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Gene offers new insights into treatment strategies for deep-vein thrombosis

A gene associated with both protection against bacterial infection and excessive blood clotting could offer new insights into treatment strategies for deep-vein thrombosis -- the formation of a harmful clot in a deep vein.

9 May 2013

Seven-year quest to understand how breast cancer cells resist treatment

A seven-year quest to understand how breast cancer cells resist treatment with the targeted therapy lapatinib has revealed a previously unknown molecular network that regulates cell death.

8 May 2013

Kinase inhibitors: an interview with Jan Hoflack, CSO of Oncodesign

Kinase inhibitors are molecules that block the activity of kinases. Kinases are a specific class of enzymes. They are extremely important in signal transduction processes in the human body meaning that they actually regulate most of the physiological processes that take place in the body.

7 May 2013

Mutant protein contributes to Hutchinson-Gilford Progeria syndrome

A mutant protein responsible for Hutchinson-Gilford Progeria syndrome (HGPS) bars large proteins from entering the nucleus, according to a study in The Journal of Cell Biology.

7 May 2013

Pharmapendium adds new module to benefit researchers and toxicologists

Elsevier, a world-leading provider of scientific, technical and medical information products and services, today announces that PharmaPendium, the leading source of preclinical, clinical and post-market data, has added a new module to its content base, the Metabolizing Enzymes and Transporters Module.

6 May 2013

Novel screening method for identifying inhibitors of EZH2 methyltransferase

Tumor repressor genes, which inhibit tumor formation, can be "turned off" due to undesirable molecular changes affecting the chromosomes on which the genes reside. Understanding and being able to control these alterations could lead to new approaches for activating or inactivating genes linked to cancer.

5 May 2013

Researchers develop injectable nano-network to control blood-sugar levels

In a promising development for diabetes treatment, researchers have developed a network of nanoscale particles that can be injected into the body and release insulin when blood-sugar levels rise, maintaining normal blood sugar levels for more than a week in animal-based laboratory tests.

4 May 2013

Gene mutation associated with rare sleep disorder also contributes to debilitating migraines

A gene mutation associated with a rare sleep disorder surprisingly also contributes to debilitating migraines, a new discovery that could change the treatment of migraines by allowing development of drugs specifically designed to treat the chronic headaches.

3 May 2013

New mechanism that plays important role in meiosis identified

The Research Group headed by molecular biologist Andrea Pichler from the Max Planck Institute of Immunobiology and Epigenetics in Freiburg has made an important discovery in meiosis research.

3 May 2013

EPAC2 and diabetes: an interview with Dr. Hussain, Johns Hopkins University

EPAC stands for exchange protein activated by cyclic AMP (cAMP). cAMP is an (among many) intracellular messenger molecule. cAMP is generated when certain hormones stimulate a cell by binding to their receptor, which is at the outside surface of the cell.

3 May 2013

Variations in the sequencing of TERT gene influence risk of breast, ovarian cancers

A major international study involving a Simon Fraser University scientist has found that sequence differences in a gene crucial to the maintenance of our chromosomes' integrity predispose us to certain cancers.

3 May 2013

Synthetic anti-inflammatory substances related to marijuana may help fight HIV infection

HIV, the virus that causes AIDS, is notorious for hiding within certain types of cells, where it reproduces at a slowed rate and eventually gives rise to chronic inflammation, despite drug therapy.

2 May 2013

Study shows efficacy of PEGylated liposomal doxorubicin in intracranial model of breast cancer

Breast cancer brain metastases present a challenge to clinicians because there are few systemic therapies capable of crossing the blood-brain barrier to control the disease.

2 May 2013

Researchers identify genetic mutation linked to a typical form of migraine

A research team led by a Howard Hughes Medical Institute investigator at the University of California, San Francisco has identified a genetic mutation that is strongly associated with a typical form of migraine.

2 May 2013

Wistar researchers find surprising role for RNA-editing protein in gene silencing

RNA, once considered a bit player in the grand scheme by which genes encode protein, is increasingly seen to have a major role in human genetics.

2 May 2013

Study: Biologic response modifying drugs can cause acute liver injury

A commonly used class of biologic response modifying drugs can cause acute liver injury with elevated liver enzymes, according to a new study in Clinical Gastroenterology and Hepatology, the official clinical practice journal of the American Gastroenterological Association.

30 Apr 2013

Enzyme News and Research

Gene offers new insights into treatment strategies for deep-vein thrombosis

Seven-year quest to understand how breast cancer cells resist treatment

Kinase inhibitors: an interview with Jan Hoflack, CSO of Oncodesign

Mutant protein contributes to Hutchinson-Gilford Progeria syndrome

Pharmapendium adds new module to benefit researchers and toxicologists

Novel screening method for identifying inhibitors of EZH2 methyltransferase

Researchers develop injectable nano-network to control blood-sugar levels

Gene mutation associated with rare sleep disorder also contributes to debilitating migraines

New mechanism that plays important role in meiosis identified

EPAC2 and diabetes: an interview with Dr. Hussain, Johns Hopkins University

Variations in the sequencing of TERT gene influence risk of breast, ovarian cancers

Synthetic anti-inflammatory substances related to marijuana may help fight HIV infection

Study shows efficacy of PEGylated liposomal doxorubicin in intracranial model of breast cancer

Researchers identify genetic mutation linked to a typical form of migraine

Wistar researchers find surprising role for RNA-editing protein in gene silencing

Study: Biologic response modifying drugs can cause acute liver injury

Scientists discover novel drug molecule that reduces swelling, inflammation in arthritic joints

Pancreatitis and diabetes drugs: an interview with Dr Sonal Singh, Johns Hopkins University School of Medicine

New study sheds light on DEAD-box proteins

Researchers identify how proteasome takes care of unwanted, potentially toxic proteins

Biochemistry eBook

Revolutionizing Life Science: An Interview with SCIEX on ASMS, the SCIEX 7500+ System, and AI-Driven Quantitation

From Discovery Biology to ELRIG Chair

Breathing New Life into Diagnostics: Plasmion's SICRIT Technology

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