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Tips for fighting drug-resistant superbugs

Superbug CRKP is just the latest in emerging strains of drug-resistant bacteria. While new drugs to combat these stealthy microbes like MRSA and CRKP remain in development what can we do to prevent catching and spreading these dangerous bugs?.

13 May 2011

Gene manipulation can improve survival rates during sepsis infection

Sepsis is a major killer in hospital intensive care units. Researchers at Case Western Reserve University School of Medicine have found that manipulating a genetic factor that can launch or throttle the body's defenses can improve survival rates during bacterial infection.

13 May 2011

New computational model can analyze living cells, social networks

At first glance, a diagram of the complex network of genes that regulate cellular metabolism might seem hopelessly complex, and efforts to control such a system futile. However, an MIT researcher has come up with a new computational model that can analyze any type of complex network - biological, social or electronic - and reveal the critical points that can be used to control the entire system.

13 May 2011

New clinical data affirms safety profile of PolyMedix's PMX-30063 in treatment of Staph infections

PolyMedix, Inc., an emerging biotechnology company focused on developing new therapeutic drugs to treat life-threatening infectious diseases and acute cardiovascular disorders, presented new clinical and pre-clinical data related to the safety and efficacy of its novel, lead defensin-mimetic antibiotic, PMX-30063.

12 May 2011

CrystalGenomics receives draft CSR for CG400549 Phase I MAD study in Staph infections

CrystalGenomics, Inc., a biopharmaceutical company with 3 clinical stage candidates, has announced today that the draft Clinical Study Report from CG400549's Phase I Multiple Ascending Dose Study has just been received.

12 May 2011

Atox Bio completes AB103 phase 1 study in severe bacterial infections and sepsis

Atox Bio Inc. today announced that it successfully completed a phase 1 clinical study of AB103, a novel therapy for the treatment of severe bacterial infections and sepsis.

12 May 2011

Salmonella enterica bacterium activates virulence genes through Fur protein

Salmonella enterica, one of the main causes of gastrointestinal infections, modulates its virulence gene expression, adapting it to each stage of the infection process, depending on the free iron concentration found in the intestinal epithelium of its host.

12 May 2011

New research sheds light on common pathogenic mechanisms underlying Huntington's disease

New research sheds light on common pathogenic mechanisms shared by Huntington's disease (HD) and HD-like disorders. The study, published by Cell Press in the May 12, 2011, issue of the journal Neuron, uses a new transgenic mouse model for an HD-like disorder to unravel complex molecular events that drive disease pathology.

12 May 2011

Sugar boosts effectiveness of first-line antibiotics against chronic bacterial infections

James Collins, a pioneering researcher in the new field of systems biology and a MacArthur Genius, says: "You know the old saying: 'a spoonful of sugar makes the medicine go down?' This is more like 'a spoonful of sugar makes the medicine work.'

12 May 2011

Irritable Bowel Syndrome linked to bacterial overgrowth, food poisoning

Cedars-Sinai researchers have reported two advances in the understanding of Irritable Bowel Syndrome, the most common gastrointestinal disorder in the United States, affecting an estimated 30 million people.

12 May 2011

Liquid rice hull smoke could help fight diseases

Liquid smoke flavoring made from hickory and other wood - a mainstay flavoring and anti-bacterial agent for the prepared food industry and home kitchens - may get a competitor that seems to be packed with antioxidant, antiallergenic and anti-inflammatory substances, according to a new study in ACS' Journal of Agricultural and Food Chemistry. It is the first analysis of liquid smoke produced from rice hulls, the hard, inedible coverings of rice grains.

12 May 2011

Insight into probiotic bacteria can help improve intestinal disease treatments

The gut may need bacteria to provide a little bit of oxidative stress to stay healthy, new research suggests. Probiotic bacteria promote healing of the intestinal lining in mice by inducing the production of reactive oxygen species, researchers at Emory University School of Medicine have shown.

11 May 2011

Novel two-drug combination cures young patient with extensively drug-resistant tuberculosis

Belgian physicians report they have cured a young patient with extensively drug-resistant tuberculosis (XDR-TB) using a novel two-drug combination developed by researchers at Albert Einstein College of Medicine of Yeshiva University. The report, published in the Pediatric Infectious Disease Journal, marks the first known clinical use of this treatment for XDR-TB, the most deadly form of the disease.

11 May 2011

16-year-old uses supercomputing network to invent new drug cocktail for cystic fibrosis

While many 16-year-olds are content with PlayStation, Toronto-area student Marshall Zhang used the Canadian SCINET supercomputing network to invent a new drug cocktail which could one day help treat cystic fibrosis.

11 May 2011

Dalbavancin surveillance antibiotic results for Gram-positive pathogens presented at ECCMID meeting

Durata Therapeutics today announced surveillance data demonstrating potency of the Company's lead antibiotic product, dalbavancin, a long-acting, intravenous lipoglycopeptide, against a broad spectrum of gram-positive bacteria prevalent in recent years.

10 May 2011

Tetraphase presents TP-434, TP-2758 antibiotics study data against pathogens at ECCMID

Tetraphase Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company focused on next-generation antibiotics, announced today that it is presenting new results of several studies designed to support the continued advancement of its lead antibiotic, TP-434, a potent new broad-spectrum intravenous antibiotic with oral stepdown potential effective against difficult-to-treat and multidrug-resistant pathogens.

10 May 2011

Starpharma inks licence agreement in Japan with Okamoto for VivaGel-coated condoms

Starpharma Holdings Limited today announced that it has signed a licence agreement with Okamoto Industries Inc in relation to the VivaGel(r)-coated condom for the Japanese market. Okamoto is the market leader for condoms sold in Japan, the world's second largest condom market.

10 May 2011

Bacterial News and Research

Tips for fighting drug-resistant superbugs

Gene manipulation can improve survival rates during sepsis infection

New computational model can analyze living cells, social networks

New clinical data affirms safety profile of PolyMedix's PMX-30063 in treatment of Staph infections

CrystalGenomics receives draft CSR for CG400549 Phase I MAD study in Staph infections

Atox Bio completes AB103 phase 1 study in severe bacterial infections and sepsis

Salmonella enterica bacterium activates virulence genes through Fur protein

New research sheds light on common pathogenic mechanisms underlying Huntington's disease

Sugar boosts effectiveness of first-line antibiotics against chronic bacterial infections

Irritable Bowel Syndrome linked to bacterial overgrowth, food poisoning

Liquid rice hull smoke could help fight diseases

Insight into probiotic bacteria can help improve intestinal disease treatments

Novel two-drug combination cures young patient with extensively drug-resistant tuberculosis

16-year-old uses supercomputing network to invent new drug cocktail for cystic fibrosis

Dalbavancin surveillance antibiotic results for Gram-positive pathogens presented at ECCMID meeting

Tetraphase presents TP-434, TP-2758 antibiotics study data against pathogens at ECCMID

Starpharma inks licence agreement in Japan with Okamoto for VivaGel-coated condoms

Scientists to identify host bacteria that colonize different hybrids

Cempra to present solithromycin Phase 1 study data at ECCMID/ICC meeting

MicroPhage receives FDA clearance for KeyPath MRSA/MSSA Blood Culture Test

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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