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Researchers develop new hybrid method to study HIV protein involved in disease progression

More than 36 million people worldwide, including 1.2 million in the U.S., are living with an HIV infection. Today's anti-retroviral cocktails block how HIV replicates, matures and gets into uninfected cells, but they can't eradicate the virus.

3 Aug 2016

New drug treatment could reduce body weight in obese patients with rare genetic disorder

As part of a phase II study at Charité - Universitätsmedizin Berlin and the Berlin Institute of Health, two obese patients with a rare genetic disorder were given a drug treatment to stimulate the satiety center in the brain.

3 Aug 2016

E. coli K1 inhibits glucose transporters during meningitis, report scientists

Escherichia coli K1 (E. coli K1) continues to be a major threat to the health of young infants. Affecting the central nervous system, it causes neonatal meningitis by multiplying in immune cells, such as macrophages, and then disseminating into the bloodstream to subsequently invade the blood-brain barrier.

3 Aug 2016

Metabolic-checkpoint inhibitor combination approach may improve cancer therapies

Reprogramming of the molecular pathways underlying normal metabolism is essential for T cell infection-fighting function and for the immune system to form a "memory" of the microbes it has already encountered. But exactly how metabolism in exhausted T cells is maintained in chronic infections and cancer is a missing element in this line of research.

3 Aug 2016

Scientists engineer therapeutic system with two arms to get better hold on cancer target

Scientists have engineered a sort of biological barbell that can get inside cancer cells and do damage to two proteins that work independently and together to enable cancer's survival and spread.

3 Aug 2016

Advances in head and neck cancer treatments: an interview with Prof. Argiris

Patients with head and neck cancer usually present with locally advanced disease and often require more than one type of treatment, which may include surgery, radiotherapy, and chemotherapy.

3 Aug 2016

Study shows diabetes drug ineffective in improving condition of patients with advanced heart failure

In an attempt to correct defects in the energy generation that contribute to poor pump function among heart failure patients, researchers examined whether the diabetes drug liraglutide, could improve the condition of patients with advanced heart failure.

2 Aug 2016

TSRI study unveils new twist in immune biology

A new study, led by scientists at The Scripps Research Institute, reveals a surprising twist in immune biology.

2 Aug 2016

Overcoming gene silencing barriers to target neurological conditions: an interview with Dr Errol de Souza

Many gene mutations that cause neurological disorders have been identified. For example, in a rare neurological disorder such as Huntington’s disease, an autosomal dominant mutation through expansion of CAG (cytosine-adenine-guanine) triplet repeats in the gene coding for the Huntingtin protein results in abnormal protein production.

1 Aug 2016

Malfunctioning of molecular signaling system suppresses mature blood cells battling against sepsis

When the body encounters an infection, a molecular signaling system ramps up the body's infection-fighting system to produce more white blood cells to attack invading bacteria.

30 Jul 2016

T-cell technology could be used to treat ovarian tumors with no adverse effects

With only incremental improvements in ovarian cancer survival over the last 40 years, there is a clear need for new treatment options with long-lasting results. Many researchers have turned toward the development of immunotherapies that direct T-cells to selectively eliminate ovarian tumor cells, but an appropriate therapeutic target for ovarian cancers has remained elusive.

29 Jul 2016

Novel conjugate therapy shows promise in destroying ALL cells with few side effects

Researchers at UC Davis and Ionis Pharmaceuticals have developed a hybrid treatment that harnesses a monoclonal antibody to deliver antisense DNA to acute lymphoblastic leukemia (ALL) cells and that may lead to less toxic treatments for the disease.

29 Jul 2016

Blood pressure hormone system important for cardiovascular health can promote obesity

New research by University of Iowa scientists helps explain how a hormone system often targeted to treat cardiovascular disease can also lower metabolism and promote obesity.

29 Jul 2016

Study reports sampling method used for new breast cancer tests may need to be refined

Not only is breast cancer more than one disease, but a single breast cancer tumor can vary within itself, a finding that University of Pittsburgh Cancer Institute researchers discovered has the potential to lead to very different patient treatment plans depending on the tumor sample and diagnostic testing used.

28 Jul 2016

FDA approves new injection to improve blood sugar levels in adults with type 2 diabetes

The U.S. Food and Drug Administration approved Adlyxin (lixisenatide), a once-daily injection to improve glycemic control (blood sugar levels), along with diet and exercise, in adults with type 2 diabetes.

28 Jul 2016

Updated guidelines for breast cancer increase number of patients who test HER2-positive

Changes to HER2 testing guidelines for breast cancer in 2013 significantly increased the number of patients who test HER2-positive, according to a new study by Mayo Clinic researchers published in the Journal of Clinical Oncology.

28 Jul 2016

TSRI scientists develop new dual-targeting drug candidate for treating diabetes and bone disease

In addition to its more obvious ills, type 2 diabetes is a condition closely associated with bone fractures, increasing the risk of fractures twofold. To make matters worse, certain anti-diabetic drugs further increase this risk, particularly in postmenopausal women, severely limiting their treatment options.

28 Jul 2016

Liquid biopsies hold potential for detecting NSCLC EGFR mutations, predicting cancer recurrence

Three manuscripts published in the recent issue of the Journal of Thoracic Oncology, the official journal of the International Association for the Study of Lung Cancer, explored the versatility of liquid biopsies by identifying EGFR mutations using circulating tumor DNA (ctDNA) in urine and plasma and examining circulating tumor cells (CTCs) in plasma to predict the risk of lung cancer recurrence after surgical resection.

26 Jul 2016

New neuroprotective compounds may prevent development of epilepsy

A team led by Nicolas Bazan, MD, PhD, Boyd Professor and Director of LSU Health New Orleans' Neuroscience Center of Excellence, has developed neuroprotective compounds that may prevent the development of epilepsy.

22 Jul 2016

New imaging tool may help detect presence of androgen receptor in prostate cancer patients

Prostate cancer is one of the most common cancers in men. Tumor growth is critically regulated by the androgen receptor, and treatment strategies to lower androgens, such as testosterone, are a mainstay of clinical treatment.

21 Jul 2016

Receptor News and Research

Researchers develop new hybrid method to study HIV protein involved in disease progression

New drug treatment could reduce body weight in obese patients with rare genetic disorder

E. coli K1 inhibits glucose transporters during meningitis, report scientists

Metabolic-checkpoint inhibitor combination approach may improve cancer therapies

Scientists engineer therapeutic system with two arms to get better hold on cancer target

Advances in head and neck cancer treatments: an interview with Prof. Argiris

Study shows diabetes drug ineffective in improving condition of patients with advanced heart failure

TSRI study unveils new twist in immune biology

Overcoming gene silencing barriers to target neurological conditions: an interview with Dr Errol de Souza

Malfunctioning of molecular signaling system suppresses mature blood cells battling against sepsis

T-cell technology could be used to treat ovarian tumors with no adverse effects

Novel conjugate therapy shows promise in destroying ALL cells with few side effects

Blood pressure hormone system important for cardiovascular health can promote obesity

Study reports sampling method used for new breast cancer tests may need to be refined

FDA approves new injection to improve blood sugar levels in adults with type 2 diabetes

Updated guidelines for breast cancer increase number of patients who test HER2-positive

TSRI scientists develop new dual-targeting drug candidate for treating diabetes and bone disease

Liquid biopsies hold potential for detecting NSCLC EGFR mutations, predicting cancer recurrence

New neuroprotective compounds may prevent development of epilepsy

New imaging tool may help detect presence of androgen receptor in prostate cancer patients

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