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Studies in non-human primates provide more predictive results in genetic causes of blindness

Many gene therapy-based approaches are in development to combat genetic and other causes of blindness and vision loss, and much can be learned about the safety and effectiveness of these promising new therapies by studying them first in non-human primates before initiating clinical trials, as shown by the results of a study published in Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

29 Dec 2016

Super-resolution fluorescence microscopy sheds light on brain’s molecular mechanism

Advances in microscopy techniques have often triggered important discoveries in the field of neuroscience, enabling vital insights in understanding the brain and promising new treatments for neurodegenerative diseases such as Alzheimer's and Parkinson's.

29 Dec 2016

Study reports volume and cost of in-home care for children with special medical conditions

U.S. families provide nearly $36 billion annually in uncompensated medical care at home to children who have special health care needs, such as muscular dystrophy and cystic fibrosis, according to a large national study.

28 Dec 2016

Military health system to test U-M-developed V-BID approach

A health care reform idea originated by University of Michigan faculty will get a major test among members of the nation's military and their families, thanks to a provision in the national defense spending bill signed by President Obama on Friday.

28 Dec 2016

Whitehead Institute researchers identify mechanism underlying cancer drug-resistance

The use of proteasome inhibitors to treat cancer has been greatly limited by the ability of cancer cells to develop resistance to these drugs.

27 Dec 2016

Study tracks parents' unpaid time assisting children with special health care needs

About half of U.S. children with special health care needs -- 5.6 million children -- receive medical care from uncompensated family members worth billions of dollars, finds a large national study led by Boston Children's Hospital and the University of Southern California (USC).

27 Dec 2016

New research points to lncRNA's key role in helping control cellular processes

Scientific research over the past decade has concentrated almost exclusively on the 2 percent of the genome's protein coding regions, virtually ignoring the other 98 percent, a vast universe of non-coding genetic material previously dismissed as nothing more than 'junk.'

27 Dec 2016

Ionis announces FDA approval of first SMA drug in the U.S for pediatric and adult patients

Ionis Pharmaceuticals, Inc. announced today that the U.S. Food and Drug Administration has approved SPINRAZATM (nusinersen) under Priority Review for the treatment of spinal muscular atrophy (SMA) in pediatric and adult patients.

26 Dec 2016

Linking human genome sequences to EHR information could influence clinical medicine, says expert

The value of intersecting the sequencing of individuals' exomes or full genomes to find rare genetic variants -- on a large scale -- with their detailed electronic health record information has "myriad benefits, including the illumination of basic human biology, the early identification of preventable and treatable illnesses, and the identification and validation of new therapeutic targets," wrote Daniel J. Rader, MD, chair of the Department of Genetics, in the Perelman School of Medicine at the University of Pennsylvania, in Science this week, with Scott M. Damrauer, MD, an assistant professor of Surgery at Penn and the Veterans Affairs Medical Center in Philadelphia.

23 Dec 2016

New TSRI study shows how Piezo2 protein plays critical role in sensing lung expansion

The new study might help shed light on sudden infant death syndrome (SIDS) in human babies, which is thought to be associated with dysfunctional airway sensory neurons.

22 Dec 2016

New detection method could lead to noninvasive diagnosis of Creutzfeldt-Jakob disease

The detection of prions in the blood of patients with variant Creutzfeldt-Jakob disease could lead to a noninvasive diagnosis prior to symptoms and a way to identify prion contamination of the donated blood supply, according to researchers at McGovern Medical School at The University of Texas Health Science Center at Houston.

22 Dec 2016

Mount Sinai researchers laying groundwork to find effective treatment for Zika virus

Researchers at the Icahn School of Medicine at Mount Sinai are working on the basic science that lays the groundwork to finding a way to treat and prevent the Zika virus, a global health risk.

22 Dec 2016

New research offers valuable insight for developing more effective drugs to treat IBD

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the intestine that includes Crohn's disease and ulcerative colitis.

22 Dec 2016

UT Southwestern researchers find new way to combat multidrug-resistant bacteria in burn injuries

A new way to fight multidrug-resistant bacteria by blinding them rather than killing them proved highly effective in a model of burn injuries, UT Southwestern Medical Center research shows.

21 Dec 2016

Clinical study tests adult stem cell therapy for infants with congenital HLHS

In a first-in-children randomized clinical study, medical researchers at the University of Maryland School of Medicine and the Interdisciplinary Stem Cell Institute at the University of Miami Miller School of Medicine have begun testing to see whether adult stem cells derived from bone marrow benefit children with the congenital heart defect hypoplastic left heart syndrome (HLHS).

21 Dec 2016

Study finds chances for recovery of women with anorexia or bulimia nervosa

A study from Massachusetts General Hospital (MGH) investigators finds that, contrary to what is often believed, around two thirds of women with anorexia nervosa or bulimia nervosa will eventually recover from their eating disorders.

21 Dec 2016

Simple sniff test can enhance accuracy of diagnosing Alzheimer's disease

Tests that measure the sense of smell may soon become common in neurologists' offices.

20 Dec 2016

Bionic pancreas system manages blood sugar levels in patients with type 1 diabetes living at home

The bionic pancreas system developed by Boston University investigators proved better than either conventional or sensor-augmented insulin pump therapy at managing blood sugar levels in patients with type 1 diabetes living at home, with no restrictions, over 11 days.

20 Dec 2016

Holiday tips and gift suggestions for caregivers, families of AD patients

The holidays are supposed to be a time of joy and celebration, but we all know they can be stressful even under the best of circumstances.

20 Dec 2016

Researchers use CRISPR-based genetic screening to identify three promising HIV treatment targets

Investigators from Whitehead Institute, the Ragon Institute of MGH, MIT and Harvard and the Broad Institute of MIT and Harvard have used CRISPR-Cas9 gene-editing technology to identify three promising new targets for treatment of HIV infection.

20 Dec 2016

Medical School News and Research

Studies in non-human primates provide more predictive results in genetic causes of blindness

Super-resolution fluorescence microscopy sheds light on brain’s molecular mechanism

Study reports volume and cost of in-home care for children with special medical conditions

Military health system to test U-M-developed V-BID approach

Whitehead Institute researchers identify mechanism underlying cancer drug-resistance

Study tracks parents' unpaid time assisting children with special health care needs

New research points to lncRNA's key role in helping control cellular processes

Ionis announces FDA approval of first SMA drug in the U.S for pediatric and adult patients

Linking human genome sequences to EHR information could influence clinical medicine, says expert

New TSRI study shows how Piezo2 protein plays critical role in sensing lung expansion

New detection method could lead to noninvasive diagnosis of Creutzfeldt-Jakob disease

Mount Sinai researchers laying groundwork to find effective treatment for Zika virus

New research offers valuable insight for developing more effective drugs to treat IBD

UT Southwestern researchers find new way to combat multidrug-resistant bacteria in burn injuries

Clinical study tests adult stem cell therapy for infants with congenital HLHS

Study finds chances for recovery of women with anorexia or bulimia nervosa

Simple sniff test can enhance accuracy of diagnosing Alzheimer's disease

Bionic pancreas system manages blood sugar levels in patients with type 1 diabetes living at home

Holiday tips and gift suggestions for caregivers, families of AD patients

Researchers use CRISPR-based genetic screening to identify three promising HIV treatment targets

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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