Receptor News and Research

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Diabetes-related proteins seen in high-res for the first time

A team of researchers have reported, in an exciting study published in the journal Nature Communications, that they were able to examine an important receptor at high definition for the first time. This detailed visualization has helped them greatly to understand its mechanism of functioning. This could help develop better ways to treat Type 2 diabetes mellitus as well as other conditions.

23 Jan 2020

New Distinguished Scholar Award aims to mitigate gender gaps in medical research

The Icahn School of Medicine at Mount Sinai - an international leader in medical and scientific training, biomedical research, and patient care - today announced the recipients of the first-of-its-kind Distinguished Scholar Award, a new annual grant sponsored by the Office of Gender Equity in Science and Medicine. The awards aim to mitigate gender gaps in medical research by supporting researchers with additional project resources while they serve as family caretakers.

23 Jan 2020

Researchers identify novel cellular entry factor for AAV vector types

Researchers led by a team at Massachusetts Eye and Ear have identified a novel cellular entry factor for adeno-associated virus vector (AAV) types--the most commonly used viral vectors for in vivo gene therapy. AAVs are vectors-or vehicles--that are created from a virus that is made harmless by molecular engineering, and have shown promise transporting genetic therapy treatments to affected tissues.

23 Jan 2020

GW expands clinical trial of neoadjuvant immunotherapy for high-risk cutaneous squamous cell carcinoma

The Cutaneous Oncology Program at the George Washington University (GW) Cancer Center was selected as the first global site for a clinical trial for patients with high-risk cutaneous squamous cell carcinoma.

22 Jan 2020

Study finds stress does whiten hair

In most cases, hair starts to gray in the thirties, and becomes pronounced in the fifties, at which time the head is typically crowned with a thatch of white, gray and perhaps some hair of the original color. A new study published January 2020 in the journal Nature, shows that this process is speeded up significantly by acute stress persisting over a period, or by severe trauma.

22 Jan 2020

Study provides key insights on potential origins of coronavirus outbreak in China

Emerging viral infections--from bird flu to Ebola to Zika infections--pose major threats to global public health, and understanding their origins can help investigators design defensive strategies against future outbreaks.

22 Jan 2020

New chemical compound can enable more precise analysis of NMDAR activity

NMDARs (N-methyl-D-aspartate receptors) serve as valves on nerve cells, controlling the flow of electrical signals in the brain.

22 Jan 2020

Persistant industrial chemical modifies gut microbiome of mice

An industrial chemical -- phased out since 2002, but previously used in stain and water-repellent products and firefighting foam -- alters the gut microbiome of mice and could have implications for human health, according to an international team of researchers.

21 Jan 2020

Powerful combination of experimental drugs reverses osteoarthritis in rats

People with osteoarthritis, or "wear and tear" arthritis, have limited treatment options: pain relievers or joint replacement surgery.

21 Jan 2020

Discovery of potent immune cell that can destroy multiple types of cancer

The immune system is the body’s defense against harmful pathogens that may enter the body. Immune cells, such as white blood cells and macrophages work hand in hand to fight off disease-causing microorganisms, including cancer.

21 Jan 2020

Drug profiling and gene editing method open new avenues in the development of CAR T-cell therapy

Researchers have discovered ways to boost CAR T-cell therapy.

21 Jan 2020

Biophysicists shed light on the structure, functioning mechanism of CysLT receptors

Biophysicists from the MIPT Center for Molecular Mechanisms of Aging and Age-Related Diseases have teamed up with colleagues from Canada, the U.S., Japan, France, and Germany to shed light on the structure and functioning mechanism of the CysLT receptors, which regulate inflammatory responses associated with allergic disorders.

21 Jan 2020

Discovery of new killer T-cell offers hope of a 'one-size-fits-all' cancer therapy

Researchers at Cardiff University have discovered a new type of killer T-cell that offers hope of a "one-size-fits-all" cancer therapy.

21 Jan 2020

Study finds new strategies for developing cancer drug

After years of research on cell surface receptors called Frizzleds, researchers at Karolinska Institutet in Sweden provide the proof-of-principle that these receptors are druggable by small molecules. The results, which are published in the scientific journal Nature Communications, open for new strategies to treat different types of cancer.

21 Jan 2020