Protein C News and Research

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Boosting vitamin D in individuals with deficiencies likely to reduce chronic inflammation

Inflammation is an essential part of the body's healing process. But when it persists, it can contribute to a wide range of complex diseases including type 2 diabetes, heart disease, and autoimmune diseases.

8 Aug 2022

Optically controlled local heat-pulse method manipulates temperature in cells

A team of researchers led by Osaka University finds that mutant variants of the calcium channel protein RyR1 are hypersensitive to heat, which creates a positive feedback loop of calcium release and leads to malignant hyperthermia

8 Aug 2022

NIH researchers develop three-dimensional structure of twinkle protein

Researchers from the National Institutes of Health have developed a three-dimensional structure that allows them to see how and where disease mutations on the twinkle protein can lead to mitochondrial diseases.

5 Aug 2022

Researchers develop new method for visualizing single cell protein secretion with stunning resolution

We have recently witnessed the stunning images of distant galaxies revealed by the James Webb telescope, which were previously visible only as blurry spots.

5 Aug 2022

Researchers delve deeper into the structure of protein receptor crucial for cardiovascular health

5 Aug 2022

Vitamin B12, folic acid supplements could potentially halt or reverse advanced form of fatty liver disease

Scientists at Duke-NUS Medical School in Singapore have uncovered a mechanism that leads to an advanced form of fatty liver disease - and it turns out that vitamin B12 and folic acid supplements could reverse this process.

5 Aug 2022

New method can modify an entire substance class of medically relevant natural products

The use of the element fluorine to modify active substances is an important tool in modern drug development.

5 Aug 2022

Researchers analyze the genetic differentiation, diversity of Omicron variant during its early spread

More mutations have been carried by the SARS-CoV-2 Omicron variant than previously reported variants. However, the genetic differentiation and diversity within Omicron variant that occurs during its early spread remains unclear.

5 Aug 2022

Gut microbiota-derived metabolites offer protection against SARS-CoV-2

A new study investigated how the gut microbiome confers immunity to mammalian hosts against SARS-CoV-2 intranasal infection by generating short-chain fatty acids.

5 Aug 2022

Study identifies broad-spectrum antibody that neutralizes SARS-CoV-2 variants of concern

Scientists have described the identification and therapeutic evaluation of an antibody that broadly neutralizes major variants of SARS-CoV-2, including the alpha, beta, delta, and omicron variants.

5 Aug 2022

Researchers identify mechanistic principles for engineering antibodies to enhance cadherin adhesion

Future treatments for advanced cancer could work by sticking cancer cells in place and preventing their spread around the body. A new study by researchers at the University of California, Davis, and the University of Washington shows how an antibody strengthens bonds between cells. The work is published Aug. 3 in Proceedings of the National Academy of Sciences.

5 Aug 2022

Extracellular vesicle-based surface protein assay likely to lead to a better way to detect early-stage hepatocellular carcinoma

Primary liver cancer, the third-leading cause of cancer-related death worldwide, takes more than 30,000 lives in the United States each year. The high mortality rates can be attributed in part to the fact that a significant portion of the patients are detected at a late stage, when potentially curative treatments are no longer an option. Unfortunately, today's screening methods are not able to routinely provide accurate, early detection.

5 Aug 2022

Eating fish and seafood reduces risk of rheumatoid arthritis

Scientists determine the relationship between meat consumption and rheumatoid arthritis.

4 Aug 2022

Discovery could prevent insulin resistance and have significant benefits for people with type 2 diabetes

In a potential game changer for patients with type 2 diabetes, a team of researchers at the Diabetes, Obesity, and Metabolism Institute (DOMI) at the Icahn School of Medicine at Mount Sinai has identified a therapeutic target for the preservation and regeneration of beta cells (β cells) - cells in the pancreas that produce and distribute insulin.

4 Aug 2022

Individual genetic defects lead to heart failure in different ways, consortium reports

Cardiomyopathy is not a uniform disease. Rather, individual genetic defects lead to heart failure in different ways, an international consortium reports in Science.

4 Aug 2022

Researchers discover two signaling pathways that are downregulated in human hearts after birth

Published today in Stem Cell Reports, researchers from the University of Minnesota Medical School discovered two signaling pathways that are downregulated in human hearts after birth.

4 Aug 2022

UAB researchers report a potential treatment for ARID1A-deficient bladder cancer

Metastatic bladder cancer is generally incurable, so new therapies are an urgent need. Researchers at the University of Alabama at Birmingham now report a potential treatment for a quarter of bladder cancers.

4 Aug 2022

scRNA-seq of SARS-CoV-2 infected lung organoids finds NFKB Inhibitor Alpha increased in infected cells

Researchers develop a genetically modified airway organoid system, which overcomes challenges related to natural variations in ACE2 levels

4 Aug 2022

Researchers uncover genomic characteristics of breast cancers associated with PTEN hamartoma tumor syndrome

Cleveland Clinic researchers have uncovered genomic characteristics of breast cancers associated with PTEN hamartoma tumor syndrome (PHTS) that differentiate them from sporadic breast cancers.

4 Aug 2022

Novel fusion protein drug for Alzheimer’s disease circumvents the neurotoxic inflammatory side effects

Although Aduhelm, a monoclonal antibody targeting amyloid beta (Aβ), recently became the first US FDA approved drug for Alzheimer's disease (AD) based on its ability to decrease Aβ plaque burden in AD patients, its effect on cognitive improvement is still controversial.

4 Aug 2022

Protein C News and Research

Boosting vitamin D in individuals with deficiencies likely to reduce chronic inflammation

Optically controlled local heat-pulse method manipulates temperature in cells

NIH researchers develop three-dimensional structure of twinkle protein

Researchers develop new method for visualizing single cell protein secretion with stunning resolution

Researchers delve deeper into the structure of protein receptor crucial for cardiovascular health

Vitamin B12, folic acid supplements could potentially halt or reverse advanced form of fatty liver disease

New method can modify an entire substance class of medically relevant natural products

Researchers analyze the genetic differentiation, diversity of Omicron variant during its early spread

Gut microbiota-derived metabolites offer protection against SARS-CoV-2

Study identifies broad-spectrum antibody that neutralizes SARS-CoV-2 variants of concern

Researchers identify mechanistic principles for engineering antibodies to enhance cadherin adhesion

Extracellular vesicle-based surface protein assay likely to lead to a better way to detect early-stage hepatocellular carcinoma

Eating fish and seafood reduces risk of rheumatoid arthritis

Discovery could prevent insulin resistance and have significant benefits for people with type 2 diabetes

Individual genetic defects lead to heart failure in different ways, consortium reports

Researchers discover two signaling pathways that are downregulated in human hearts after birth

UAB researchers report a potential treatment for ARID1A-deficient bladder cancer

scRNA-seq of SARS-CoV-2 infected lung organoids finds NFKB Inhibitor Alpha increased in infected cells

Researchers uncover genomic characteristics of breast cancers associated with PTEN hamartoma tumor syndrome

Novel fusion protein drug for Alzheimer’s disease circumvents the neurotoxic inflammatory side effects

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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