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New stem-cell model of heart tissue unravels mechanisms linked to hypertrophic cardiomyopathy

Using advanced stem cell technology, scientists from the Icahn School of Medicine at Mount Sinai have created a model of a heart condition called hypertrophic cardiomyopathy (HCM) — an excessive thickening of the heart that is associated with a number of rare and common illnesses, some of which have a strong genetic component.

31 Aug 2016

Study reveals vital new details about inner workings of CRISPR-Cas9 machinery in live cells

A study in The Journal of Cell Biology by scientists at the University of Massachusetts Medical School reveals important new details about the inner workings of the CRISPR-Cas9 machinery in live cells that may have implications for the development of therapeutics that use the powerful gene editing tool.

30 Aug 2016

UT Southwestern researchers identify protein that can kick-start more efficient, healthful breakdown of fat

Researchers at UT Southwestern Medical Center have found that a protein often located on the surface of fat droplets within cells - and especially abundant in the muscles of endurance athletes - can kick-start the more efficient and healthful breakdown of fat.

27 Aug 2016

New biomaterial allows scientists to study how stem cells sense stiffness of surrounding environment

A new biomaterial can be used to study how and when stem cells sense the mechanics of their surrounding environment, found a team led by Robert Mauck, PhD, the Mary Black Ralston Professor for Education and Research in Orthopaedic Surgery, in the Perelman School of Medicine at the University of Pennsylvania.

26 Aug 2016

UNC researchers map anxiety circuit in the brain that may explain side effects of antidepressants

More than 100 million people worldwide take selective serotonin reuptake inhibitors (SSRIs), such as Prozac and Zoloft, to treat depression, anxiety and related conditions, but these drugs have a common and mysterious side effect: they can worsen anxiety in the first few weeks of use, which leads many patients to stop treatment.

25 Aug 2016

UT Southwestern researchers discover protein that can promote healthful breakdown of fat

25 Aug 2016

Research offers new insights into sleep/awake patterns in animals

Research from University of California, Irvine scientists and their colleagues offers new insights into why many animals sleep at night and are active during the day, while others do the reverse.

23 Aug 2016

Nobel laureate-led study uses new technology to watch interaction between telomerase and telomeres

As the rope of a chromosomes replicates, it frays at the ends. No problem: A chromosome's ends have extra twine so that fraying doesn't reach into the body of the rope where the important information resides.

19 Aug 2016

TSRI scientists find evidence supporting new therapeutic strategy against cocaine addiction

An international team led by scientists at The Scripps Research Institute has found strong evidence supporting a new strategy against drug addiction.

18 Aug 2016

IRB Barcelona scientists rediscover utility of disordered proteins as therapeutic targets

Prostate cancer, Alzheimer's, Parkinson's...these three diseases are associated with proteins that share a common feature, namely disordered regions that have no apparent rigid three-dimensional structure.

16 Aug 2016

New study uncovers how chromosomal changes impact tumor formation and growth

As with most cancers, triple-negative breast cancer (TNBC) cells have abnormal amounts of chromosomes or DNA copy number aberrations (CNAs) in their genomes.

16 Aug 2016

New disease gene linked to shortened telomeres appears to raise risk of pulmonary fibrosis-emphysema

Johns Hopkins researchers say they have identified a new disease gene that, when mutated, appears to increase the risk in a small number of people of developing emphysema and a lung-scarring condition known as pulmonary fibrosis.

10 Aug 2016

Novel compound holds potential for next-generation prostate cancer treatment

In the search for new ways to attack recurrent prostate cancer, researchers at Duke Health report that a novel compound appears to have a unique way of blocking testosterone from fueling the tumors in mice.

8 Aug 2016

New study shows how the body’s biological clock suppresses inflammation during night-time sleep

New research published online in The FASEB Journal, describes a protein created by the body's "biological clock" that actively represses inflammatory pathways within the affected limbs during the night.

8 Aug 2016

New findings on microcephaly may offer clues to explore how Zika virus disrupts brain development

Long before Zika virus made it a household word, the birth defect called microcephaly puzzled scientists and doctors -- even as it changed the lives of the babies born with it during the pre-Zika era.

8 Aug 2016

Study reveals alterations in silent synapses could trigger drug-related memories in addiction

In addiction, cues in the environment can form strong associations with the drug of abuse. A new study in Biological Psychiatry suggests that alterations in silent synapses, inactive connections between neurons, could be the neural mechanism underlying the formation of these drug-related memories.

3 Aug 2016

Biologists discover male-harming mtDNA mutant that substantiates mother's curse hypothesis

There is new evidence that the "mother's curse" - the possibility that moms may transmit genes to their children that harm their sons but not their daughters - holds true in animals.

3 Aug 2016

Scientists uncover novel sites of expression in the brain for gene linked to ALS and FTD

For the first time novel expression sites in the brain have been identified for a gene which is associated with Motor Neuron Disease and Frontotemporal Dementia.

1 Aug 2016

Researchers discover genetic changes in MSH3 gene in patients with hereditary colon cancer

The formation of large numbers of polyps in the colon has a high probability of developing into colon cancer, if left untreated.

28 Jul 2016

Penn study sheds new light on biology of fatty liver disease

A new appreciation for the interplay between two cell nucleus proteins that lead both intertwined and separate lives is helping researchers better understand fatty liver disease, according to a new study by researchers at the Perelman School of Medicine at the University of Pennsylvania.

27 Jul 2016

Cell Nucleus News and Research

New stem-cell model of heart tissue unravels mechanisms linked to hypertrophic cardiomyopathy

Study reveals vital new details about inner workings of CRISPR-Cas9 machinery in live cells

UT Southwestern researchers identify protein that can kick-start more efficient, healthful breakdown of fat

New biomaterial allows scientists to study how stem cells sense stiffness of surrounding environment

UNC researchers map anxiety circuit in the brain that may explain side effects of antidepressants

UT Southwestern researchers discover protein that can promote healthful breakdown of fat

Research offers new insights into sleep/awake patterns in animals

Nobel laureate-led study uses new technology to watch interaction between telomerase and telomeres

TSRI scientists find evidence supporting new therapeutic strategy against cocaine addiction

IRB Barcelona scientists rediscover utility of disordered proteins as therapeutic targets

New study uncovers how chromosomal changes impact tumor formation and growth

New disease gene linked to shortened telomeres appears to raise risk of pulmonary fibrosis-emphysema

Novel compound holds potential for next-generation prostate cancer treatment

New study shows how the body’s biological clock suppresses inflammation during night-time sleep

New findings on microcephaly may offer clues to explore how Zika virus disrupts brain development

Study reveals alterations in silent synapses could trigger drug-related memories in addiction

Biologists discover male-harming mtDNA mutant that substantiates mother's curse hypothesis

Scientists uncover novel sites of expression in the brain for gene linked to ALS and FTD

Researchers discover genetic changes in MSH3 gene in patients with hereditary colon cancer

Penn study sheds new light on biology of fatty liver disease

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