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Study: Calcium signaling can help address drug resistance to non-Hodgkin lymphoma

Gene expression profiling and other analyses conducted by Rutgers Cancer Institute of New Jersey researchers and colleagues examining drug resistance to a common antibody therapy for non-Hodgkin lymphoma have identified calcium signaling as a novel and exploitable target in overcoming this treatment obstacle.

3 Dec 2019

New computational method can help predict and design allosteric functions in proteins

Called the "second secret of life", allostery is one of the most fundamental processes of biology and has been a central focus among scientists across the life sciences spectrum, from fundamental biology to drug development.

3 Dec 2019

Key component of immune response is activated by short RNAs, shows study

Ludwig-Maximilians-Universitaet (LMU) in Munich researchers report that a central component of the innate immune response is activated by two short RNAs which are produced by site-specific cleavage of a precursor RNA molecule - and both derivatives are generated by the same enzyme.

3 Dec 2019

Virome analysis reveals clues for increased risk of type 1 diabetes in children

New results from The Environmental Determinants of Diabetes in the Young study show an association between prolonged enterovirus infection and the development of autoimmunity to the insulin-producing pancreatic beta-cells that precedes type 1 diabetes.

2 Dec 2019

Brain receptor that regulates body temperature may also be the key to rapid weight loss

The brain mechanism that enables us to maintain a constant body temperature may also be the key to rapid weight loss, a new study finds.

2 Dec 2019

Researchers uncover the binding mechanism of opioid receptor

Together with colleagues from Shanghai, Brussels, Canada and the USA, researchers from the University of Bonn have uncovered the binding mechanism of an important pain receptor.

27 Nov 2019

State-of-the-art expert reviews provide insights into vitamin D research

Vitamin D is essential for human health. Although much is known about its important role in bone metabolism and in certain areas of non-skeletal health, there are many open questions and topics of debate.

27 Nov 2019

Helper protein exacerbates diabetic macular edema

In a recent study using mice, lab-grown human retinal cells and patient samples, Johns Hopkins Medicine scientists say they found evidence of a new pathway that may contribute to degeneration of the light sensitive tissue at the back of the eye.

27 Nov 2019

Attacking HIV at the source

A new study published on November 26, 2019, in the journal Cell Reports, details a new discovery that may help avert HIV infection right at the start. The virus is known to take a long time to infect a person, and the scientists say they have found a period during which it can be weakened or killed, in the very first hours after it has entered a host. They call this the window of vulnerability.

26 Nov 2019

Looking for the source: new routes for allergy treatment

A new multinational study has reported a very full account of the B lymphocytes that produce group E antibodies, also called IgE (Immunoglobulin E), that are behind allergic reactions, which are common in up to a third of the world’s population.

26 Nov 2019

Mcl-1 inhibition blocks cell survival in ER+ breast cancers

While estrogen receptor - + breast cancers express high levels of three anti-apoptotic Bcl-2 family members, pharmacological inhibition of Bcl-2 and/or Bcl-xL fails to induce cell death in ER + breast cancer cell lines, due to rapid and robust Mcl-1 upregulation.

26 Nov 2019

Giving a shot of ketamine could help heavy drinkers reduce alcohol intake

A one-off dose of ketamine could help heavy drinkers reduce their alcohol intake, finds a new UCL experimental study.

26 Nov 2019

New way to thwart HIV infection at early stages

1.7 million. That's how many people are infected with the human immunodeficiency virus (HIV) each year worldwide. 1.7 million people who are condemned to lifelong antiretroviral therapy (ART) or risk developing fatal AIDS . Out of the 37.9 million people living with HIV (PLWH), 22.3 million have access to ART, allowing them to have an almost normal lifespan.

26 Nov 2019

Key mechanism identified for how antiviral immune responses reprogram liver metabolism

Researchers at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences identified a key mechanism for how antiviral immune responses reprogram liver metabolism. Their recent study, which was published in the renowned scientific journal Immunity, investigated the communication between inflammation and liver metabolism during chronic viral infection.

26 Nov 2019

Tandem radiation therapy effective in prostate cancer patients with no treatment options

Reports of new cancer treatments often raise high hopes and expectations, particularly, of course, among cancer patients and their families.

26 Nov 2019

Women treated for early-stage breast cancer may develop invasive breast cancer

New research in the November 2019 issue of JNCCN—Journal of the National Comprehensive Cancer Network examines the implications of invasive breast cancer after breast-conserving treatment for ductal carcinoma in situ (aka DCIS, a form of non-invasive breast cancer) and which factors could impact overall survival.

25 Nov 2019

New targeted treatment to fight against deadly pancreatic cancer

Every day, more than 1200 people worldwide are told they have pancreatic cancer. Within 12 months, 80 per cent of them will have succumbed to the disease.

25 Nov 2019

Breast-conserving treatment may be a viable alternative to mastectomy, study suggests

Approximately 10% of breast cancer patients treated with lumpectomy (breast-conserving surgery [BCS]) and whole-breast radiation (WBI) will have a subsequent in-breast local recurrence of cancer (IBTR) when followed long term.

22 Nov 2019

New study provides better understanding of blood clot formation in cancer patients

Researchers have identified a potential new signaling pathway that may help further the understanding of blood clot formation in cancer patients and ultimately help prevent this complication from occurring.

22 Nov 2019

Biosimilar for HER2+ breast cancer achieves similar overall response rate to reference drug

The trastuzumab biosimilar HLX02 achieved similar overall response rate to reference trastuzumab in women with human epidermal growth factor receptor 2-positive (HER2+) recurrent or previously untreated metastatic breast cancer, according to a large, randomized phase III study reported at the ESMO Asia 2019 Congress.

22 Nov 2019

Receptor News and Research

Study: Calcium signaling can help address drug resistance to non-Hodgkin lymphoma

New computational method can help predict and design allosteric functions in proteins

Key component of immune response is activated by short RNAs, shows study

Virome analysis reveals clues for increased risk of type 1 diabetes in children

Brain receptor that regulates body temperature may also be the key to rapid weight loss

Researchers uncover the binding mechanism of opioid receptor

State-of-the-art expert reviews provide insights into vitamin D research

Helper protein exacerbates diabetic macular edema

Attacking HIV at the source

Looking for the source: new routes for allergy treatment

Mcl-1 inhibition blocks cell survival in ER+ breast cancers

Giving a shot of ketamine could help heavy drinkers reduce alcohol intake

New way to thwart HIV infection at early stages

Key mechanism identified for how antiviral immune responses reprogram liver metabolism

Tandem radiation therapy effective in prostate cancer patients with no treatment options

Women treated for early-stage breast cancer may develop invasive breast cancer

New targeted treatment to fight against deadly pancreatic cancer

Breast-conserving treatment may be a viable alternative to mastectomy, study suggests

New study provides better understanding of blood clot formation in cancer patients

Biosimilar for HER2+ breast cancer achieves similar overall response rate to reference drug

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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