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Novasep selected to commercially biomanufacture Celladon's Mydicar API

Novasep, a leading supplier of services and technologies for the life sciences industry, today announces that it has entered into an agreement with Celladon, a clinical-stage biotechnology company. Novasep will prepare to supply the drug substance for MYDICAR®.

19 Feb 2015

Nicotine metabolite supports learning, memory by amplifying action of primary chemical messenger

Nicotine's primary metabolite supports learning and memory by amplifying the action of a primary chemical messenger involved in both, researchers report.

19 Feb 2015

Findings may help doctors recommend appropriate treatments, improve patient outcomes

Like a car's front and back bumpers, your cell's chromosomes are capped by "telomeres" that protect this genetic material against deterioration. Still, after enough replications, a chromosome's telomeres break down and once they reach a certain point of degradation, the cell dies. This is one reason that cells are mortal: telomeres only last so long. That is, unless the enzyme telomerase builds new material onto the worn telomeres to reinforce these chromosomal "bumpers". Telomere repair can be a good thing, but in some cases it's not: overactive telomerase can lengthen telomeres until a cell becomes immortal…leading to cancer.

18 Feb 2015

From the scent of geranium to cough medicine; A self-assembling catalyst helps to construct complex biological scaffolds

With great elegance nature builds up complex structures from simple building blocks. A central class of compounds are terpenes. More than 8000 terpenes and about 30,000 of the related terpenoids are currently known. They are the key substances for many biological and pharmaceutical functions.

18 Feb 2015

Polypropylene PCR plates

To ensure full compatibility with robotic systems, DNase / RNase- and pyrogen-free PCR plates from Porvair Sciences feature high rigidity to minimise distortion before and after thermal cycling.

From Porvair Sciences Limited 18 Feb 2015

Eliglustat drug improves liver, spleen size and hemoglobin level in adults with Gaucher disease type 1

Among previously untreated adults with Gaucher disease type 1, a genetic disease in which there is improper metabolism due to a defect in an enzyme, treatment with the drug eliglustat resulted in significant improvements in liver and spleen size hemoglobin level, and platelet count, according to a study in the February 17 issue of JAMA.

18 Feb 2015

Applying NMR to biological problems: an interview with Professor Arthur Palmer

Our current focus is on areas in protein folding, molecular recognition by proteins and also enzyme catalysis. NMR spin relaxation is one of the very powerful techniques in NMR for studying conformational dynamics in proteins or chemical kinetic processes.

From Bruker BioSpin Group 17 Feb 2015

Researchers identify molecule that plays key role in aggressive thyroid cancer, other cancers

Cancer researchers at Mayo Clinic's campus in Jacksonville, Florida, have identified a molecule they say is important to survival of anaplastic thyroid carcinoma (ATC) — a lethal tumor with no effective therapies.

17 Feb 2015

Scientists demonstrate the importance of RNA editing in melanoma development

The importance of RNA editing in melanoma has been demonstrated by scientists at The University of Texas MD Anderson Cancer Center. The study revealed that a lack of RNA editing, a process by which information inside RNA molecules is transformed, leads to tumor growth and progression through manipulation of proteins.

17 Feb 2015

Wistar researchers identify new therapeutic target for aggressive form of ovarian cancer

Ovarian cancer is the deadliest of all cancers affecting the female reproductive system with very few effective treatments available. Prognosis is even worse among patients with certain subtypes of the disease. Now, researchers at The Wistar Institute have identified a new therapeutic target in a particularly aggressive form of ovarian cancer, paving the way for what could be the first effective targeted therapy of its kind for the disease.

16 Feb 2015

New study finds promising target for future therapies to treat breast and ovarian cancer patients

The Food and Drug Administration's recent approval of the drug olaparib for ovarian cancer patients with inherited mutations in the genes BRCA1 or BRCA2 came as welcome news to the thousands of women now eligible to receive it. A new study by Dana-Farber Cancer Institute scientists indicates that the pool of patients who can benefit from the drug is potentially much wider - and offers a ready means of identifying them.

16 Feb 2015

Research findings may point to new treatment for patients with Mitofusin 2 deficiency

Researchers have discovered a novel role for Mitofusin 2, and the findings may point to a new treatment for patients with diseases caused by loss of the mitochondrial protein.

16 Feb 2015

KU Leuven researchers find aggressive form of HIV in Cuba

Engaging in unprotected sex with multiple partners increases the risk of contracting multiple strains of HIV, the virus that causes AIDS. Once inside a host, these strains can recombine into a new variant of the virus. One such recombinant variant observed in patients in Cuba appears to be much more aggressive than other known forms of HIV.

16 Feb 2015

NTU Singapore setting up new institute to find cures for human diseases

Nanyang Technological University is setting up a new institute to advance research in the life sciences, with a focus on ramping up Singapore's efforts in finding cures for human diseases.

16 Feb 2015

Study suggests introduction of specific NGF to prevent neuronal degradation in Alzheimer's patients

Scientists at Karolinska Institutet have evaluated a new Alzheimer's therapy in which the patients receive an implant that stimulates the growth of a certain type of nerve cell. The results, which are published in the scientific journal Alzheimer's & Dementia, suggest that the introduction of a nerve growth factor can prevent neuronal degradation in Alzheimer's patients.

16 Feb 2015

Enzyme News and Research

Novasep selected to commercially biomanufacture Celladon's Mydicar API

Nicotine metabolite supports learning, memory by amplifying action of primary chemical messenger

Findings may help doctors recommend appropriate treatments, improve patient outcomes

From the scent of geranium to cough medicine; A self-assembling catalyst helps to construct complex biological scaffolds

Polypropylene PCR plates

Eliglustat drug improves liver, spleen size and hemoglobin level in adults with Gaucher disease type 1

Applying NMR to biological problems: an interview with Professor Arthur Palmer

Researchers identify molecule that plays key role in aggressive thyroid cancer, other cancers

Scientists demonstrate the importance of RNA editing in melanoma development

Wistar researchers identify new therapeutic target for aggressive form of ovarian cancer

New study finds promising target for future therapies to treat breast and ovarian cancer patients

Research findings may point to new treatment for patients with Mitofusin 2 deficiency

KU Leuven researchers find aggressive form of HIV in Cuba

NTU Singapore setting up new institute to find cures for human diseases

Study suggests introduction of specific NGF to prevent neuronal degradation in Alzheimer's patients

UT Southwestern researchers identify common signaling mechanism that controls immune system

Mechanistic subtypes of IPAH revealed

Immune system exploits flu virus' dependence on host's machinery

Thync electrical neurosignaling reduces brain's response to stress, shows study

Scientists find that treating the uninjured side of brain can maximize stroke recovery

Measuring Drug-Target Residence Times with Biochemical Assays eBook

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Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

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Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo