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Olig1 and Olig2 genes are associated with Down syndrome, scientists identify

Down syndrome is a well known cause of mental retardation and other medical problems, including early onset of Alzheimer disease. It has long been known that Down syndrome is associated with an individual having an additional copy of chromosome 21. Research findings reported in the July 18 advanced online publication of Nature Neuroscience have narrowed down the critical genetic elements responsible for some aspects of Down syndrome.

19 Jul 2010

Researchers to receive $1.2M from Susan G. Komen for the Cure for breast cancer research

Four researchers from Detroit, Michigan's Barbara Ann Karmanos Cancer Institute and Wayne State University will receive a total of $1.2 million from Susan G. Komen for the Cure to help advance research to better detect, prevent and eliminate breast cancer. The $1.2 million awarded to these outstanding scientists is part of the $59 million portfolio of research grants that Susan G. Komen for the Cure has awarded this year alone to scientists across the globe to help accelerate innovative breast cancer research.

17 Jul 2010

New mechanism that drives development of B-lymphocytes in bone marrow discovered

Scientists from the Department of Molecular Immunology, Institute of Biology III, Faculty of Biology and the Centre for Biological Signalling Studies, BIOSS have discovered a new mechanism that drives the development of B-lymphocytes in our bone marrow. B-lymphocytes are an important part of our immune system. Upon their activation they produce the antibodies protecting us from infections.

17 Jul 2010

Low-dose method of performing CT heart scans developed at Porter Adventist Hospital

As warnings and concern increase over the health risks of commonly used scanning tests involving high doses of radiation, radiologists and scientists are seeking ways to improve the safety of the tools they use in diagnosing disease.

17 Jul 2010

FDA warns public over safety of stolen Advair Diskus inhalers

The FDA is warning the public that certain Advair Diskus inhalers stolen from a distribution warehouse in 2009 have been found in some pharmacies. The safety and effectiveness of the stolen inhalers cannot be assured and they should not be used.

17 Jul 2010

GABA disrupts working memory in neurofibromatosis type 1 patients

Imagine if your brain lost its working memory - the ability to hold and manipulate information in your mind's eye. That's the plight faced by millions of people with neurofibromatosis type 1, or NF1. The genetic condition affects one in 3,500 people and is the most common cause of learning disabilities.Now a UCLA research team has uncovered new clues about how NF1 disrupts working memory. Published in the July 12 online edition of Proceedings of the National Academy of Sciences, the findings suggest a potential drug target for correcting NF1-related learning disabilities.

17 Jul 2010

Report on current state of research in information security and privacy in healthcare

Information security and privacy in the healthcare sector is an issue of growing importance but much remains to be done to address the various issues raised by healthcare consumers regarding privacy and security and the providers' perspective of regulatory compliance.

17 Jul 2010

Cetuximab recommended for colorectal cancer tumors without mutation in KRAS gene

In a report published in the July 2010 issue of the American Society for Clinical Oncology Post, new recommendations on the use of the drug cetuximab have been issued after officials halted enrollment in a phase III clinical trial in patients with spread of colon cancer into regional lymph nodes whose tumors had been surgically removed.

17 Jul 2010

CCTP focuses on identifying, testing drugs for cancer stem cell treatment

Cancer and stem cell biology researchers at the University of Colorado are launching the nation's first program focused on identifying and testing drugs that target and destroy cells thought to be at the root of cancer-cancer stem cells (CSCs).The Cancer Stem Cell-Directed Clinical Trials Program (CCTP) is a collaboration between the University of Colorado Cancer Center and the Charles C. Gates Center for Regenerative Medicine and Stem Cell Biology, both located at the University of Colorado School of Medicine.

17 Jul 2010

AMPK may regulate epigenetic mechanism: Research

AMP-activated protein kinase, or AMPK, is a master regulator protein of metabolism that is conserved from yeast to humans. When a cell is low on fuel, AMPK shuts down processes that use energy and turns on processes that produce energy.Biologists have been studying how AMPK works for several decades and know that once it is activated, AMPK turns on a large number of genes by passing the "make more energy" message through numerous signaling cascades in the cell. What was not known, until now, was that AMPK also works via an epigenetic mechanism to slow down or stop cell growth.

17 Jul 2010

ICON opens purpose-built clinical pharmacology unit within CMFT campus

ICON plc,, a global provider of outsourced development services to the pharmaceutical, biotechnology and medical device industries, today announced the official opening of a purpose-built clinical pharmacology unit within the Central Manchester University Hospitals Foundation Trust (CMFT) campus in Manchester, UK. Initial studies in the unit utilising translational medicine methodologies to expedite drug development projects began in June, and already 110 volunteers have participated in studies there.

17 Jul 2010

Ronald Reagan UCLA Medical Center ranks first: U.S. News & World Report survey

Ronald Reagan UCLA Medical Center ranks as one of the top five American hospitals -- and the best hospital in the western United States for the 21st consecutive year -- according to a U.S. News & World Report survey that reviewed patient-outcomes data, reputation among physicians and other care-

17 Jul 2010

Hospitals fight for primary care docs as bad nurses allowed to continue work

Orlando Sentinel: For primary care specialties, residency programs fight to capture the attention of potential residents who are in high demand.

17 Jul 2010

FDA can promote personalized medicine by identying gaps in laboratory operations: ACLA

The Food and Drug Administration can promote progress toward personalized medicine by approaching the oversight of laboratory developed tests (LDTs) in a focused, flexible, and balanced way according to the American Clinical Laboratory Association (ACLA). ACLA, which represents the nation's leading clinical laboratories, says that the factors supporting this approach include the growing role that such tests play in clinical decision making, especially in the area of new advanced diagnostics that derive from the mapping of the human genome and help fulfill the promise of personalized medicine.

17 Jul 2010

Research findings may help identify human TOR kinase inhibitors

A parasite estimated to afflict as many as 12 million people worldwide relies on a family of genes that should make it vulnerable to compounds developed to treat cancer and other disorders, researchers at Washington University School of Medicine in St. Louis have found.

17 Jul 2010

Today's OpEds: Shift entitlement spending to the states; The lack of a GOP health plan; Battling tobacco

The U.S. fiscal path is unsustainable, primarily because of out-of-control entitlement spending. … At some point, therefore, the economy is due to crash unless Washington reins in spending. One way to avoid this outcome would be to transfer entitlement programs to the states ... failure to slash entitlements could mean a bankrupt economy. When that happens, it's sure to be the poor who suffer the most (Jeffrey Miron, 7/16).

17 Jul 2010

Recent releases in Global Health

As part of a series in advance of AIDS 2010, the "Science Speaks" blog features an interview with U.S. Global AIDS Coordinator Eric Goosby "about his expectations for the conference, what was behind the Uganda problem with shortages of AIDS medicine, and whether The New York Times was right when it reported in May that the Ugandan drug shortfall was 'the first example … of how the war on AIDS is falling apart.'"

16 Jul 2010

Best practices for increasing clinical trial site and patient recruitment

PRA International, a leading Clinical Research Organization, will host an audio conference on the best practices for increasing clinical trial site and patient recruitment on 22 July 2010 at 11:30 am (EDT). PRA's senior vice president of Scientific and Medical Affairs, Kent Thoelke, will be the presenter.

16 Jul 2010

An overview of AAPM annual meeting

AAPM is the premier organization in medical physics, a broadly-based scientific and professional discipline encompassing physics principles and applications in medicine and biology. Its membership includes medical physicists who specialize in research that develops cutting-edge technologies and board-certified clinical medical physicists who apply these technologies in community hospitals, clinics, and academic medical centers.

16 Jul 2010

Joint statement to help patients, physicians make informed decisions about use of rosiglitazone

The Endocrine Society, American Diabetes Association and American Association of Clinical Endocrinologists issue joint statement in response to an FDA panel's recommendation to keep rosiglitazone (Avandia) on the market

16 Jul 2010

Medicine News and Research

Olig1 and Olig2 genes are associated with Down syndrome, scientists identify

Researchers to receive $1.2M from Susan G. Komen for the Cure for breast cancer research

New mechanism that drives development of B-lymphocytes in bone marrow discovered

Low-dose method of performing CT heart scans developed at Porter Adventist Hospital

FDA warns public over safety of stolen Advair Diskus inhalers

GABA disrupts working memory in neurofibromatosis type 1 patients

Report on current state of research in information security and privacy in healthcare

Cetuximab recommended for colorectal cancer tumors without mutation in KRAS gene

CCTP focuses on identifying, testing drugs for cancer stem cell treatment

AMPK may regulate epigenetic mechanism: Research

ICON opens purpose-built clinical pharmacology unit within CMFT campus

Ronald Reagan UCLA Medical Center ranks first: U.S. News & World Report survey

Hospitals fight for primary care docs as bad nurses allowed to continue work

FDA can promote personalized medicine by identying gaps in laboratory operations: ACLA

Research findings may help identify human TOR kinase inhibitors

Today's OpEds: Shift entitlement spending to the states; The lack of a GOP health plan; Battling tobacco

Recent releases in Global Health

Best practices for increasing clinical trial site and patient recruitment

An overview of AAPM annual meeting

Joint statement to help patients, physicians make informed decisions about use of rosiglitazone

Everything there is to know about biosimilars eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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