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Oral gavage is not appropriate for hazard assessments of EDCs, say researchers

Challenging risk assessment methods used for decades by toxicologists, a new review of the literature led by environmental health scientist Laura Vandenberg at the University of Massachusetts Amherst suggests that oral gavage, the most widely accepted method of dosing lab animals to test chemical toxicity, does not accurately mimic how humans are exposed to chemicals in everyday life.

25 Jun 2014

Research finding could open new opportunities for treating Huntington's disease

Researchers believe they have learned how mutations in the gene that causes Huntington's disease kill brain cells, a finding that could open new opportunities for treating the fatal disorder. Scientists first linked the gene to the inherited disease more than 20 years ago

24 Jun 2014

Alcoholic liver disease: an interview with Dr Vinood Patel, University of Westminster

Alcoholic liver disease (ALD) is one of the leading causes of death worldwide and also in the UK. As its name indicates this disease arises due to consuming excessive amounts of alcohol (80 g/day) over an extended period, normally 10-20 years.

24 Jun 2014

Antiviral therapy can reduce risk of liver cancer in patients with chronic hepatitis B infection

One of the most severe complications of hepatitis B is the development of liver cancer, which is responsible for approximately 745,000 deaths worldwide each year.

24 Jun 2014

Researchers shown how free radicals contribute to fatty liver disease

An international team of scientists led by Monash University researchers has shown how free radicals contribute to type 2 diabetes, obesity and fatty liver disease.

23 Jun 2014

Bayer, Dimension Therapeutics partner to develop new gene therapy for hemophilia A

Dimension Therapeutics, a company focused on developing novel adeno-associated virus (AAV) gene therapy treatments for rare diseases, today announced it has entered into a collaboration with Bayer HealthCare (Bayer) for the development and commercialization of a novel gene therapy for the treatment of hemophilia A.

23 Jun 2014

New concept of organs on a chip may help study cancer metastasis

The recent development of the concept of organs on a chip opens the possibility of realistically studying human organs without the use of patients or animal testing.

23 Jun 2014

Celsion acquires all assets of EGEN

Celsion Corporation, an oncology drug development company, today announced the completion of the acquisition by Celsion of substantially all of the assets of EGEN, Inc., a privately-held biopharmaceutical company focused on the development of nucleic acid-based therapeutics for the treatment of cancer and other difficult to treat diseases.

21 Jun 2014

Greenlander study identifies single mutation with large diabetes risk

Researchers have used a Greenlandic cohort to identify a genetic mutation whose effect on the risk of diabetes is “several times larger” than any previously discovered.

20 Jun 2014

Continuation of metformin after cirrhosis diagnosis improves survival rates in diabetes patients

Researchers at Mayo Clinic released a new study reversing current thought on the treatment of cirrhotic patients with type 2 diabetes.

20 Jun 2014

Yap1 oncogene drives recurrence and progression of pancreatic cancer

Pancreatic cancer tumors addicted to mutant Kras signaling for their growth and progression have a ready-made substitute to tap if they're ever forced to go cold-turkey on the mutant oncogene, scientists at The University of Texas MD Anderson Cancer Center report in the journal Cell.

20 Jun 2014

Clinical trial shows that selumetinib drug can delay progression of metastatic uveal melanoma

For the first time, a therapy has been found that can delay progression of metastatic uveal melanoma, a rare and deadly form of melanoma of the eye.

20 Jun 2014

Research provides unique insight into lncRNAs that regulate lung development

It's a long way from DNA to RNA to protein, and only about two percent of a person's genome is eventually converted into proteins.

19 Jun 2014

Mayo Clinic study: Reversing current thought on treatment of cirrhotic patients with type 2 diabetes

Researchers at Mayo Clinic released a new study reversing current thought on the treatment of cirrhotic patients with type 2 diabetes. The study found that the continuation of metformin after a cirrhosis diagnosis improved survival rates among diabetes patients.

19 Jun 2014

Healthy inflammation necessary to prevent metabolic diseases, study finds

Chronic tissue inflammation is typically associated with obesity and metabolic disease, but new research from UT-Southwestern Medical Center now finds that a level of "healthy" inflammation is necessary to prevent metabolic diseases, such as fatty liver.

19 Jun 2014

Common mutation in gene with overweight results in elevated ALAT values in children

A study carried out at the Institute of Biomedicine of the University of Eastern Finland shows that a common mutation in the PNPLA3 gene combined with overweight results in elevated ALAT values in children.

18 Jun 2014

Genetic variants linked to race that explains risk of death among patients taking Plavix after heart attack

Researchers have identified the first genetic variations linked to race that begin to explain a higher risk of death among some African American and Caucasian patients taking the anti-clotting drug clopidogrel (Plavix) after a heart attack.

18 Jun 2014

Western Oncolytics closes $275,000 in seed funding

Western Oncolytics Ltd., a biotech company specializing in immuno-oncolytic cancer therapies, has closed $275,000 in seed funding. The proceeds are planned to set a path toward clinical trials and execute initial manufacturing for its novel virus-based cancer therapy, which delivers genes to guide the immune system to kill cancer cells.

18 Jun 2014

New clinical guidelines on diagnosis and management of idiosyncratic DILI

New clinical guidelines on the diagnosis and management of idiosyncratic drug-induced liver injury (DILI) appear in the July issue of The American Journal of Gastroenterology.

18 Jun 2014

Transfer of few immune cells can protect immunodeficient patients

The cells of the human immune system are created from special stem cells in the bone marrow. In diseases affecting the bone marrow, such as leukemia, the degenerate cells must be destroyed using radiation or chemotherapy.

18 Jun 2014

Liver News and Research

Oral gavage is not appropriate for hazard assessments of EDCs, say researchers

Research finding could open new opportunities for treating Huntington's disease

Alcoholic liver disease: an interview with Dr Vinood Patel, University of Westminster

Antiviral therapy can reduce risk of liver cancer in patients with chronic hepatitis B infection

Researchers shown how free radicals contribute to fatty liver disease

Bayer, Dimension Therapeutics partner to develop new gene therapy for hemophilia A

New concept of organs on a chip may help study cancer metastasis

Celsion acquires all assets of EGEN

Greenlander study identifies single mutation with large diabetes risk

Continuation of metformin after cirrhosis diagnosis improves survival rates in diabetes patients

Yap1 oncogene drives recurrence and progression of pancreatic cancer

Clinical trial shows that selumetinib drug can delay progression of metastatic uveal melanoma

Research provides unique insight into lncRNAs that regulate lung development

Mayo Clinic study: Reversing current thought on treatment of cirrhotic patients with type 2 diabetes

Healthy inflammation necessary to prevent metabolic diseases, study finds

Common mutation in gene with overweight results in elevated ALAT values in children

Genetic variants linked to race that explains risk of death among patients taking Plavix after heart attack

Western Oncolytics closes $275,000 in seed funding

New clinical guidelines on diagnosis and management of idiosyncratic DILI

Transfer of few immune cells can protect immunodeficient patients

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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