Metastasis News and Research

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Metastasis is the spread of cancer from one part of the body to another. A tumor formed by cells that have spread is called a “metastatic tumor” or a “metastasis.” The metastatic tumor contains cells that are like those in the original (primary) tumor. The plural form of metastasis is metastases

Study uncovers new regulator of prostate cancer metastasis

A transcription factor normally associated with androgen receptor activity in prostate cancer has a newly discovered role in controlling lipid biosynthesis, according to a Northwestern Medicine study published in Nature Genetics.

10 May 2022

New guideline provides guidance on the use of radiation therapy to treat patients with brain metastases

A new clinical guideline from the American Society for Radiation Oncology provides guidance on the use of radiation therapy to treat patients with brain metastases.

10 May 2022

Scientists identify the role of phospholipid in maintaining epithelial cellular adhesion

Cells have certain proteins that help them adhere to each other while covering body surfaces and organs. Loss of these identifying proteins could result in cellular progression towards cancer and, subsequently, metastasis.

9 May 2022

How new Insights into ESR1 Mutant Breast Cancers may lead to Novel Therapy Targets

In this interview, we speak to Steffi Oesterreich, PH.D., from the University of Pittsburgh, about how new insights into a gene mutation present in 20-30% of breast cancer recurrences may have a silver lining, leading to novel treatment opportunities.

9 May 2022

$Using AI to predict how cancer may affect the probability of spinal fractures$

Using AI to predict how cancer may affect the probability of spinal fractures

As medicine continues to embrace machine learning, a new study suggests how scientists may use artificial intelligence to predict how cancer may affect the probability of fractures along the spinal column.

5 May 2022

Novel plug-and-play multi-organ chip can be customized to the patient

Engineered tissues have become a critical component for modeling diseases and testing the efficacy and safety of drugs in a human context.

27 Apr 2022

Combination therapy shows promise for treating triple-negative breast cancer

Researchers at Baylor College of Medicine and collaborating institutions have identified a combination therapy for treating triple-negative breast cancer (TNBC) that results in durable tumor regression in an animal model of the condition.

27 Apr 2022

Researchers reveal how not-yet-malignant cells “turn on” and become metastatic breast cancer

Mount Sinai researchers have discovered a previously unknown mechanism in which not-yet-malignant cells from early breast cancer tumors travel to other organs and, eventually, "turn on" and become metastatic breast cancer.

26 Apr 2022

Reprogrammed macrophages promote the settlement of breast cancer metastases in the lungs

Metastatic breast cancer cells abuse macrophages, a type of immune cell, to promote the settlement of cancer metastases in the lungs.

25 Apr 2022

ST6Gal-I–mediated sialylation of the EGFR modulates cell mechanics and enhances cancer invasion

For more than two decades, University of Alabama at Birmingham researcher Susan Bellis, Ph.D., has studied how the addition of sialic acid to various proteins increases cancer resistance and oncogenicity.

22 Apr 2022

Less PSA testing minimizes overdiagnosis but may lead to increase in metastatic prostate cancer cases

Over the past 15 years, public health authorities have downgraded recommendations for the prostate-specific antigen (PSA) test as a screening tool to reduce the overdiagnosis and overtreatment of men with low-grade prostate cancer.

22 Apr 2022

UNIGE biologists discover a factor that explains breast cancer metastases to the bones

A team of biologists led by UNIGE has discovered, for breast cancer, a factor that explains the spread of metastases to the bones.

21 Apr 2022

Researchers test an experimental treatment for metastatic cancer

Researchers at the University of Oklahoma are testing an experimental treatment for metastatic cancer focusing on pancreatic cancer.

20 Apr 2022

Newly discovered immune cell "soldier" could be a good target for immunotherapy

Despite the success of immunotherapy in helping many people with cancer, the majority of patients still do not respond to these treatments. There is need for continued research.

20 Apr 2022

Mutated gene found in breast cancer recurrences may help tumors to become more aggressive

A mutated gene found in more than 20% to 30% of breast cancer recurrences may help tumors become more aggressive and promote metastasis, according to a pair of new studies that uncover mechanisms behind these processes and point to new therapy targets.

20 Apr 2022

Noninvasive sound technology could lead to improved cancer outcomes in humans

Noninvasive sound technology developed at the University of Michigan breaks down liver tumors in rats, kills cancer cells and spurs the immune system to prevent further spread—an advance that could lead to improved cancer outcomes in humans.

18 Apr 2022

Researchers find novel inhibitors that may suppress oncogenesis of metastatic prostate cancer

Researchers have found that treating prostate cancer cells with novel cyclin-dependent kinase 19 (CDK19) and homologous cyclin-dependent kinase 8 (CDK8) inhibitors reduces their potential to migrate into and invade surrounding structures.

13 Apr 2022

Study finds molecular features responsible for the development of metastatic breast cancer

Susana Garcia-Recio, PhD, a research associate in the lab of Charles M. Perou, PhD, at UNC Lineberger Comprehensive Cancer Center, will present findings that identified molecular features responsible for the development and progression of metastatic breast cancer at the 2022 American Association for Cancer Research annual meeting. (Presentation: Abstract LB176/4, Tuesday, April 12, 3:20 p.m. ET, Room 217-219, Ernest N. Morial Convention Center in New Orleans.)

11 Apr 2022

UC researcher awarded renewal grant to continue the study of genetic drivers of breast cancer

A grant renewal for a University of Cincinnati researcher will help continue the study of genetic drivers of breast cancer and potential therapeutic targets.

7 Apr 2022

Cytoskeletal proteins work synergistically in the cell cortex to form intracellular networks

Investigators have discovered that two cytoskeletal proteins which were previously thought to function independently actually interact and form cytoskeletal networks within the cell surface, according to findings published in Proceedings of the National Academy of Sciences.

7 Apr 2022

Metastasis News and Research

Further Reading

Study uncovers new regulator of prostate cancer metastasis

New guideline provides guidance on the use of radiation therapy to treat patients with brain metastases

Scientists identify the role of phospholipid in maintaining epithelial cellular adhesion

How new Insights into ESR1 Mutant Breast Cancers may lead to Novel Therapy Targets

Using AI to predict how cancer may affect the probability of spinal fractures

Novel plug-and-play multi-organ chip can be customized to the patient

Combination therapy shows promise for treating triple-negative breast cancer

Researchers reveal how not-yet-malignant cells “turn on” and become metastatic breast cancer

Reprogrammed macrophages promote the settlement of breast cancer metastases in the lungs

ST6Gal-I–mediated sialylation of the EGFR modulates cell mechanics and enhances cancer invasion

Less PSA testing minimizes overdiagnosis but may lead to increase in metastatic prostate cancer cases

UNIGE biologists discover a factor that explains breast cancer metastases to the bones

Researchers test an experimental treatment for metastatic cancer

Newly discovered immune cell "soldier" could be a good target for immunotherapy

Mutated gene found in breast cancer recurrences may help tumors to become more aggressive

Noninvasive sound technology could lead to improved cancer outcomes in humans

Researchers find novel inhibitors that may suppress oncogenesis of metastatic prostate cancer

Study finds molecular features responsible for the development of metastatic breast cancer

UC researcher awarded renewal grant to continue the study of genetic drivers of breast cancer

Cytoskeletal proteins work synergistically in the cell cortex to form intracellular networks

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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