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Scientists develop a method of targeted drug delivery to cancer cells

A team of scientists from Peter the Great St.Petersburg Polytechnic University together with their colleagues developed a method of targeted drug delivery to cancer cells. The discovery is based on the use of mesenchymal stem cells and microcapsules made of polymeric compounds.

9 Dec 2019

Study shows safety of palbociclib for advanced breast cancer patients with unique gene alteration

Women who receive palbociclib (Ibrance) to treat their advanced breast cancer and have a gene alteration that can lead to a condition known as benign ethnic neutropenia (BEN), can safely receive the drug without major concerns of developing infections associated with neutropenia, or low white blood cell counts, say Georgetown Lombardi Comprehensive Cancer Center researchers.

9 Dec 2019

$Experimental immunotherapy can put patients with relapsed or refractory lymphoma into remission$

Experimental immunotherapy can put patients with relapsed or refractory lymphoma into remission

A new, experimental immunotherapy can put patients with B-cell non-Hodgkin lymphoma (NHL) that is resistant to or has come back after multiple other therapies, including CAR T therapy, into remission.

8 Dec 2019

The role of adenosine in neurodegeneration and brain regeneration

The role of adenosine in neurodegeneration and neuroregeneration has led to growing attention on adenosine receptors as potential drug targets in a range of brain disorders, including neuroregenerative therapy and treatment for amyotrophyic lateral sclerosis.

8 Dec 2019

Multiplexed C dots track different cancer targets to improve treatment

For more than a decade, researchers have used glowing nanoparticles called Cornell dots, or C dots, to illuminate cancer cells, target tumors and even induce cell death.

6 Dec 2019

Researchers identify a missed opportunity in the treatment of ER+ breast cancers

In the United States, apart from some forms of skin cancer, breast cancer is the most common cancer in women. It is also the most common cause of death from cancer among Hispanic women and the second most common among all other women, after lung cancer.

6 Dec 2019

Researchers confirm two new prognostic markers for triple negative breast cancer

Physicians who treat patients with triple negative breast cancer have two new ways to predict which patients may benefit most from the well-established post-surgery treatment known as AC chemotherapy, short for adjuvant doxorubicin and cyclophosphamide.

5 Dec 2019

New approach can improve the activity of CAR-T cells against blood and solid cancers

A new approach to programing cancer-fighting immune cells called CAR-T cells can prolong their activity and increase their effectiveness against human cancer cells grown in the laboratory and in mice, according to a study by researchers at the Stanford University School of Medicine.

5 Dec 2019

$Nerve signaling pathway crucial to healing fractures, study shows$

Nerve signaling pathway crucial to healing fractures, study shows

Sticks and stones may break one's bones, but healing them requires the production of a protein signal that stimulates the generation, growth and spread of vital nerve cells, or neurons, throughout the injured area.

5 Dec 2019

Transitional T cells could help improve cancer immunotherapy

In chronic viral infections and cancer, T cell dysfunction is sure to be observed. A new study to be published in the journal Immunity shows that before these cells are completely exhausted, there is a transitory stage in which some cells are present with features that are characteristic of neither the stem-like T cells nor the mature but exhausted T cells.

4 Dec 2019

New method for discovering potential cancer-treating compounds

A new study published in the journal Cell Reports reports a novel method by which antitumor drugs that focus on reawakening exhausted immune cells called cytotoxic T cells against cancer can be quickly identified. This could help treat a large subset of cancers that thrive because of their ability to suppress antitumor activity in T cells.

4 Dec 2019

Gabapentin – a drug for nerve pain could help patients with spinal injury finds study

A preclinical study with mice has shown that Gabapentin, a drug that is commonly used in nerve pain could be useful for patients with spinal cord injury. Use of the drug showed improvement in upper limb function among the mice models of spinal cord injury, wrote the researchers. The study titled, “Gabapentinoid treatment promotes corticospinal plasticity and regeneration following murine spinal cord injury,” was published this week in the latest issue of the Journal of Clinical Investigation.

4 Dec 2019

Researchers move one step closer to understanding complex physiology of CKD patients

Researchers have further analyzed a known signaling pathway they believe brings them one step closer to understanding the complex physiology of patients with chronic kidney disease (CKD), which might provide a path to new treatment options.

4 Dec 2019

Researchers investigate NOTCH1 mutations in keratinocyte lines derived from OSCC biopsies

The cover for issue 63 of Oncotarget features Figure 6, "Inverse relationship between ETV7 and SERPINE1 in OSCC," by Salameti, et al.

4 Dec 2019

Cancer patients receiving common heart drugs have less heart damage from cancer therapy

Cancer patients receiving common heart drugs have less heart damage from cancer therapy, according to research presented today at EuroEcho 2019, a scientific congress of the European Society of Cardiology.

4 Dec 2019

Common drug for nerve pain could help restore upper limb function after spinal cord injury

Long-term treatment with gabapentin, a commonly prescribed drug for nerve pain, could help restore upper limb function after a spinal cord injury, new research in mice suggests.

3 Dec 2019

New screening method can rapidly discover potential cancer-treating compounds

Scientists at Scripps Research have developed a method for rapidly discovering potential cancer-treating compounds that work by resurrecting anti-tumor activity in immune cells called T cells.

3 Dec 2019

Common cold virus could infect fetus via placenta

According to researchers, the common cold viruses are capable of infecting human placental cells and may thus transmit the infection to the fetus in the womb during pregnancy. The new study was published in the journal PLOS ONE, and provides the first concrete proof that this type of carriage is possible.

3 Dec 2019

Roswell Park-led scientists identify new defense mechanism against prostate cancer

A research team led by a scientist at Roswell Park Comprehensive Cancer Center has identified the molecule LRIG1 as an important endogenous tumor suppressor in prostate cancer. Writing in the journal Nature Communications, the team documents their findings from preclinical studies showing that overexpression of the LRIG1 protein inhibits prostate cancer development, while reducing naturally occurring LRIG1 promotes prostate tumor development.

3 Dec 2019

Inhibition of a protease could improve the treatment of IBD, study shows

Scientists at the Centro Nacional de Investigaciones Cardiovasculares and the Centro de Investigaciones Biológicas of the Consejo Superior de Investigaciones Científicas have identified the protease MT1-MMP as a possible future target for drugs to treat inflammatory bowel disease.

3 Dec 2019

Receptor News and Research

Scientists develop a method of targeted drug delivery to cancer cells

Study shows safety of palbociclib for advanced breast cancer patients with unique gene alteration

Experimental immunotherapy can put patients with relapsed or refractory lymphoma into remission

The role of adenosine in neurodegeneration and brain regeneration

Multiplexed C dots track different cancer targets to improve treatment

Researchers identify a missed opportunity in the treatment of ER+ breast cancers

Researchers confirm two new prognostic markers for triple negative breast cancer

New approach can improve the activity of CAR-T cells against blood and solid cancers

Nerve signaling pathway crucial to healing fractures, study shows

Transitional T cells could help improve cancer immunotherapy

New method for discovering potential cancer-treating compounds

Gabapentin – a drug for nerve pain could help patients with spinal injury finds study

Researchers move one step closer to understanding complex physiology of CKD patients

Researchers investigate NOTCH1 mutations in keratinocyte lines derived from OSCC biopsies

Cancer patients receiving common heart drugs have less heart damage from cancer therapy

Common drug for nerve pain could help restore upper limb function after spinal cord injury

New screening method can rapidly discover potential cancer-treating compounds

Common cold virus could infect fetus via placenta

Roswell Park-led scientists identify new defense mechanism against prostate cancer

Inhibition of a protease could improve the treatment of IBD, study shows

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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