Genetic News and Research

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Three genetic mutations seen in individuals with KCNMA1-linked channelopathy successfully mirrored in mice

Three genetic alterations associated with a rare seizure and a movement disorder primarily found in children were successfully mirrored in mice and their symptoms treated, in a new study from a University of Maryland School of Medicine researcher, Andrea Meredith, PhD, Professor of Physiology and her collaborators.

15 Aug 2022

Men exposed to industrial air pollution exhibit sperm mitochondrial DNA deletions

Researchers compare the length spectra of sperm mitochondrial DNA deletions in two seasons with varied air pollution levels.

14 Aug 2022

How does birth weight affect long-term risk of mortality among men and women?

Researchers evaluate the relationship between birth weight and cause-specific mortality.

14 Aug 2022

Scientists create a mathematical model to predict genetic resistance to antimalarial drugs

Researchers have created a mathematical model to predict genetic resistance to antimalarial drugs in Africa to manage one of the biggest threats to global malarial control.

12 Aug 2022

Older heart muscle cells accumulate new genetic mutations -; while losing the ability to repair them

Why does the risk of heart disease go up as we age? Known risk factors such as hypertension or high cholesterol don't explain all cases.

12 Aug 2022

Mount Sinai and Regeneron Genetics Center launch a new human genome sequencing research project

Mount Sinai Health System and the Icahn School of Medicine at Mount Sinai have launched a new human genome sequencing research project called the Mount Sinai Million Health Discoveries Program with the Regeneron Genetics Center (RGC), part of the industry-leading, New York-based biotechnology company Regeneron.

12 Aug 2022

Doctors discover genetic and viral causes of adenoid hypertrophy in kids

RUDN doctors have discovered genetic and viral causes of a frequent ENT disease in children - adenoid hypertrophy. The results are published in Life.

11 Aug 2022

Study highlights the urgent need for combinatorial drug therapies for SARS-CoV-2

Researchers investigated the susceptibility of naturally-occurring severe acute respiratory syndrome coronavirus 2 main protease variants to protease inhibitor drugs, including nirmatrelvir and ensitrelvir.

11 Aug 2022

Recombination most often occurs on the COVID-19 phylogenetic tree in the form of 'long branches'

An analysis of millions of SARS-CoV-2 genomes finds that recombination of the virus is uncommon, but when it occurs, it is most often in the spike protein region, the area which allows the virus to attach to and infect host cells.

11 Aug 2022

OICR funding to help five research projects take the next step toward advancing cancer care

Five Ontario-based research projects will take the next step toward advancing cancer care in the province thanks to funding from the Ontario Institute for Cancer Research (OICR).

11 Aug 2022

UCL researchers identify strategies for minimizing weight bias among healthcare professionals

To help tackle the UK's obesity crisis, we must better educate medical professionals on weight stigma, according to the conclusions of a large-scale review led by UCL researchers.

11 Aug 2022

Novel model reveals how genomic instability arises in histologically benign tissue

Understanding which cells give rise to which areas of cancer can improve our understanding of how a tumor has grown and developed, including how it has changed genetically, over time. This has been made possible using a new technique called spatial transcriptomics, which allows scientists to see what genetic changes take place without breaking up the tissue they're looking at.

11 Aug 2022

Nearly three-quarters of all stem cell lines are affected by DNA damage, say researchers

DNA damage caused by factors such as ultraviolet radiation affect nearly three-quarters of all stem cell lines derived from human skin cells, say Cambridge researchers, who argue that whole genome sequencing is essential for confirming if cell lines are usable.

11 Aug 2022

Study defines how the circadian clock influences cell growth, metabolism and tumor progression

In a new University of California, Irvine-led study, researchers define how the circadian clock influences cell growth, metabolism and tumor progression.

11 Aug 2022

Gene expression in male and female brains become more similar with age, study says

When male and female fruit flies age, their brains become desexualized. Age-related changes take place in both sexes, but the male brain becomes feminized to a larger extent than the female brain becomes masculinized. This is the conclusion of a study performed by a research group at Linköping University. The findings are published in the journal Proceedings of the Royal Society of London B.

11 Aug 2022

Collagen XII likely to be a potential marker for patients at high risk of metastatic relapse

Collagen type XII plays a key role in regulating the organization of the tumor matrix, reveals a new study from the Garvan Institute of Medical Research. A team of scientists led by Associate Professor Thomas Cox, Head of the Matrix and Metastasis lab, also discovered that high levels of collagen XII can trigger breast cancer cells to spread from the tumor to other parts of the body, a process known as metastasis.

11 Aug 2022

New computation-guided approach to identify small molecule corrector drugs for p53 hotspot mutations

A new study, led by researchers from the University of California, Irvine and the University of California, San Diego, reveals a new computation-guided approach to identify small molecules that can restore aspects of wild-type p53 tumor suppression function to mutated p53, which play an important role in many human cancers.

11 Aug 2022

Scientists discover new target for treatment of premature aging disorders

A stretch of DNA that hops around the human genome plays a role in premature aging disorders, scientists at the Salk Institute and King Abdullah University of Science and Technology in Saudi Arabia have discovered.

10 Aug 2022

UTSW scientists discover mechanism of RNA capping by SARS-CoV-2 virus

A team led by UT Southwestern researchers has identified how SARS-CoV-2, the virus that causes COVID-19, builds a structure called the RNA cap that's critical for successful viral replication.

10 Aug 2022

Monoclonal antibody decreases asthma attacks by 27% in children and adolescents of color

A monoclonal antibody, mepolizumab, decreased asthma attacks by 27% in Black and Hispanic children and adolescents who have a form of severe asthma, are prone to asthma attacks and live in low-income urban neighborhoods, a National Institutes of Health clinical trial has found.

10 Aug 2022

Genetic News and Research

Three genetic mutations seen in individuals with KCNMA1-linked channelopathy successfully mirrored in mice

Men exposed to industrial air pollution exhibit sperm mitochondrial DNA deletions

How does birth weight affect long-term risk of mortality among men and women?

Scientists create a mathematical model to predict genetic resistance to antimalarial drugs

Older heart muscle cells accumulate new genetic mutations -; while losing the ability to repair them

Mount Sinai and Regeneron Genetics Center launch a new human genome sequencing research project

Doctors discover genetic and viral causes of adenoid hypertrophy in kids

Study highlights the urgent need for combinatorial drug therapies for SARS-CoV-2

Recombination most often occurs on the COVID-19 phylogenetic tree in the form of 'long branches'

OICR funding to help five research projects take the next step toward advancing cancer care

UCL researchers identify strategies for minimizing weight bias among healthcare professionals

Novel model reveals how genomic instability arises in histologically benign tissue

Nearly three-quarters of all stem cell lines are affected by DNA damage, say researchers

Study defines how the circadian clock influences cell growth, metabolism and tumor progression

Gene expression in male and female brains become more similar with age, study says

Collagen XII likely to be a potential marker for patients at high risk of metastatic relapse

New computation-guided approach to identify small molecule corrector drugs for p53 hotspot mutations

Scientists discover new target for treatment of premature aging disorders

UTSW scientists discover mechanism of RNA capping by SARS-CoV-2 virus

Monoclonal antibody decreases asthma attacks by 27% in children and adolescents of color

Genetics & Genomics - Second Edition eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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