Chromosome 2 News and Research

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Chromosome 2 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 2 is the second largest human chromosome, spanning more than 237 million base pairs (the building material of DNA) and representing almost 8% of the total DNA in cells.

Princeton researchers uncover vital role played by a protein elevated in many cancers

Researchers at Princeton University have successfully recreated a key process involved in cell division in a test tube, uncovering the vital role played by a protein that is elevated in over 25% of all cancers.

14 Jan 2020

Study sheds new light on impact of common plasticizer on human reproductive health

Researchers at Harvard Medical School and the New York State Department of Health have discovered how a common plasticizer associated with human reproductive abnormalities likely does its damage at the molecular level.

10 Jan 2020

Common genetic defect in prostate cancer associated with worse prognosis

Like security screening to make sure nothing harmful makes its way into a crowded area, cells in the human body use checkpoints to control their growth and prevent harmful mutations from making their way into new cell populations and causing trouble.

9 Jan 2020

Dog study suggests that AAV in gene therapy could induce cancer

A gene therapy study in dogs has stirred up old fears that by using AAV in gene therapy, it may be increasing cancer chances.

8 Jan 2020

Drug trial seeking treatment option for hyperphagia in patients with Prader-Willi Syndrome

One in every 15,000 children is affected by Prader-Willi syndrome (PWS), a complex, genetic endocrine condition caused by a disorder of chromosome 15. It's non-inheritable, meaning the condition isn't passed down from a family member.

3 Jan 2020

Inserting end-modified DNA fragments with CRISPR-Cas9 yields highest efficiency

University of Illinois researchers achieved the highest reported rates of inserting genes into human cells with the CRISPR-Cas9 gene-editing system, a necessary step for harnessing CRISPR for clinical gene-therapy applications.

23 Dec 2019

New, faster and cheaper method to uncover genetic variants in single cells

Researchers led by the European Molecular Biology Laboratory in Heidelberg and the Center for Bioinformatics at Saarland University in Saarbrücken, Germany, have developed a cheaper and faster method to check for genetic differences in individual cells, which outperforms existing techniques with respect to the information received.

23 Dec 2019

Researchers develop powerful computer algorithm for large-scale genomic analysis

Haplotypes are a set of genetic variations that, located side by side on the same chromosome, are transmitted in a single group to the next generation. Their examination makes it possible to understand the heritability of certain complex traits, such as the risk of developing a disease.

20 Dec 2019

Extrachromosomal circular DNA can contribute to cancer development in children

Cancer development is associated with the gradual accumulation of DNA defects over time. Thus, cancer is considered an age-related disease.

17 Dec 2019

Tackling antibiotic resistance head-on with CRISPR

With modern advances in genetic engineering occurring almost every day, the latest discovery concerns antibiotic resistance. Using the powerful gene editor CRISPR, scientists reported the development of a gene-drive system that is 100 times as efficient as other current systems at inactivating a specific bacterial gene responsible for making the bacterium antibiotic-resistant and which is present as multiple copies within the same bacterial cell.

16 Dec 2019

Precision epigenome editing can repair genetic syndrome of intellectual disability

Using a targeted gene epigenome editing approach in the developing mouse brain, Johns Hopkins Medicine researchers reversed one gene mutation that leads to the genetic disorder WAGR syndrome, which causes intellectual disability and obesity in people.

13 Dec 2019

UCLA scientists discover reason for higher rates of autoimmune disease in women than men

UCLA scientists have discovered one reason why autoimmune diseases are more prevalent in women than in men.

11 Dec 2019

Epigenome editing could repair genetic brain disorder

A new study published in the journal Nature Communications shows that it may be possible to reverse gene mutations that cause brain disorders, using a very precisely targeted epigenome editing technique. This type of gene editing does not change the gene’s DNA sequence itself but is focused on correcting epigenome changes only. The condition that was corrected in the study is called the WAGR syndrome and is associated with obesity and intellectual disability in people.

11 Dec 2019

Genetic alteration increases risk of Autism and Tourette's impacts on the brain

Lancaster University researchers have discovered, for the first time, how a genetic alteration that increases the risk of developing Autism and Tourette's impacts on the brain.

10 Dec 2019

Combination therapy is safe and effective for older patients diagnosed with acute lymphoblastic leukemia

A study led by The University of Texas MD Anderson Cancer Center showed that treatment combining lower doses of chemotherapy with the monoclonal antibody inotuzumab ozogamicin (INO), with or without the drug blinatumomab, is safe and effective in patients over 60 years of age who were newly diagnosed with a high-risk form of acute lymphoblastic leukemia (ALL) known as Philadelphia chromosome-negative ALL.

10 Dec 2019

Kanazawa University researchers describe genetic typing of Pseudomonas putida

Pseudomonas putida is a bacterium occuring in soil, aquatic environments and plants. Although the virulence of Pseudomonas p. -- the ability of the bacterium to infect its host and inflict a disease -- is considered to be low, infection in severely ill patients can be lethal. P. putida strains (also called isolates) have been found in hospitals, e.g. in urine, blood or wound discharge from patients, and such clinical isolates have been found to display resistance to drugs.

6 Dec 2019

Chromosome 2 News and Research

Further Reading

Princeton researchers uncover vital role played by a protein elevated in many cancers

Study sheds new light on impact of common plasticizer on human reproductive health

Common genetic defect in prostate cancer associated with worse prognosis

Dog study suggests that AAV in gene therapy could induce cancer

Drug trial seeking treatment option for hyperphagia in patients with Prader-Willi Syndrome

Inserting end-modified DNA fragments with CRISPR-Cas9 yields highest efficiency

New, faster and cheaper method to uncover genetic variants in single cells

Researchers develop powerful computer algorithm for large-scale genomic analysis

Extrachromosomal circular DNA can contribute to cancer development in children

Tackling antibiotic resistance head-on with CRISPR

Precision epigenome editing can repair genetic syndrome of intellectual disability

UCLA scientists discover reason for higher rates of autoimmune disease in women than men

Epigenome editing could repair genetic brain disorder

Genetic alteration increases risk of Autism and Tourette's impacts on the brain

Combination therapy is safe and effective for older patients diagnosed with acute lymphoblastic leukemia

Kanazawa University researchers describe genetic typing of Pseudomonas putida

New discovery on chromosomal function may shed light on human health and disease

Tulane neuroscientist receives $2.9 million NIH grant to launch the Telomere Research Network

New vaccine against bovine TB

Extra DNA scooped up alongside cancer-causing genes helps drive tumor growth

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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