha Cheriyedath

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Susha Cheriyedath

Susha has a Bachelor of Science (B.Sc.) degree in Chemistry and Master of Science (M.Sc) degree in Biochemistry from the University of Calicut, India. She always had a keen interest in medical and health science. As part of her masters degree, she specialized in Biochemistry, with an emphasis on Microbiology, Physiology, Biotechnology, and Nutrition. In her spare time, she loves to cook up a storm in the kitchen with her super-messy baking experiments.

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