Omicron News and Research

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Researchers report the first RT-qPCR for simultaneous detection and discrimination of Omicron sub-variants

Researchers developed a RT-qPCR system to identify SARS-CoV-2 Omicron variants of concern.

12 Oct 2022

Observational study explores the real-world efficacy of oral antivirals against the SARS-CoV-2 Omicron variant

A new study reported the real-world efficacy of oral antiviral therapies nirmatrelvir plus ritonavir, and molnupiravir on the SARS-CoV-2 Omicron (B.1.1.529) variant, based on an observational study among coronavirus disease 2019 (COVID-19) patients in Hong Kong.

12 Oct 2022

Molnupiravir and nirmatrelvir-ritonavir treatments are effective in reducing mortality among high-risk COVID-19 patients

A recent study determines the relationship between molnupiravir and nirmatrelvir-ritonavir and all-cause mortality.

12 Oct 2022

What is the effect of COVID-19 vaccination in pregnant and postpartum women infected with different SARS-CoV-2 variants?

Researchers discuss the impact of vaccination against SARS-CoV-2 on infection rates and severity in pregnancy and postpartum.

12 Oct 2022

What is the association of SARS-CoV-2 vaccination with the risk of PASC in patients with SARDs?

Findings of a new study depicted that fully vaccinated patients suffering from systemic autoimmune rheumatic diseases harbor a lower propensity to developing long COVID symptoms compared to SARDs patients who are not fully vaccinated.

11 Oct 2022

BNT162b2 COVID-19 booster vaccine induces robust humoral responses independent of the interval between the first two doses

A recent Cell Reports study evaluated humoral responses induced after the second and third doses of the mRNA vaccine.

11 Oct 2022

RNA-dependent RNA polymerase inhibitors in COVID-19 therapy

A new paper reviews current knowledge of RdRp inhibitors that could be developed further to provide broadly effective antivirals against SARS-CoV-2 in particular and CoVs in general.

10 Oct 2022

Researchers explore COVID-19 test-and-treat model computation with orally administered antiviral agents

In a new study, researchers used an oral antiviral agent-based severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test- and- treat (TT) model for coronavirus disease 2019 (COVID-19) mitigation in low-income countries (LICs).

10 Oct 2022

Evaluating graphene field effect biosensor for ultraprecise and simultaneous influenza and SARS-CoV-2 detection

In a new study, researchers developed an antibody (Ab)-modified graphene field effect transistor (GFET)-based biosensor for ultraprecise and rapid influenza A virus (IAV) and SARS-CoV-2 protein detection and differentiation.

10 Oct 2022

Effect of COVID-19 mRNA vaccination on COVID-19 severity during Omicron BA.4 and BA.5 predominance periods

In a new study, researchers estimated the association of first-generation messenger ribonucleic acid (mRNA) vaccines (BNT162b2, mRNA-1273) with coronavirus disease 2019 (COVID-19)-related medical encounters.

10 Oct 2022

UMSOM researchers identify how multiple genes of SARS-CoV-2 affect disease severity

University of Maryland School of Medicine researchers have identified how multiple genes of SARS-CoV-2 affect disease severity, which could lead to new ways in how we develop future vaccines or develop newer treatments.

7 Oct 2022

Neonatal mice-based model established that allows for the transmission of clinical SARS-CoV-2 isolates

Researchers established a neonatal mice model that enabled SARS-CoV-2 transmission.

7 Oct 2022

The magnitude and duration of the protective effect of prior infection and hybrid immunity against Omicron infection and severe disease

Researchers reviewed the duration and magnitude of the protective effect of previous SARS-CoV-2 infections and hybrid immunity against SARS-CoV-2 Omicron variant of concern infections and COVID-19 severity.

7 Oct 2022

Study using human and animal-derived cell lines suggests human origin of SARS-CoV-2 Omicron variant

Researchers examined the replicative capacity of seven SARS-CoV-2 isolates in 17 cell lines to understand their phenotypic variations and host range.

7 Oct 2022

Vaccine-induced neutralizing and non-neutralizing antibody activity against SARS-CoV-2

A new study demonstrated that vaccine-induced antibody functions against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diminish with age.

7 Oct 2022

Study suggests an immunological benefit of combining previous natural infection with vaccination against COVID-19 using a combination of different vaccine platforms

Researchers explored SARS-CoV-2-targeted immune responses among COVAC1 participants who received a novel saRNA vaccine followed by the mRNA BNT162b2 vaccine BNT162b2 vaccine, with or without prior COVID-19 history.

7 Oct 2022

mRNA boost offers better protection against COVID-19 in people who received two Coronavac doses

One year after mass vaccination against COVID-19 was launched, inactivated virus vaccines accounted for half of the doses administered worldwide.

6 Oct 2022

Study reports low incidence of severe COVID-19 among vaccinated and boosted individuals

A large study of COVID-19 disease following vaccination and booster, published in the Journal of the American Medical Association (JAMA), reports surprisingly low incidence, especially in individuals younger than 65 years of age with no high-risk conditions.

6 Oct 2022

Clinical trials of novel COVID-19 vaccine developed in Brazil to begin soon

Testing on humans of a novel COVID-19 vaccine developed in Brazil will begin this year. It performed well in animal trials, as reported in an article published in August in Nature Communications.

6 Oct 2022

Impaired immune responses not responsible for COVID-19 rebound, findings suggest

Findings from a small study of eight patients published in Clinical Infectious Diseases suggest that COVID-19 rebound is likely not caused by impaired immune responses.

6 Oct 2022

Omicron News and Research

Researchers report the first RT-qPCR for simultaneous detection and discrimination of Omicron sub-variants

Observational study explores the real-world efficacy of oral antivirals against the SARS-CoV-2 Omicron variant

Molnupiravir and nirmatrelvir-ritonavir treatments are effective in reducing mortality among high-risk COVID-19 patients

What is the effect of COVID-19 vaccination in pregnant and postpartum women infected with different SARS-CoV-2 variants?

What is the association of SARS-CoV-2 vaccination with the risk of PASC in patients with SARDs?

BNT162b2 COVID-19 booster vaccine induces robust humoral responses independent of the interval between the first two doses

RNA-dependent RNA polymerase inhibitors in COVID-19 therapy

Researchers explore COVID-19 test-and-treat model computation with orally administered antiviral agents

Evaluating graphene field effect biosensor for ultraprecise and simultaneous influenza and SARS-CoV-2 detection

Effect of COVID-19 mRNA vaccination on COVID-19 severity during Omicron BA.4 and BA.5 predominance periods

UMSOM researchers identify how multiple genes of SARS-CoV-2 affect disease severity

Neonatal mice-based model established that allows for the transmission of clinical SARS-CoV-2 isolates

The magnitude and duration of the protective effect of prior infection and hybrid immunity against Omicron infection and severe disease

Study using human and animal-derived cell lines suggests human origin of SARS-CoV-2 Omicron variant

Vaccine-induced neutralizing and non-neutralizing antibody activity against SARS-CoV-2

Study suggests an immunological benefit of combining previous natural infection with vaccination against COVID-19 using a combination of different vaccine platforms

mRNA boost offers better protection against COVID-19 in people who received two Coronavac doses

Study reports low incidence of severe COVID-19 among vaccinated and boosted individuals

Clinical trials of novel COVID-19 vaccine developed in Brazil to begin soon

Impaired immune responses not responsible for COVID-19 rebound, findings suggest

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