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Abnormally low level of SMN protein linked to movement problems in spinal muscular atrophy

An abnormally low level of a protein in certain nerve cells is linked to movement problems that characterize the deadly childhood disorder spinal muscular atrophy, new research in animals suggests.

12 Apr 2012

First Edition: April 12, 2012

Today's headlines include reports about Massachusetts' health reform's sixth birthday.

From Medtronic 12 Apr 2012

PPIs improve sleep and daytime quality of life for sufferers of GERD

The use of proton pump inhibitors improves the sleep and daytime quality of life for sufferers of gastroesophageal reflux disease, according to a systematic literature review in the April 2012 issue of Otolaryngology-Head and Neck Surgery.

12 Apr 2012

Scientists discover mutation limited to brain tissue that causes HMG

Scientists have discovered a mutation limited to brain tissue that causes hemimegalencephaly (HMG), a condition where one half of the brain is enlarged and dysfunctional, leading to intellectual disability and severe epilepsy.

12 Apr 2012

Hi-C sequencing decodes 3-D structure of DNA folds in chromosomes

Chromosomes are strands of DNA that contain the blueprint of all living organisms. Humans have 23 pairs of chromosomes that instruct how genes are regulated during development of the human body. While scientists have developed an understanding of the one-dimensional structure of DNA, until today, little was known about how different parts of DNA are folded next to each other inside the nucleus.

12 Apr 2012

Screen time linked with obesity in children

Approximately 20 percent of adolescents in the U.S. today are obese or overweight. With the number of obese and overweight younger children close behind, this epidemic has lasting implications for the future.

12 Apr 2012

The urgency of autism: Progress in combating it, even as diagnoses increase

News outlets examine progress being made in diagnosing autism and understanding its possible causes.

12 Apr 2012

Eye test to detect heart disease early

Scientists at the University of Edinburgh have developed the test which scans blood vessels in the retina at the back of the eyes. They are now launching a study involving more than 1,000 patients to see if the test is reliable.

11 Apr 2012

Too frequent dental X-rays linked to higher risk of brain tumors

A new study has found that people who received frequent dental x-rays in the past have an increased risk of developing meningioma - a type of brain tumor. The study was published online Tuesday in Cancer, a peer-reviewed journal of the American Cancer Society.

11 Apr 2012

Losartan may not increase risk of all-cause mortality in heart failure patients

Although observational studies have suggested that losartan, a drug used primarily for the treatment of hypertension, may be associated with an increased risk of death among patients with heart failure compared with other medications in the same class of drugs (angiotensin II receptor blockers [ARBs]), an analysis that included nearly 6,500 patients found that overall, use of losartan was not associated with increased all-cause death or cardiovascular death compared with use of the ARB candesartan, according to a study in the April 11 issue of JAMA.

11 Apr 2012

Mothers tend to be more critical of children with obsessive-compulsive disorder

A new study from Case Western Reserve University finds mothers tend to be more critical of children with obsessive-compulsive disorder than they are of other children in the family. And, that parental criticism is linked to poorer outcomes for the child after treatment.

11 Apr 2012

Genes and obesity link found in kids

The team of researchers used genome-wide association techniques and found that several genetic variants associated with adult obesity are also active in childhood obesity, according to Struan Grant of the Children's Hospital of Philadelphia and colleagues. The analysis found two new genetic variants that had not been previously associated with obesity, Grant and colleagues reported online in Nature Genetics. The findings show that “there is indeed a genetic signature of childhood obesity,” Grant said. “It's not purely lifestyle.”

10 Apr 2012

Autism linked to maternal obesity: Study

The study published Monday in the journal Pediatrics shows that compared to non-obese mothers those who were obese before pregnancy had a 1.6 times increase in the likelihood of having a child with autism.

10 Apr 2012

Gates Foundation co-chair Melinda Gates delivers TEDxChange speech on access to contraceptives

On Thursday at the TEDxChange conference in Berlin, Germany, Melinda Gates, co-chair of the Bill & Melinda Gates Foundation, "delivered a powerful case for universal access to contraception for women around the world who need and want it," the Seattle Post-Intelligencer reports.

10 Apr 2012

To improve global health, toilets must be redesigned to work without connection to sanitation grid

"The toilet is a magnificent thing. ... Unfortunately it is an impractical luxury for about two-thirds of the world's seven billion people because it relies on connections to water and sewerage systems that must be built and maintained at great expense," a Bloomberg editorial writes.

10 Apr 2012

Two CNVs may increase risk of aggressive prostate cancer

An international research team led by Weill Cornell Medical College investigators have discovered two inherited-genetic deletions in the human genome linked to development of aggressive prostate cancer.

10 Apr 2012

More than 60% of breast cancer survivors report post-treatment complications

More than 60 percent of breast cancer survivors report at least one treatment-related complication even six years after their diagnosis, according to a new study led by a researcher from the Perelman School of Medicine at the University of Pennsylvania.

10 Apr 2012

Regular dental x-rays increase risk of meningioma in the U.S.

People who received frequent dental x-rays in the past have an increased risk of developing the most commonly diagnosed primary brain tumor in the United States. That is the finding of a study published early online in Cancer, a peer-reviewed journal of the American Cancer Society.

10 Apr 2012

Five significant genetic associations for hypothyroidism found

Using its unique online research platform, 23andMe, a leading personal genetics company, has found five significant genetic associations for hypothyroidism in the largest known genome-wide association study of hypothyroidism conducted to date. The details of the study are now available online in the journal PLoS ONE.

9 Apr 2012

First study to examine links between neurodevelopmental disorders and maternal metabolic conditions

A major study of the relationships between maternal metabolic conditions and the risk that a child will be born with a neurodevelopmental disorder has found strong links between maternal diabetes and obesity and the likelihood of having a child with autism or another developmental disability.

9 Apr 2012