Progenitor Cells News and Research

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Study provides important new perspective on how we look at bladder cancer biology

Bladder cancer will kill upward of 170,000 people worldwide this year, but bladder cancer isn't fatal in the bladder. Instead, in order to be fatal the disease must metastasize to faraway sites. The question has been this: does localized, non-muscle invasive bladder cancer eventually become the more dangerous, muscle-invasive form of the disease, or are NMI and MI bladder cancers genetically distinct from the start?

17 Dec 2013

UCLA stem cell researchers track early development of human articular cartilage

Stem cell researchers from UCLA's Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have published the first study to identify the origin cells and track the early development of human articular cartilage, providing what could be a new cell source and biological roadmap for therapies to repair cartilage defects and osteoarthritis. These revolutionary therapies could reach clinical trials within three years.

13 Dec 2013

Researchers produce erythrocyte progenitor cells by transducing two genes into iPS and ES cells

By transducing two genes (c-MYC and BCL-XL) into iPS cells and ES cells, a Kyoto University research team led by Prof. Koji Eto at CiRA has succeeded in producing erythrocyte progenitor cells with almost unlimited ability to replicate in vitro, which they then differentiated successfully into mature erythrocytes. Although these erythrocytes consisted mostly of fetal-type hemoglobin, they were confirmed to have oxygen-carrying capacity and to have circulatory capacity following transfusion into mice.

6 Dec 2013

UCLA researchers identify cells involved in placenta development

Dr. Hanna Mikkola and researchers at UCLA's Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have identified a specific type of cell and a related cell communication pathway that are key to the successful growth of a healthy placenta. The findings could greatly bolster our knowledge about the potential causes of complications during pregnancy.

27 Nov 2013

EPCs: A promising therapy for type 1 diabetes

Pancreatic islet transplantation is a promising therapy for treating type 1 diabetes, but the majority of transplanted cells die soon after they are transplanted.

27 Nov 2013

Researchers identify progenitor cells that are vital for successful growth of healthy placenta

Dr. Hanna Mikkola and researchers at UCLA's Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have identified a novel progenitor cell and a related cell communication pathway that are key to the successful growth of a healthy placenta.

26 Nov 2013

Research: Notch protein plays essential role in triggering T-cell development

The lab of Avinash Bhandoola, PhD, professor of Pathology and Laboratory Medicine, has studied the origins of T cells for many years. One protein called Notch, which has well-known roles in the development of multiple tissues, plays an essential role in triggering T-cell development.

25 Nov 2013

GM-CSF therapy does not improve treadmill walking time in patients with peripheral artery disease

Joseph Poole, M.D., Ph.D., of the Emory University School of Medicine, Atlanta, and colleagues studied whether therapy with granulocyte-macrophage colony stimulating factor (GM-CSF), an agent that functions as a white blood cell growth factor, would improve walking performance in patients with symptomatic peripheral artery disease (a form of vascular disease in which there is partial or total blockage of an artery, usually one leading to a leg or arm).

19 Nov 2013

Study: Blood cell growth factor improves effects of exercise in patients with peripheral artery disease

A blood cell growth factor can boost the effects of exercise in improving mobility for patients with peripheral artery disease, a clinical study has shown.

19 Nov 2013

Scientists reveal surprising role for HDAC1 proteins in development of skin tumors

Findings by scientists from the Max F. Perutz Laboratories (MFPL) of the University of Vienna and the Medical University of Vienna reveal a surprising role for histone deacetylase 1 (HDAC1) - a member of a family of chromatin modifying proteins - in the development of skin tumors.

18 Nov 2013

Promethera Biosciences completes patient enrolment for first clinical trial of HepaStem

Promethera Biosciences, a Belgian biotechnology company developing Promethera HepaStem, a cell-based therapy for the treatment of liver-based metabolic diseases including Crigler-Najjar Syndrome and Urea Cycle Disorders, announces today the completion of patient enrolment for its first clinical trial.

12 Nov 2013

New zebrafish technique finds potential treatments for multiple diseases

Skeletal muscle has proved to be very difficult to grow in patients with muscular dystrophy and other disorders that degrade and weaken muscle. Researchers at Boston Children's Hospital's Stem Cell Program now report boosting muscle mass and reversing disease in a mouse model of Duchenne muscular dystrophy, using a "cocktail" of three compounds identified through a new rapid culture system. Adding the same compounds to stem cells derived from patients' skin cells, they then successfully grew human muscle cells in a dish.

8 Nov 2013

Stem cell therapy after traumatic brain injury promotes lasting cognitive improvement

A stem cell therapy previously shown to reduce inflammation in the critical time window after traumatic brain injury also promotes lasting cognitive improvement, according to preclinical research led by Charles Cox, M.D., at The University of Texas Health Science Center at Houston (UTHealth) Medical School.

4 Nov 2013

Epigenetics may be useful target to stop the growth, spread and relapse of cancer

A review article by researchers at Boston University School of Medicine suggests that epigenetics may be a useful target to stop the growth, spread and relapse of cancer. The findings are published online in Volume 14 of the International Journal of Molecular Science.

31 Oct 2013

Study reveals that tumors factors inhibit repair of damaged muscle fibers during cancer wasting

A new study reveals that tumors release factors into the bloodstream that inhibit the repair of damaged muscle fibers, and that this contributes to muscle loss during cancer wasting.

24 Oct 2013

Researchers develop innovative 3D method to grow miniature pancreas from progenitor cells

An international team of researchers from the University of Copenhagen have successfully developed an innovative 3D method to grow miniature pancreas from progenitor cells. The future goal is to use this model to help in the fight against diabetes. The research results has just been published in the scientific journal Development.

16 Oct 2013

New gene transfer strategy effective for achieving persistent immunotherapy to treat tumors

Cancer immunotherapy can successfully use the body's own immune system to kill tumor cells. But some current approaches to stimulate an antitumor immune response are short-lived, with limited clinical effectiveness. A new gene transfer strategy that introduces modified, immune-stimulating human stem cells is both feasible and effective for achieving persistent immunotherapy to treat leukemias and lymophomas, according to a study published in Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

11 Oct 2013

Researchers find ways to identify, isolate HCC progenitor cells before tumors become evident

For the first time, researchers at the University of California, San Diego School of Medicine have isolated and characterized the progenitor cells that eventually give rise to malignant hepatocellular carcinoma tumors - the most common form of liver cancer. The researchers found ways to identify and isolate the HCC progenitor cells long before actual tumors were apparent.

11 Oct 2013

Small interfering RNAs in mammals act as specific antiviral weapons

Many viral infections are nipped in the bud by the innate immune response. This involves specific proteins within the infected cell that recognize the virus and trigger a signalling cascade - the so-called interferon response. This activates a protective mechanism in neighbouring cells and often results in the death of the primarily infected cell.

11 Oct 2013

TSRI scientists identify set of compounds to treat multiple sclerosis in new way

Scientists at The Scripps Research Institute (TSRI) have identified a set of compounds that may be used to treat multiple sclerosis (MS) in a new way. Unlike existing MS therapies that suppress the immune system, the compounds boost a population of progenitor cells that can in turn repair MS-damaged nerve fibers.

10 Oct 2013

Progenitor Cells News and Research

Study provides important new perspective on how we look at bladder cancer biology

UCLA stem cell researchers track early development of human articular cartilage

Researchers produce erythrocyte progenitor cells by transducing two genes into iPS and ES cells

UCLA researchers identify cells involved in placenta development

EPCs: A promising therapy for type 1 diabetes

Researchers identify progenitor cells that are vital for successful growth of healthy placenta

Research: Notch protein plays essential role in triggering T-cell development

GM-CSF therapy does not improve treadmill walking time in patients with peripheral artery disease

Study: Blood cell growth factor improves effects of exercise in patients with peripheral artery disease

Scientists reveal surprising role for HDAC1 proteins in development of skin tumors

Promethera Biosciences completes patient enrolment for first clinical trial of HepaStem

New zebrafish technique finds potential treatments for multiple diseases

Stem cell therapy after traumatic brain injury promotes lasting cognitive improvement

Epigenetics may be useful target to stop the growth, spread and relapse of cancer

Study reveals that tumors factors inhibit repair of damaged muscle fibers during cancer wasting

Researchers develop innovative 3D method to grow miniature pancreas from progenitor cells

New gene transfer strategy effective for achieving persistent immunotherapy to treat tumors

Researchers find ways to identify, isolate HCC progenitor cells before tumors become evident

Small interfering RNAs in mammals act as specific antiviral weapons

TSRI scientists identify set of compounds to treat multiple sclerosis in new way

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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