Protein C News and Research

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Recombination most often occurs on the COVID-19 phylogenetic tree in the form of 'long branches'

An analysis of millions of SARS-CoV-2 genomes finds that recombination of the virus is uncommon, but when it occurs, it is most often in the spike protein region, the area which allows the virus to attach to and infect host cells.

11 Aug 2022

Assessment of replicon ribonucleic acid COVID-19 vaccine in nonhuman primates

Researchers explored the immunogenicity of a replicon ribonucleic acid (repRNA) COVID-19 vaccine, repRNA-CoV2S, in pigtail macaques.

11 Aug 2022

Crying out for new disease diagnoses

In this interview, we speak to Dr. Fei Liu and Dr. Luke P. Lee about their new iTears platform and how it could help to diagnose disease from tears.

11 Aug 2022

Gut microbial and immune parameters linked to heterogeneous inter-personal COVID-19 vaccine-triggered immunity

A new study identified the gut microbial and immune variables linked to heterogeneous messenger ribonucleic acid (mRNA) COVID-19 vaccine responses between individuals.

11 Aug 2022

SARS-CoV-2 receptor-binding domain-based protein subunit vaccine shows promise against multiple SARS-CoV-2 variants

Researchers described a novel protein subunit vaccine comprising the receptor-binding domain (RBD) of ancestral SARS-CoV-2 spike (S) protein, dimerized with an immunoglobulin (Ig)G1-fraction, crystallizable (Fc) domain.

11 Aug 2022

$Women on vegetarian diet have higher risk of hip fracture compared to regular meat-eaters$

Women on vegetarian diet have higher risk of hip fracture compared to regular meat-eaters

A study of over 26,000 middle-aged UK women reveals those with a vegetarian diet had a 33% higher risk of hip fracture compared to regular meat-eaters.

11 Aug 2022

Nanoparticle-based lateral flow immunoassay for the detection of anti-SARS-CoV-2 neutralizing antibodies

In a recent Biomaterials study, researchers developed AIEgen-embedded polystyrene (PS) nanoparticles-based LFIA that can accurately detect anti-SARS-CoV-2 NAb in serum samples of vaccinated individuals.

11 Aug 2022

Scientists develop nanoantidote to reduce acidosis in critically ill COVID-19 patients

A group of scientists from China has recently developed an antacid nanoantidote that can effectively ameliorate blood acidosis induced by SARS-CoV-2 infection.

11 Aug 2022

UIC focuses on developing an antiviral therapy for filoviruses

Researchers at the University of Illinois Chicago are working with the National Institutes of Health and researchers from across the country to establish a center for antiviral drug development for pandemic-level viruses, including Ebola and SARS-CoV-2, the virus that causes COVID-19.

11 Aug 2022

Interferon beta reduces binding of three components to RBCs, study finds

Drugs called interferon betas are common treatments for multiple sclerosis (MS), reducing relapses and slowing motor function decline. Interferon beta, a protein known to contain a zinc binding pocket, is thought to reduce proinflammatory molecules and even increase production of anti-inflammatory species in MS patients.

11 Aug 2022

Study quantifies the prognostic accuracy of two protein biomarkers

Blood tests taken within 24 hours of a traumatic brain injury (TBI) flag which patients are likely to die and which patients are likely to survive with severe disability, according to a study headed by UC San Francisco, the University of Pennsylvania and the University of Michigan. Their results -- available within minutes -- may confirm the need for prompt surgical interventions or may help guide conversations with families in cases of devastating injury.

11 Aug 2022

New computation-guided approach to identify small molecule corrector drugs for p53 hotspot mutations

A new study, led by researchers from the University of California, Irvine and the University of California, San Diego, reveals a new computation-guided approach to identify small molecules that can restore aspects of wild-type p53 tumor suppression function to mutated p53, which play an important role in many human cancers.

11 Aug 2022

A low-energy, high FODMAP diet in prediabetes and diabetes?

Researchers summarize the available knowledge on FODMAPs and suggest that they can play a role in the prevention and treatment of diabetes.

10 Aug 2022

Research may lead the way to a simpler treatment for cancer

Sometimes too much of a good thing is not good at all. Inhibiting the function of the PD-1 protein, which blocks immune function, has shown high therapeutic efficacy in cancer immunotherapy.

10 Aug 2022

UTSW scientists discover mechanism of RNA capping by SARS-CoV-2 virus

A team led by UT Southwestern researchers has identified how SARS-CoV-2, the virus that causes COVID-19, builds a structure called the RNA cap that's critical for successful viral replication.

10 Aug 2022

Blood-based biomarkers can accurately predict a patient's risk of death or disability after TBI

A study funded by the National Institutes of Health found that biomarkers present in the blood on the day of a traumatic brain injury (TBI) can accurately predict a patient's risk of death or severe disability six months later.

10 Aug 2022

Research identifies unique vulnerabilities in ALT cancers that can serve as novel therapeutic targets

In a study recently published in Cancer Research, a journal of the American Association for Cancer Research, a team of researchers led by C. Patrick Reynolds, M.D., Ph.D., director for the Texas Tech University Health Sciences Center School of Medicine Cancer Center, sought to expand upon his lab's previous research that showed ALT tumors identified by a biomarker known as C-circles share a common biology that confers vulnerabilities to be exploited for cancer therapy.

10 Aug 2022

Protein C News and Research

Recombination most often occurs on the COVID-19 phylogenetic tree in the form of 'long branches'

Assessment of replicon ribonucleic acid COVID-19 vaccine in nonhuman primates

Crying out for new disease diagnoses

Gut microbial and immune parameters linked to heterogeneous inter-personal COVID-19 vaccine-triggered immunity

SARS-CoV-2 receptor-binding domain-based protein subunit vaccine shows promise against multiple SARS-CoV-2 variants

Women on vegetarian diet have higher risk of hip fracture compared to regular meat-eaters

Nanoparticle-based lateral flow immunoassay for the detection of anti-SARS-CoV-2 neutralizing antibodies

Scientists develop nanoantidote to reduce acidosis in critically ill COVID-19 patients

UIC focuses on developing an antiviral therapy for filoviruses

Interferon beta reduces binding of three components to RBCs, study finds

Study quantifies the prognostic accuracy of two protein biomarkers

New computation-guided approach to identify small molecule corrector drugs for p53 hotspot mutations

A low-energy, high FODMAP diet in prediabetes and diabetes?

Research may lead the way to a simpler treatment for cancer

UTSW scientists discover mechanism of RNA capping by SARS-CoV-2 virus

Blood-based biomarkers can accurately predict a patient's risk of death or disability after TBI

Research identifies unique vulnerabilities in ALT cancers that can serve as novel therapeutic targets

Review of natural products with promising anti-SARS-CoV-2 potential

Scientists conduct comparative analysis of monkeypox virus profilin-like proteins and human profilin proteins

Experimental drug protects mice from sudden death due to blood vessel rupture

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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