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Microgel-coated mesenchymal stromal cells can reverse pulmonary fibrosis

Researchers at the University of Illinois Chicago have shown that even after lung tissue has been damaged, it may be possible to reverse fibrosis and promote tissue repair through treatment with microgel-coated mesenchymal stromal cells.

9 Jun 2021

International coalition develops classification criteria for 25 subtypes of uveitis

An international coalition of eye researchers used machine learning to develop classification criteria for 25 of the most common types of uveitis, a collection of over 30 diseases characterized by inflammation inside the eye.

7 Jun 2021

High baseline levels of inflammatory cytokines linked to thrombotic events in patients with COVID-19

In a recent open-access paper published in the Journal of Clinical Medicine, researchers from Iran and Germany show that high baseline levels of inflammatory cytokines measured during admission put patients with coronavirus disease (COVID-19) at increased risk of developing coagulopathy, thrombotic events – and even death.

6 Jun 2021

Metformin potently inhibits SARS-CoV-2-induced cytokine release in monocytes

An interesting new bioRxiv* preprint reports the suppression of monocyte glycolysis and cytokine production when exposed to the virus, following pretreatment with the commonly used drug, metformin.

6 Jun 2021

Maternal SARS-CoV-2 infection imprints immune response in the newborn

A new bioRxiv* preprint reports the immunological footprint in the newborn left by maternal infection with SARS-CoV-2 during pregnancy.

4 Jun 2021

E484K mutation may confer immune evasion capability on UK variant of SARS-CoV-2

A new medRxiv* preprint reports the immunomodulatory effect of the E484K mutation newly acquired by the United Kingdom (U.K.) variant.

2 Jun 2021

Large-scale expansion of spike-reactive T cells feasible after COVID-19 vaccination

A new bioRxiv* preprint reports on the successful use of a protocol to expand SARS-CoV-2-reactive T-cells a thousand-fold.

2 Jun 2021

Study identifies protein that could be the key to improving heart attack treatment outcomes

A new study led by researchers at Washington State University has identified a protein that could be the key to improving treatment outcomes after a heart attack.

2 Jun 2021

Can depression increase the likelihood of rapid kidney function decline?

In a recent study, the presence of depressive symptoms in normally healthy individuals was found to correlate with rapid kidney function decline.

1 Jun 2021

Inflammatory brain injury higher in men with acute COVID-19, finds study

The COVID-19 pandemic has been associated with both short- and long-term neurologic complications, including stroke, brain fog and persistent tiredness. A new study concludes that the effects of SARS-CoV-2 on the central nervous system (CNS) are due to the endothelial injury and inflammation that this produces in the brain.

31 May 2021

Researchers assess the prognostic value of cardiac troponin I in COVID-19 patients

Corona Virus Disease (COVID -19) patients primarily appear with respiratory issues and viral pneumonia. The patients may also present cardiovascular issues includes early signs of acute myocardial injury.

29 May 2021

Early use of biologics is recommended for patients with luminal and fistulizing Crohn's disease

Crohn's disease, a type of inflammatory bowel disease (IBD) that causes inflammation (pain and swelling) in the gastrointestinal tract, can cause daily health problems, frequent hospitalizations and surgery when not adequately controlled.

28 May 2021

Vagus nerve stimulation may be a potential adjunct therapy for COVID-19

COVID-19 was initially described as lung inflammation, or pneumonia, in older adults. However, we now know that SARS-CoV-2 infections can cause a wide range of symptoms in people of all ages, ranging from no symptoms at all to systemic inflammation and even death.

27 May 2021

Research suggests Garcinia kola extract might suppress severe COVID-19 cytokine storms

Researchers in the UK and Nigeria have conducted a study showing that Garcinia kola seed extract and garcinoic acid may provide therapeutic benefits in the late stage of severe coronavirus disease 2019 (COVID-19) and other coronavirus infections.

24 May 2021

Facets of SARS-CoV-2 infection and animal models

A new study in the journal Frontiers in Cell and Developmental Biology discusses the ribonucleic acid (RNA) genome of the virus, and the mechanisms by which it establishes infection within the host cell. The researchers also summarize the development of animal models of COVID-19, which will both help understand the clinical features of the illness, and indicate new approaches for the treatment of the infection.

21 May 2021

Toll-like receptor 2 (TLR2) detects the SARS-CoV-2 envelope protein and generates inflammatory cytokines

Researchers at St Jude Children’s Research Hospital found that toll-like receptor 2 detects the SARS-CoV-2 envelope protein-producing inflammatory cytokines.

19 May 2021

New data suggests fivefold increase in young children swallowing magnets over past 5 years in UK

There’s been a fivefold rise in the number of young children requiring treatment after having swallowed a magnet over the past 5 years in the UK, suggests data from specialist doctors in a letter published online in the Archives of Disease in Childhood.

17 May 2021

Black fungus complicates India's COVID pandemic

India faces a global health crisis as the number of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections reaches over 23.7 million. As India's health system buckles with increased admissions and a lack of resources, another health threat has emerged.

13 May 2021

Comprehensive blood atlas of COVID-19 identifies hallmarks of disease severity

Researchers in the UK have presented a multi-omics integrated blood atlas that delineates the host immune response in patients with coronavirus disease 2019 (COVID-19) of varying severity, providing a unique reference resource for the interpretation of datasets generated from interventional trials.

13 May 2021

Study reveals acute immunologic changes in children with long COVID

Many reports are beginning to emerge on the ‘long COVID’ phenomenon. But a new study, released as a preprint on the medRxiv* server, describes, for the first time, immunologic changes observed in children with PASC.

11 May 2021

Necrosis News and Research

Microgel-coated mesenchymal stromal cells can reverse pulmonary fibrosis

International coalition develops classification criteria for 25 subtypes of uveitis

High baseline levels of inflammatory cytokines linked to thrombotic events in patients with COVID-19

Metformin potently inhibits SARS-CoV-2-induced cytokine release in monocytes

Maternal SARS-CoV-2 infection imprints immune response in the newborn

E484K mutation may confer immune evasion capability on UK variant of SARS-CoV-2

Large-scale expansion of spike-reactive T cells feasible after COVID-19 vaccination

Study identifies protein that could be the key to improving heart attack treatment outcomes

Can depression increase the likelihood of rapid kidney function decline?

Inflammatory brain injury higher in men with acute COVID-19, finds study

Researchers assess the prognostic value of cardiac troponin I in COVID-19 patients

Early use of biologics is recommended for patients with luminal and fistulizing Crohn's disease

Vagus nerve stimulation may be a potential adjunct therapy for COVID-19

Research suggests Garcinia kola extract might suppress severe COVID-19 cytokine storms

Facets of SARS-CoV-2 infection and animal models

Toll-like receptor 2 (TLR2) detects the SARS-CoV-2 envelope protein and generates inflammatory cytokines

New data suggests fivefold increase in young children swallowing magnets over past 5 years in UK

Black fungus complicates India's COVID pandemic

Comprehensive blood atlas of COVID-19 identifies hallmarks of disease severity

Study reveals acute immunologic changes in children with long COVID

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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