Compound News and Research

RSS

Resverlogix receives FDA approval to start clinical trial for RVX-208

Resverlogix Corp. has announced that it has received approval by the US Food and Drug Administration (FDA) to initiate a Phase 1a clinical trial of oral RVX-208 in the USA. RVX-208 is a novel first-in-class small molecule that increases the production of ApoA-I and HDL.

10 Dec 2007

Safe and effective therapy discovered for patients with protein-losing enteropathy

Researchers at the Burnham Institute for Medical Research (Burnham Institute) have developed the first model to study intestinal protein leakage in mice, allowing the team to control and replicate both genetic deficiencies and environmental damages in an in vivo setting.

10 Dec 2007

Antibacterial chemical in bath soaps disrupts hormone activities

A new UC Davis study shows that a common antibacterial chemical added to bath soaps can alter hormonal activity in rats and in human cells in the laboratory - and does so by a previously unreported mechanism.

10 Dec 2007

Study questions impact of hemoglobin variations on mortality in dialysis patients

For patients with dialysis-related anemia, the risk of death is increased when hemoglobin levels remain persistently low over a period several months - not necessarily when they fluctuate over time, according to a study in the January Clinical Journal of the American Society of Nephrology.

5 Dec 2007

Hydrogen sulfide provides clues to a longer life

Hydrogen sulfide, or H2S, the chemical that gives rotten eggs their sulfurous stench - and the same compound that researchers at Fred Hutchinson Cancer Research Center successfully have used to put mice into a state of reversible metabolic hibernation - has now been shown to significantly increase life span and heat tolerance in the nematode worm, or C. elegans.

4 Dec 2007

Benzethonium chloride products identified as best for killing MRSA

One type of over-the-counter product for topical wound care is more effective than others in killing methicillin-resistant Staphylococcus aureus bacteria, or MRSA, which is potentially deadly and in recent years has moved from its historic hospital setting to a much broader public concern.

4 Dec 2007

Broccoli shows benefits for epidermolysis bullosa simplex

The compound sulforaphane whose natural precursors are found at high levels in broccoli and other cruciferous vegetables has been hailed for its chemopreventive powers against cancer.

3 Dec 2007

Bionovo describes a new class of therapeutic compounds

Bionovo, Inc. has announced the publication of a groundbreaking paper in the journal Molecular and Cellular Endocrinology covering the isolation, identification and description of a pure chemical compound, liquiritigenin, which represents a new class of therapeutic compounds showing promise for the safe treatment of menopausal symptoms.

2 Dec 2007

New anti-infective drug aims to fight drug-resistant bacteria at source

Deadly methicillin-resistant Staphylococcus aureus - MRSA - a bacterium that responds poorly to conventional antibiotic treatment, infects 90,000 Americans per year and causes 19,000 deaths, most in hospital settings.

29 Nov 2007

Effects of weight, genetics and religious beliefs on prostate cancer

African-American men face an observable disadvantage versus Caucasian men when it comes to prostate cancer survival.

29 Nov 2007

Cancer risks for urban African-American women grow, healthy diets more difficult to maintain

Women living in the inner city have difficulty meeting dietary goals that could help prevent cancer, according to a report from Johns Hopkins University researchers.

29 Nov 2007

Omega-3 fatty acids protect the brain against Parkinson's disease

Omega-3 fatty acids protect the brain against Parkinson's disease, according to a study by Université Laval researchers published in the online edition of the FASEB Journal, the journal of the Federation of American Societies for Experimental Biology.

27 Nov 2007

Adding water-soluble polymer to anti-cancer drug helps reach brain tumors

Bioengineers at Yale and Cornell have created a modified chemotherapy that more effectively reaches and remains at the site of brain tumors — by adding a water-soluble polymer to the anti-cancer drug, according to a report in the November-December issue of Bioconjugate Chemistry.

27 Nov 2007

New drug called nitrosyl-cobinamide could potentially be used to treat hypertension and heart disease

Investigators at the University of California, San Diego School of Medicine have developed a new drug called nitrosyl-cobinamide.

27 Nov 2007

There is a new twist on the question of how biological clocks work

In recent years, scientists have discovered that biological clocks help organize a dizzying array of biochemical processes in the body. Despite a number of hypotheses, exactly how the microscopic pacemakers in every cell in the body exert such a widespread influence has remained a mystery.

21 Nov 2007