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Novel drug combination shows promise in treating pancreatic cancer

Mutations in the KRAS gene are the major driver of pancreatic cancer. The resulting protein controls multiple signaling pathways involved in cell growth and survival. In cancer, the gene is mutated to be permanently "on," driving cells to excessively multiply and form tumors.

28 Jun 2023

Single-cell transcriptomic analysis reveals specific cellular signatures for kidney transplant rejection

Imagine a day when a urine test could inform a doctor precisely why a kidney transplant patient was experiencing organ rejection and suggest the best medication for specifically addressing the problem.

28 Jun 2023

New nanoparticle could improve the delivery of mRNA-based vaccines

Johns Hopkins Medicine scientists say they have developed a nanoparticle - an extremely tiny biodegradable container - that has the potential to improve the delivery of messenger ribonucleic acid (mRNA)-based vaccines for infectious diseases such as COVID-19, and vaccines for treating non-infectious diseases including cancer.

28 Jun 2023

SARS-CoV-2 mRNA vaccination induces an immune response in the nasal mucosa, study finds

Respiratory viruses are known for their ability to enter the body through the eyes, nose, or mouth. Our bodies know that, too.

28 Jun 2023

New radionuclide-based agent offers hope for treating a variety of cancers

A newly discovered radionuclide-based agent (CB-2PA-NT) has been shown to have high tumor uptake, sustained tumor retention, and high contrast in preclinical models, making it a prime candidate for a novel theranostics approach.

27 Jun 2023

New method could revolutionize the delivery of antioxidants to stem cells

As we age, our bodies change and degenerate over time in a process called senescence. Stem cells, which have the unique ability to change into other cell types, also experience senescence, which presents an issue when trying to maintain cell cultures for therapeutic use.

27 Jun 2023

New technique shows potential to generically treat several kinds of cancer

Researchers led by Katsunori Tanaka at the RIKEN Cluster for Pioneering Research (CPR) in Japan and Hiromitsu Haba at the RIKEN Nishina Center for Accelerator-Based Science (RNC) have developed a new technique that has the potential to generically treat several kinds of cancer, with fewer negative side effects than currently available methods.

27 Jun 2023

GREB1 gene key to liver cancer development, study finds

The development of hepatocellular carcinoma, liver cancer, is known to involve abnormal activation of a signaling pathway called Wnt; however, the underlying mechanisms have not been fully understood, until now.

27 Jun 2023

Growing up in poverty may influence the wiring of a child's brain, study suggests

A new study from Washington University School of Medicine in St. Louis suggests that growing up in poverty may influence the wiring of a child's brain.

27 Jun 2023

Mastering repeatability in cell culture with INTEGRA Biosciences’ WELLJET peristaltic pump dispenser

INTEGRA Biosciences’ WELLJET reagent dispenser and EasySnap™ dispensing cassettes offer a unique solution to common issues in cell-based workflows.

From INTEGRA Biosciences 27 Jun 2023

New nanocarriers could revolutionize tuberculosis treatment

Therapy of the dangerous infectious disease of tuberculosis faces the challenge of pathogens frequently being resistant to several common antibiotics.

27 Jun 2023

Are a high-refined carbohydrate diet and the alterations resulting from its intake linked to small intestine changes?

Researchers investigated whether a high-refined carbohydrate diet and associated metabolic alterations could cause small intestinal dysregulation.

27 Jun 2023

mRNA rabies vaccine induces durable immune response in macaques

Novel mRNA vaccine for rabies shows enhanced immune response with higher antibody levels and improved cross-neutralization, indicating potential for a broadly protective vaccine against related lyssavirus strains.

26 Jun 2023

New study offers clues on how to future-proof covid-19 vaccines

New research examining how frequently our bodies produce broadly neutralizing antibodies (bnAbs) capable of thwarting a range of SARS-CoV-2 variants offers clues on the strategy tweaks that could potentially future-proof COVID-19 vaccines.

26 Jun 2023

New study shows promise for diphenyl ditelluride as anti-cancer drug

A new research paper was published in Oncotarget's Volume 14 on June 21, 2023, entitled, "Diphenyl ditelluride anticancer activity and DNA topoisomerase I poisoning in human colon cancer HCT116 cells."

26 Jun 2023

Novel biomaterials approach reveals how mechanical forces shape T cell fate

The successful campaign of adoptive T cell therapies, a type of immunotherapy in which immune T cells are collected from a patient, enhanced outside of the body, and reinfused back into the same patient, especially against blood cancers is well under way.

26 Jun 2023