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Phase–amplitude coupling changes may underlie DBS success in parkinsonism

Deep-brain stimulation of the subthalamic nucleus may improve motor symptoms in patients with Parkinson’s disease by reducing excessive cortical phase–amplitude coupling, researchers report in Nature Neuroscience.

14 Apr 2015

Latest findings regarding nitric oxide offer new avenues to save lives

Professor Jonathan Stamler's latest findings regarding nitric oxide have the potential to reshape fundamentally the way we think about the respiratory system - and offer new avenues to save lives. It may be time to rewrite the textbooks.

13 Apr 2015

MEMREHAB trial shows that treatment with mSMT may be adversely affected by cognitive dysfunction

Kessler Foundation researchers published a subanalysis of their MEMREHAB trial, which shows that treatment with the modified Story Memory Technique (mSMT) may be affected by cognitive dysfunction. Investigators looked at the influence of processing speed on benefits of the mSMT, a 10-session cognitive intervention protocol shown to improve new learning and memory in individuals with MS.

13 Apr 2015

Study may help find treatments for nerve cell damage, neurodegenerative disorders

Scientists from Kyoto University's Institute for Integrated Cell-Material Sciences in Japan have have discovered how nerve cells adjust to low energy environments during the brain's growth process.

13 Apr 2015

Eisai, Arena complete two Phase 1 registrational trials for once-daily formulation of lorcaserin

Eisai Inc. and Arena Pharmaceuticals, Inc. today announced the completion of two Phase 1 registrational clinical trials that Eisai and Arena believe demonstrate bioequivalence of an investigational once-daily extended release formulation of lorcaserin, as compared to the twice-daily immediate release formulation approved by the US Food and Drug Administration and marketed as BELVIQ.

13 Apr 2015

Vascular mimicry can spread breast cancer to other sites

Imitation may be the sincerest form of flattery, but it can also have deadly consequences, at least when it comes to tumor cells.

10 Apr 2015

Mental practice, physical therapy effective for stroke survivors

A combination of mental practice and physical therapy is an effective treatment for people recovering from a stroke, according to researchers at Georgia State University.

9 Apr 2015

Arts and craft activities, computer use may stave off memory problems

People who participate in arts and craft activities and who socialize in middle and old age may delay the development in very old age of the thinking and memory problems that often lead to dementia, according to a new study published in the April 8, 2015, online issue of Neurology, the medical journal of the American Academy of Neurology.

9 Apr 2015

Phase 2 IMAGO trial of SHP625 fails to meet primary endpoints in pediatric patients with ALGS

Shire plc today announced that the 13-week Phase 2 IMAGO trial of its investigational compound SHP625 (LUM001) did not meet the primary or secondary endpoints in the study of 20 pediatric patients with Alagille syndrome (ALGS), a rare, life-threatening genetic disorder that presents with chronic cholestasis (accumulation of bile acids in the liver) and severe pruritus (itching).

9 Apr 2015

Understanding emotional processing deficit

Kessler Foundation researchers have linked the inability to recognize facial affect (emotion) with white matter damage after traumatic brain injury (TBI), an important first step toward understanding this emotional processing deficit. Their findings indicate a pattern of white matter damage and gray matter atrophy associated with this specific impairment of social cognition after TBI.

9 Apr 2015

Johns Hopkins neurosurgeon awarded Cortes de Cadiz Prize by the city council of Cadiz, Spain

Johns Hopkins neurosurgeon Alfredo Quinones-Hinojosa has been awarded the Cortes de Cadiz Prize in the category of surgery by the city council of Cadiz, Spain. The jury prize, in which members of the Royal Academy of Medicine and Surgery took part, was awarded to Quinones-Hinojosa not only for his renowned scientific career but also for his “moving life experience,” which, the judges noted, is full of “self-improvement and success.”

9 Apr 2015

New simeprevir clinical data to be presented at EASL's International Liver Congress 2015

Janssen Sciences Ireland UC, one of the Janssen Pharmaceutical Companies of Johnson & Johnson, today announced that clinical data for simeprevir, its NS3/4A protease inhibitor for the treatment of hepatitis C virus (HCV) infection, will be presented at The International Liver Congress 2015 of the European Association for the Study of the Liver taking place in Vienna from April 22-26.

8 Apr 2015

Scientists identify brain molecule that triggers schizophrenia-like behaviors, brain changes

Scientists at The Scripps Research Institute have identified a molecule in the brain that triggers schizophrenia-like behaviors, brain changes and global gene expression in an animal model. The research gives scientists new tools for someday preventing or treating psychiatric disorders such as schizophrenia, bipolar disorder and autism.

8 Apr 2015

New study could point to potential ways to address defects in learning, memory

Just as some people seem built to run marathons and have an easier time going for miles without tiring, others are born with a knack for memorizing things, from times tables to trivia facts. These two skills—running and memorizing—are not so different as it turns out.

8 Apr 2015

Brain's primary visual cortex can drive the timing of actions

When managing, assigning each task to a specialist is often the most efficient strategy. Most researchers regard the brain as working similarly, with each region specialized to a given task. But Johns Hopkins neuroscientists have found, in rats, that the brain's primary visual cortex (VC) not only portrays the visual world but can also drive the timing of actions.

8 Apr 2015

Study: Broken communication in brain regions appears to worsen Huntington's disease

Indiana University researchers have found that broken communication in a specific part of the brain plays a role in the involuntary physical movements that affect individuals with Huntington's disease.

7 Apr 2015

Findings of Ariosa's non-invasive prenatal testing study published online in NEJM

Results from the largest clinical trial to date, comparing non-invasive prenatal testing (NIPT) using the Harmony Prenatal Test with conventional first trimester combined screening (FTS) in a general pregnancy population have been published online in The New England Journal of Medicine.

6 Apr 2015

Study reveals how cell's protein quality control mechanism helps combat neurodegenerative diseases

A molecular pathway known to suppress tumors appears to also be a major player in clearing cells of damaged proteins implicated in neurodegenerative diseases such as ALS and certain types of dementia, new research in roundworms and human cells suggests.

6 Apr 2015

Sanford-Burnham, Daiichi Sankyo sign licensing agreement to expand development of small molecule

Sanford-Burnham Medical Research Institute today announced that it has signed a licensing agreement to further develop a first-in-class small molecule with Daiichi Sankyo for the treatment of cardiovascular-metabolic disease.

6 Apr 2015

Astellas Pharma, MD Anderson sign option agreement to research and develop new treatment for AML

Astellas Pharma Inc. and The University of Texas MD Anderson Cancer Center today announced the signing of an option agreement to research and develop a new treatment for patients with acute myeloid leukemia (AML).

6 Apr 2015

Neuroscience News and Research

Phase–amplitude coupling changes may underlie DBS success in parkinsonism

Latest findings regarding nitric oxide offer new avenues to save lives

MEMREHAB trial shows that treatment with mSMT may be adversely affected by cognitive dysfunction

Study may help find treatments for nerve cell damage, neurodegenerative disorders

Eisai, Arena complete two Phase 1 registrational trials for once-daily formulation of lorcaserin

Vascular mimicry can spread breast cancer to other sites

Mental practice, physical therapy effective for stroke survivors

Arts and craft activities, computer use may stave off memory problems

Phase 2 IMAGO trial of SHP625 fails to meet primary endpoints in pediatric patients with ALGS

Understanding emotional processing deficit

Johns Hopkins neurosurgeon awarded Cortes de Cadiz Prize by the city council of Cadiz, Spain

New simeprevir clinical data to be presented at EASL's International Liver Congress 2015

Scientists identify brain molecule that triggers schizophrenia-like behaviors, brain changes

New study could point to potential ways to address defects in learning, memory

Brain's primary visual cortex can drive the timing of actions

Study: Broken communication in brain regions appears to worsen Huntington's disease

Findings of Ariosa's non-invasive prenatal testing study published online in NEJM

Study reveals how cell's protein quality control mechanism helps combat neurodegenerative diseases

Sanford-Burnham, Daiichi Sankyo sign licensing agreement to expand development of small molecule

Astellas Pharma, MD Anderson sign option agreement to research and develop new treatment for AML

Event guide: 8th Neuroimmunology Drug Development Summit 2026 eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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