Genes News and Research

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One dose of VSV-vectored vaccine prevents SARS-CoV-2 replication in hamsters

A new preprint research paper posted to the bioRxiv server describes a viral vector vaccine candidate's efficacy to protect against SARS-CoV-2 replication in a hamster model.

3 Feb 2021

Genetic changes linked to neurodevelopmental disabilities, cerebral palsy

Researchers have discovered a strong link between genetic changes known to cause neurodevelopmental disabilities and cerebral palsy.

2 Feb 2021

Evolutionary history reveals the function of fish and human bitter receptors

To evaluate the chemical composition of food from a physiological point of view, it is important to know the functions of the receptors that interact with food ingredients.

2 Feb 2021

Lysosomal-immune axis associated with COVID-19 severity

New research suggests the modulation of lysosomal-immune pathways may present a novel drug-targeting strategy to attenuate SARS-CoV-2 infections.

2 Feb 2021

Gene mutations may explain the poorer outcomes in Hispanic and Latino children with leukemia

A combination of genetic mutations may explain the higher incidence of and poorer outcomes from pediatric leukemia in Hispanic and Latino children, according to Penn State College of Medicine researchers.

2 Feb 2021

Breast cancer‐on‐a‐chip to test the effectiveness of checkpoint inhibitor drugs

There are many mechanisms by which the body responds to foreign invaders. One of these involves the T-cells of the immune system, which have a number of different proteins on their surface called "checkpoint proteins."

2 Feb 2021

ZyCoV-D DNA vaccine immunogenic against SARS-CoV-2 in animal models

In the absence of effective therapeutics or preventives, vaccines have become the focus of attention. Though over 170 vaccines are in preclinical and about 60 in clinical development, very few are based on plasmid DNA technology. However, a new preprint research paper posted to the bioRxiv* server reports the immunogenicity of a DNA vaccine candidate.

2 Feb 2021

Elevated ACE2 and inflammation levels increase risk for pregnant women infected with SARS-CoV-2

Among the hundred million or so cases of coronavirus disease 2019 (COVID-19) that have occurred since the pandemic began, pregnant women have been a conspicuous risk group. However, the exact nature of the risk they and their fetuses face, and the mechanism by which it operates, is far from clear.

2 Feb 2021

Synthetic biology can help create complex embryo

Richard Feynman, one of the most respected physicists of the twentieth century, said "What I cannot create, I do not understand". Not surprisingly, many physicists and mathematicians have observed fundamental biological processes with the aim of precisely identifying the minimum ingredients that could generate them. One such example are the patterns of nature observed by Alan Turing.

2 Feb 2021

Study: Bacteria living on toothbrush reflect oral hygiene, not the toilet aerosols

Good news: The bacteria living on your toothbrush reflect your mouth - not your toilet.

1 Feb 2021

Study explains why people of African descent are less likely to find bone marrow donors

A paper by a multidisciplinary team of scientists affiliated with various Brazilian institutions, including the University of São Paulo (USP) and the National Cancer Institute (INCA), shows that people of African descent are less likely to find a donor in the National Register of Voluntary Bone Marrow Donors (REDOME) than people with predominantly European ancestry.

1 Feb 2021

Study discovers promising therapeutic agent to inhibit melanoma progression

There have been great advances in treating melanoma over the past five years, however, even with these treatments many patients quickly develop drug resistance and die from their disease.

1 Feb 2021

An integrated approach could pave the way for future control of Alzheimer's disease

This new pioneering study by Prof. Ricardo Maccioni and coworkers of the International Center for Biomedicine, "New Frontiers in the prevention, diagnosis and treatment of Alzheimer´s disease" was published in the special issue of Latin American investigators of the Journal of Alzheimer's Disease.

1 Feb 2021

Life-threatening genetic immunodeficiency reversed by a rare DNA change

Researchers have revealed how a rare DNA change rebalanced the immune system of patients with a life-threatening genetic immunodeficiency.

1 Feb 2021

Gene panel is effective at identifying problematic genes in common leukemia

A gene panel that looks for about 10 times the number of cancer-causing genes as panels currently used to diagnose and fine-tune treatment for a variety of cancers is effective at identifying problematic genes in the most common leukemia, investigators report.

1 Feb 2021

Phase III study of (m)RNA expression did not confer significant advantage for stage II-III lung cancer

A phase III study examining whether messenger (m)RNA expression correlated with sensitivity or resistance to chemotherapy did not confer a statistically significant advantage in overall survival for patients with resected stage II-III non-small cell lung cancer (NSCLC), according to research presented at the International Association for the Study of Lung Cancer World Conference on Lung Cancer.

31 Jan 2021

Study reveals effective therapeutic strategy to prevent colorectal cancer progression

Nagoya University researchers and colleagues have revealed that colorectal cancer tissues contain at least two types of fibroblasts (a type of cells found in connective tissue), namely, cancer-promoting fibroblasts and cancer-restraining fibroblasts, and that the balance between them is largely involved in the progression of colorectal cancer.

30 Jan 2021

Genes News and Research

One dose of VSV-vectored vaccine prevents SARS-CoV-2 replication in hamsters

Genetic changes linked to neurodevelopmental disabilities, cerebral palsy

Evolutionary history reveals the function of fish and human bitter receptors

Lysosomal-immune axis associated with COVID-19 severity

Gene mutations may explain the poorer outcomes in Hispanic and Latino children with leukemia

Breast cancer‐on‐a‐chip to test the effectiveness of checkpoint inhibitor drugs

ZyCoV-D DNA vaccine immunogenic against SARS-CoV-2 in animal models

Elevated ACE2 and inflammation levels increase risk for pregnant women infected with SARS-CoV-2

Synthetic biology can help create complex embryo

Study: Bacteria living on toothbrush reflect oral hygiene, not the toilet aerosols

Study explains why people of African descent are less likely to find bone marrow donors

Study discovers promising therapeutic agent to inhibit melanoma progression

An integrated approach could pave the way for future control of Alzheimer's disease

Life-threatening genetic immunodeficiency reversed by a rare DNA change

Gene panel is effective at identifying problematic genes in common leukemia

Phase III study of (m)RNA expression did not confer significant advantage for stage II-III lung cancer

Study reveals effective therapeutic strategy to prevent colorectal cancer progression

RPS-12 protein overproduction appears to trigger breast cancer and other malignancies

Scientists study how different genes dance to the circadian rhythm

New method identifies important mutations behind hereditary non-polyposis colorectal cancer

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