Cell Proliferation News and Research

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Study describes unconventional mechanism of ionic channel traffic in cardiac cells

Ionic channels -integral proteins in the cell membrane- are essential in several processes such as cardiac activity, nervous transmission, cell proliferation and the regulation of blood pressure.

18 Apr 2020

Potential cure for heart disease via cancer gene upregulation

Researchers have found that by switching on a gene that promotes the spread of cancers, they can enhance the regeneration of damaged heart muscle. The study results, published in April 2020 in the journal Nature Communication, could mark the beginning of curative therapy for heart disease.

14 Apr 2020

Researchers find direct link between MCL1 protein and cell-cycle checkpoint protein

Human cells respond to stresses like DNA damage, metabolic imbalance and starvation by first trying to repair the problem.

5 Apr 2020

New study overturns ‘snapshot’ model of cell cycle accepted since 1974

Cells have a big decision: Should they replicate or sleep? Healthy cells can go either way. Cancer cells' replication switches are stuck in the 'on' position.

2 Apr 2020

YAP signal pathway plays a vital role in the onset of head-and-neck cancer

Joint research between Kobe University and National Hospital Organization Kyushu Cancer Center has revealed that mice with mutations in the YAP signal pathway develop head-and-neck cancer over an extremely short period of time (world's fastest cancer onset mouse model), indicating that this pathway plays a crucial role in the onset of these cancers.

25 Mar 2020

Targeting PI3Kβ alone and with combination therapy in PTEN-deficient tumors

The cover for issue 11 of Oncotarget features Figure 6, "Effects of AZD8186 in combination with anti-PD1 on syngeneic models," by Owusu-Brackett, et al.

18 Mar 2020

Researchers explore the role of SLC25A32 in cancer cell proliferation

Oncotarget Volume 11 Issue 8 reported that while it is known that cancer cells require one-carbon and FAD-dependent mitochondrial metabolism to sustain cell proliferation, the role of SLC25A32 in cancer cell growth remains unexplored.

28 Feb 2020

New discovery may be useful for developing novel cancer treatments

Researchers from the University of Copenhagen have discovered that our cells replicate their DNA much more loosely than previously thought.

28 Feb 2020

Study analyzes the effect of maternal smoking on newborns’ body size and proportion

Although quitting smoking during the 1st trimester of pregnancy reduces the risk of low birth weight, it isn't enough to protect the unborn child from being born shorter and with smaller brain size, a new study from the University of Eastern Finland shows.

26 Feb 2020

New study expands the knowledge on tumor-suppressor role of HERC proteins

The RAF protein could be a therapeutical target to treat the tumor growth in regulated pathways by the p38 protein, according to a new study published in the journal Scientific Reports by a team of experts of the Faculty of Medicine and Health Sciences of the University of Barcelona and the Bellvitge Institute for Biomedical Research.

20 Feb 2020

Single gene cluster loss promotes initiation and progression of multiple myeloma in mice

The loss of one copy of the miR15a/miR16-1 gene cluster promoted initiation and progression of multiple myeloma in mice.

20 Feb 2020

Combination therapy for pediatric low-grade gliomas shows promise in mice

In experiments with human cells and mice, researchers at the Johns Hopkins Kimmel Cancer Center report evidence that combining the experimental cancer medication TAK228 (also called sapanisertib) with an existing anti-cancer drug called trametinib may be more effective than either drug alone in decreasing the growth of pediatric low-grade gliomas.

17 Feb 2020

P53-deficient oral cancers recruit and reprogram nerves to fuel tumor growth

Loss of an important tumor-suppressing gene allows head and neck cancer to spin off signals to nearby nerves, changing their function and recruiting them to the tumor, where they fuel growth and cancer progression, researchers from The University of Texas MD Anderson Cancer Center report in the journal Nature today.

13 Feb 2020

Novel drug combination discovered to induce high rates of human beta cell proliferation

Researchers at the Icahn School of Medicine at Mount Sinai have discovered a novel combination of two classes of drugs that, together, cause the highest rate of proliferation ever observed in adult human beta cells- the cells in the pancreas that produce insulin- without harming most other cells in the body.

12 Feb 2020

Discovery identifies an adaptation by cancer cells that promotes metastasis

The discovery identifies an adaptation by cancer cells that facilitates their spreading to distant sites, and the potential for targeting these features to prevent or slow the progression of metastatic hormone receptor-positive breast cancer.

12 Feb 2020

Study explores how some mammals postpone development of their embryos

How do some mammals postpone the development of their embryos to await better conditions for having offspring? A recent study at the UW Medicine Institute for Stem Cell and Regenerative Medicine explored this reproductive enigma, which can occur in more than 130 species of mammals as well as in some marsupials.

10 Feb 2020

Targeting the microenvironment of cancer cells to inhibit tumor growth

The recognition of bacterial infections or foreign substances is mediated and controlled by the human immune system. This innate and adaptive immune system comprises the most important metabolic and cellulare processes to fight against infections and other diseases.

5 Feb 2020

New step toward understanding cancer prevention in evolutionary terms

A new Scientific Reports paper puts an evolutionary twist on a classic question. Instead of asking why we get cancer, Leonardo Oña of Osnabrück University and Michael Lachmann of the Santa Fe Institute use signaling theory to explore how our bodies have evolved to keep us from getting more cancer.

4 Feb 2020

Research reveals key molecular target for colorectal cancer therapy

Serine racemase is a multifunctional enzyme that carries out several different reactions in human cells, including the conversion of L-serine into pyruvate.

29 Jan 2020

Scientists discover why the cells need acidic lysosomes

Just like the body contains lungs, liver, and lymph nodes, so does each of the body's cells contain tiny specialized organs. Perhaps most peculiar among them are lysosomes--bubble-like sacks that act as part recycling bin, part stomach.

23 Jan 2020