Malignant News and Research

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Novel drug target may help overcome resistance to EZH2 inhibitors in SMARCB1 mutated cancers

Inhibitors of the protein EZH2 are effective against cancers with SMARCB1 mutations such as rhabdoid tumors in children.

9 May 2022

T cell behavior informs metastatic melanoma outcomes

Immunotherapy unleashes the power of the immune system to fight cancer. However, for some patients, immunotherapy doesn't work, and new research may help explain why.

9 May 2022

What can chimpanzees tell us about cancer propensity in humans?

A recent study published in the renowned journal Cell Reports finds evidence for reduced functional activity of certain human cancer genes (such as breast cancer 2 gene or BRCA2), following the divergence from the chimpanzee-human last common ancestor.

9 May 2022

The Josep Carreras Leukaemia Research Institute joins Cancer Proteome Project

The Josep Carreras Institute becomes part of the Cancer Proteome project, an international initiative for the study of malignant tumors.

6 May 2022

Antigen-presenting cancer-associated fibroblasts offer a new target to fight pancreatic cancer

Scar-like cells that make up a sizable portion of malignant pancreatic tumors and shield these cancers from immune attack are derived from mesothelial cells that line tissues and organs, a new study led by UT Southwestern researchers suggests.

6 May 2022

New technique can accurately detect viruses in tumors from clinical next-generation sequencing

Researchers have developed a method to accurately detect viruses from clinical next-generation sequencing and describe novel associations between specific tumors and viruses that warrant further investigation.

5 May 2022

Low-cost handheld device could cut the rate of unnecessary skin biopsies

Skin biopsies are no fun: doctors carve away small lumps of tissue for laboratory testing, leaving patients with painful wounds that can take weeks to heal.

5 May 2022

Evaluating a third SARS-CoV-2 mRNA vaccine in anti-CD20-treated patients

In a new study, researchers assessed the efficacy of a third dose of COVID-19 vaccine in anti-CD20 antibody-treated individuals.

4 May 2022

Multifunctional YHM shows promise for diagnosis and treatment of orthotopic glioma

Glioma is an intracranial malignant tumor that still poses a major clinical challenge due to its highly invasive nature, low cure rate, and high mortality rate.

3 May 2022

Researchers discover molecular mechanisms underlying extreme need for amino acids in neuroblastoma

Certain childhood tumors have an extreme need for amino acids. Scientists at the Hopp Children's Cancer Center Heidelberg (KiTZ), the German Cancer Research Center (DKFZ), the University of Heidelberg, and HI-STEM gGmbH have now discovered the molecular mechanisms underlying this and how the cancer cells could be turned off.

28 Apr 2022

Novel method could bring life-saving benefits of CAR T-cell therapy to patients with acute myeloid leukemia

Massachusetts General Hospital researchers have developed a novel treatment strategy that has the potential to bring the life-saving benefits of chimeric antigen receptor T-cell therapy (CAR T) to patients with acute myeloid leukemia (AML) the most common form of leukemia in adults.

28 Apr 2022

Exploring oncolytic viral therapeutics and immunotherapies derived from DNA and RNA

A new review initially described the developments in cancer-based medicines that included vaccinations, vector-based techniques, and genome injection using DNA and RNA-based nucleic acid therapeutics.

28 Apr 2022

Blood test could aid in the differential diagnosis of preeclampsia and COVID-19 in pregnant women

Pregnancy brings deep changes in women's physiology, especially regarding her blood system. The placenta is the organ which ensures an efficient communication between the mother and the baby.

27 Apr 2022

Researchers reveal how not-yet-malignant cells “turn on” and become metastatic breast cancer

Mount Sinai researchers have discovered a previously unknown mechanism in which not-yet-malignant cells from early breast cancer tumors travel to other organs and, eventually, "turn on" and become metastatic breast cancer.

26 Apr 2022

Single-cell atlas of non-hematopoietic cells provides insights into lymphoma stromal biology

Researchers from the University of Tsukuba identify gene expression signatures in different types of lymph nodes cells that play an active role in the development of lymphomas.

21 Apr 2022

DNA abnormality explains insensitivity to chemotherapy in germ cell cancer

Extra copies of a piece of DNA partly explain insensitivity to chemotherapy in germ cell cancer, a new study shows.

20 Apr 2022

Researchers discover a novel signaling pathway that defines interferon responses in blood cancers

Northwestern Medicine investigators have discovered a novel signaling pathway activated by interferons, a group of immune system proteins, that suppresses the anti-tumor response of interferons in patients with a particular type of blood cancer, according to findings published in Nature Communications.

19 Apr 2022

Malignant News and Research

Novel drug target may help overcome resistance to EZH2 inhibitors in SMARCB1 mutated cancers

T cell behavior informs metastatic melanoma outcomes

What can chimpanzees tell us about cancer propensity in humans?

The Josep Carreras Leukaemia Research Institute joins Cancer Proteome Project

Antigen-presenting cancer-associated fibroblasts offer a new target to fight pancreatic cancer

New technique can accurately detect viruses in tumors from clinical next-generation sequencing

Low-cost handheld device could cut the rate of unnecessary skin biopsies

Evaluating a third SARS-CoV-2 mRNA vaccine in anti-CD20-treated patients

Multifunctional YHM shows promise for diagnosis and treatment of orthotopic glioma

Researchers discover molecular mechanisms underlying extreme need for amino acids in neuroblastoma

Novel method could bring life-saving benefits of CAR T-cell therapy to patients with acute myeloid leukemia

Exploring oncolytic viral therapeutics and immunotherapies derived from DNA and RNA

Blood test could aid in the differential diagnosis of preeclampsia and COVID-19 in pregnant women

Researchers reveal how not-yet-malignant cells “turn on” and become metastatic breast cancer

Single-cell atlas of non-hematopoietic cells provides insights into lymphoma stromal biology

DNA abnormality explains insensitivity to chemotherapy in germ cell cancer

Researchers discover a novel signaling pathway that defines interferon responses in blood cancers

New nanotechnology approach developed for the elimination of endometriosis lesions

New data-driven mechanistic approach can help reduce drug costs and treat diseases

Recent advances in non-viral nano-vector delivery of CRISPR/Cas9 genome editing payloads

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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