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Researchers develop dynamic smart drug that targets site-specific inflammation

Ben-Gurion University of the Negev and University of Colorado researchers have developed a dynamic "smart" drug that targets inflammation in a site-specific manner and could enhance the body's natural ability to fight infection and reduce side effects.

23 Jul 2015

Study reveals potential new therapeutic target for depression treatment

Increasing the levels of a signaling molecule found in the brain can positively alter response to stress, revealing a potential new therapeutic target for treatment of depression, UT Southwestern Medical Center researchers said.

22 Jul 2015

MetLife Foundation Awards for Medical Research presented at AAIC 2015

At the Alzheimer's Association International Conference 2015 in Washington D.C., MetLife Foundation presented its annual MetLife Foundation Awards for Medical Research. These awards were presented to Randall Bateman, M.D., and Christian Haass, Ph.D., for their contributions in advancing Alzheimer's disease research.

21 Jul 2015

Researchers find evidence that directly links disrupted metabolism to fatal type of lymphoma

Researchers from the School of Medicine at The University of Texas Health Science Center at San Antonio have found evidence that directly links disrupted metabolism (energy production in cells) to a common and often fatal type of lymphoma.

20 Jul 2015

Scientists find potent agent that thwarts drug resistance in malaria parasite

Scientists have made an important breakthrough in the fight against malaria, identifying a potent agent that thwarts drug resistance in the parasite that causes the disease.

20 Jul 2015

UT Southwestern researchers find potential therapy to treat diabetes, nonalcoholic fatty liver disease

Reducing high concentrations of a fatty molecule that is commonly found in people with diabetes and nonalcoholic fatty liver disease rapidly improves insulin sensitivity, UT Southwestern Medical Center diabetes researchers have found.

17 Jul 2015

AESKU.DIAGNOSTICS offers new early prognostic marker for RA

Activity and outcome scores like DAS, DAS28, SDAI or CDAI, Larsen Score, etc. are commonly used but are time consuming and not practical in the early phase of rheumatoid arthritis (RA).

17 Jul 2015

Scientists discover protein that plays significant role in development of fragile X syndrome

Scientists at VIB and KU Leuven have discovered that the protein APP plays a significant role in the development of fragile X syndrome (FXS) at young stages. They identified an unexpected biological pathway as a promising target to ameliorate deficits associated with FXS and autism. The results have recently been published in Neuron, one of the most influential journals in the field of neuroscience.

16 Jul 2015

New drug DSM265 shows potential to cure, prevent malaria

Researchers at UT Southwestern Medical Center and in Australia have shown that a drug currently in testing shows potential to cure malaria in a single dose and offers promise as a preventive treatment as well.

16 Jul 2015

Study stresses importance of investigating telomeres to improve diagnoses, develop treatments for many diseases

Studying telomeres, the structures that protect the ends of chromosomes, has become a key issue in biology. In recent years, not only has their relation to ageing been confirmed; defective telomeres seem to be linked to more and more illnesses, including many types of cancer.

16 Jul 2015

Single molecule appears to be central regulator driving cancer metastasis

Cancer is a disease of cell growth, but most tumors only become lethal once they metastasize or spread from their first location to sites throughout the body. For the first time, researchers at Thomas Jefferson University in Philadelphia report a single molecule that appears to be the central regulator driving metastasis in prostate cancer.

14 Jul 2015

New UW-Madison study links two unrelated cancer treatments

A new study at the University of Wisconsin-Madison has linked two seemingly unrelated cancer treatments that are both now being tested in clinical trials.

14 Jul 2015

Chromosomes play active role in animal cell division

Canadian and British researchers have discovered that chromosomes play an active role in animal cell division. This occurs at a precise stage - cytokinesis - when the cell splits into two new daughter cells.

14 Jul 2015

Study offers new way to suppress growth factors related to cancer cell proliferation

Cancer cells need life-essential molecules to proliferate. These so-called growth factors are activated by ectodomain shedding of precursor proteins on the outside of the plasma membrane, mainly carried out by three human cleavage enzymes. A pharmaceutical blocking of these enzymes could hinder cancer from growing but would also inhibit other life-essential processes.

13 Jul 2015

Recently-developed drug holds great promise for children with acute lymphoblastic leukaemia

A new Australian study shows that a recently-developed drug, already used safely in adult leukaemia clinical trials, holds great promise for some children with an aggressive form of cancer known as acute lymphoblastic leukaemia (ALL).

10 Jul 2015

FDA approves new heart failure drug

A new drug called Entresto has been approved by the U.S Food and Drug Administration (FDA) for the treatment of heart failure.

9 Jul 2015

Risk of hepatobiliary cancer, cardiovascular diseases later in life is higher in women with ICP

In a new study of more than 125,000 pregnant women in Sweden, researchers found that the risk of hepatobiliary cancer and immune-mediated and cardiovascular diseases later in life is higher in women with intrahepatic cholestasis of pregnancy (ICP) than in women without this condition.

9 Jul 2015

Defects in mitochondria play key role in transition of normal cells to cancerous cells

Cancer cells defy the rules by which normal cells abide. They can divide without cease, invade distant tissues and consume glucose at abnormal rates.

9 Jul 2015

International research team identifies new gene associated with 4H leukodystrophy

Leukodystrophies are deadly neurodegenerative diseases that affect one in 7,000 children and remain incurable. These genetic diseases attack myelin or the "insulating rubber sheath" surrounding neurons, which leads to deteriorating health for affected children.

9 Jul 2015

SISSA scientists create synthetic enzymes that can differentiate between active and inactive genes

Certain genetic diseases arise from a deficit of specific genes. An enzyme that amplifies gene transcription could be a viable therapy in these cases, as long as genes are not stimulated to work on the wrong part of the body. SISSA scientists have created synthetic "intelligent" enzymes which are able to differentiate between active and inactive genes and selectively stimulate the former ones.

8 Jul 2015

Enzyme News and Research

Researchers develop dynamic smart drug that targets site-specific inflammation

Study reveals potential new therapeutic target for depression treatment

MetLife Foundation Awards for Medical Research presented at AAIC 2015

Researchers find evidence that directly links disrupted metabolism to fatal type of lymphoma

Scientists find potent agent that thwarts drug resistance in malaria parasite

UT Southwestern researchers find potential therapy to treat diabetes, nonalcoholic fatty liver disease

AESKU.DIAGNOSTICS offers new early prognostic marker for RA

Scientists discover protein that plays significant role in development of fragile X syndrome

New drug DSM265 shows potential to cure, prevent malaria

Study stresses importance of investigating telomeres to improve diagnoses, develop treatments for many diseases

Single molecule appears to be central regulator driving cancer metastasis

New UW-Madison study links two unrelated cancer treatments

Chromosomes play active role in animal cell division

Study offers new way to suppress growth factors related to cancer cell proliferation

Recently-developed drug holds great promise for children with acute lymphoblastic leukaemia

FDA approves new heart failure drug

Risk of hepatobiliary cancer, cardiovascular diseases later in life is higher in women with ICP

Defects in mitochondria play key role in transition of normal cells to cancerous cells

International research team identifies new gene associated with 4H leukodystrophy

SISSA scientists create synthetic enzymes that can differentiate between active and inactive genes

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