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Testing for dangerous 'zombie' cells could increase the number of donor hearts for transplant

Testing older potential organ donors for dangerous 'zombie' cells could help to increase the number of hearts available for transplant, according to research part-funded by the British Heart Foundation (BHF) and presented at the British Cardiovascular Society conference in Manchester.

4 Jun 2023

Stopping treatment at two years does not seem to compromise overall survival in patients with advanced lung cancer

Over the past decade, the approval of immune checkpoint inhibitors has revolutionized treatment for patients with advanced lung cancer, helping many live longer lives and improving overall survival for the disease.

4 Jun 2023

Study shows efficacy and safety of novel FolRα-targeting antibody drug conjugate in recurrent epithelial ovarian cancer

Updated dose expansion data of the phase I STRO-002-GM1 study have been presented today by Ana Oaknin, Principal Investigator of the Vall d'Hebron Institute of Oncology's (VHIO) Gynecological Malignancies Group, on the ground at the 2023 Annual Meeting of the American Society of Clinical Oncology (ASCO), 2-6 June in Chicago, USA.

4 Jun 2023

Groundbreaking study maps molecular architecture of the visual system's integral components

A groundbreaking study has taken a significant step towards understanding the complexities of the human eye.

4 Jun 2023

Multiple sclerosis: Immune cell invasion enabled by blood-brain barrier breakdown

Blood-brain barrier breakdown in multiple sclerosis leads to immune cell infiltration into the central nervous system. Antigen presentation at the barrier promotes CD8+ T cell entry, triggering focal breakdown and hindering their invasion.

4 Jun 2023

Study offers the most comprehensive archive of cellular, molecular features involved in psoriatic disease

Beneath and beyond the reddish, flaky lesions that form in the skin of those with psoriasis, mild and severe forms of the disease can be told apart by the activity of key cells and signaling pathways, a new study shows.

2 Jun 2023

Researchers characterize a unique molecular mechanism of early stages of programmed cell death

Researchers have for the first time characterized a unique molecular mechanism of the early stages of programmed cell death or apoptosis, a process which plays a crucial role in prevention of cancer.

2 Jun 2023

Study of immunotherapy for brain cancer metastases shows promising results

In a phase 2 clinical trial of the immune checkpoint inhibitor pembrolizumab, investigators found that 42 percent of patients with metastatic brain cancer benefited from the therapy, with seven patients in the trial surviving longer than two years.

2 Jun 2023

Exposure to Agent Orange associated with increased risk of myeloproliferative neoplasms in veterans

Research conducted at Georgetown University's Lombardi Comprehensive Cancer Center and the Washington DC VA Medical Center on a database of veterans exposed to Agent Orange found an association for an increased risk of developing myeloproliferative neoplasms (MPNs), which are acquired stem cell disorders that can lead to overproduction of mature blood cells complicated by an increased risk of blood clots in arteries and veins.

2 Jun 2023

High levels of memory killer cells correlate with better survival in melanoma patients

Our skin contains specialized long-lived killer cells that protect against intruders. Researchers at Karolinska Institutet in Sweden and the University of Copenhagen in Denmark have now identified how these cells are formed, and shown that high levels of memory killer cells in cancer tissue correlate with a better survival rate in people with melanoma.

2 Jun 2023

Lymphoid depletion associated with suppressed APC function characterizes the lethality of COVID-19 in mice

Individuals who are immunocompromised are considered at higher risk for severe or longer disease with COVID-19. Understanding the systemic immune response is vital for research efforts to reduce its effects on multiple organs.

2 Jun 2023

MatTek and AIM Biotech Partner on Advanced 3D Tissue Culture Organ-on-a-Chip Systems

Today, MatTek Life Sciences and AIM Biotech announced a strategic partnership through which the AIM Biotech portfolio will be available for sale through MatTek.

From MatTek Corporation 2 Jun 2023

How does a riboswitch regulate its own synthesis?

To prevent a global health crisis, scientists around the world are searching for ways to fight bacteria that can evade the current arsenal of antibiotics.

2 Jun 2023

Novel technology helps analyze tumor growth in another dimension

Tumors are composed of rapidly multiplying cancer cells. Understanding which biochemical processes fuel their relentless growth can provide hints at therapeutic targets.

2 Jun 2023

Scientists investigate how immune system's T cells could fight many coronaviruses at once

Scientists at La Jolla Institute for Immunology (LJI) are investigating how the immune system's T cells react to a wide variety of coronaviruses, ranging from SARS to common cold coronaviruses.

1 Jun 2023

RNA regulatory mechanism could be targeted to slow AD progression mediated by stress granules

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 10, entitled, "Stress granules sequester Alzheimer's disease-associated gene transcripts and regulate disease-related neuronal proteostasis."

1 Jun 2023

St. Jude researchers discover NLRP12 as a direct bridge from hemolysis to inflammatory disease

Infections and other diseases can cause red blood cells to rupture, releasing the oxygen-binding molecule hemoglobin, which breaks down into heme.

1 Jun 2023

MFAP5, a microfibril-associated protein, unveiled as key player in scar formation and wound healing

MFAP5, a microfibril-associated protein, plays a significant role in wound healing by regulating fibroblast function, collagen deposition, and angiogenesis, suggesting its potential as a modulator of scar formation.

1 Jun 2023

NCCN collaborates with K Hospital and Vietnam Cancer Association to improve standards for cancer care

he National Comprehensive Cancer Network - a not-for-profit alliance of leading cancer centers in the United States - today announced the signing of a Memo of Understanding (MOU) with Vietnam National Cancer Hospital ("K Hospital") and the Vietnam Cancer Association to work together to improve standards for cancer care throughout the country.

1 Jun 2023

Parkinson's disease drug ropinirole is safe and tolerable for ALS patients, early clinical trial shows

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a fatal motor neuron disease that causes people to gradually lose control of their muscles.

1 Jun 2023

B Cell News and Research

Testing for dangerous 'zombie' cells could increase the number of donor hearts for transplant

Stopping treatment at two years does not seem to compromise overall survival in patients with advanced lung cancer

Study shows efficacy and safety of novel FolRα-targeting antibody drug conjugate in recurrent epithelial ovarian cancer

Groundbreaking study maps molecular architecture of the visual system's integral components

Multiple sclerosis: Immune cell invasion enabled by blood-brain barrier breakdown

Study offers the most comprehensive archive of cellular, molecular features involved in psoriatic disease

Researchers characterize a unique molecular mechanism of early stages of programmed cell death

Study of immunotherapy for brain cancer metastases shows promising results

Exposure to Agent Orange associated with increased risk of myeloproliferative neoplasms in veterans

High levels of memory killer cells correlate with better survival in melanoma patients

Lymphoid depletion associated with suppressed APC function characterizes the lethality of COVID-19 in mice

MatTek and AIM Biotech Partner on Advanced 3D Tissue Culture Organ-on-a-Chip Systems

How does a riboswitch regulate its own synthesis?

Novel technology helps analyze tumor growth in another dimension

Scientists investigate how immune system's T cells could fight many coronaviruses at once

RNA regulatory mechanism could be targeted to slow AD progression mediated by stress granules

St. Jude researchers discover NLRP12 as a direct bridge from hemolysis to inflammatory disease

MFAP5, a microfibril-associated protein, unveiled as key player in scar formation and wound healing

NCCN collaborates with K Hospital and Vietnam Cancer Association to improve standards for cancer care

Parkinson's disease drug ropinirole is safe and tolerable for ALS patients, early clinical trial shows

Using single B cell screening to boost antibody discovery eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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