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Newly discovered molecule may be a potential therapeutic target for triple-negative breast cancer

A team of researchers from Hiroshima University has discovered a molecule that promotes the production of cancer cells. This molecule may prove to be a potential therapeutic target in the treatment of triple-negative breast cancer, an aggressive form of breast cancer.

27 Mar 2024

Breakthrough tool illuminates neural stem cell dynamics

Researchers can use the light naturally thrown off by biological specimens to better study the different states of stem cells in the nervous system, thanks to a tool developed at the University of Wisconsin–Madison, brightening their chances for studying the way stem cells age.

27 Mar 2024

New treatment paradigm focuses on reverting cancer cells to normal state

St. Jude Children's Research Hospital scientists reversed an aggressive cancer, reverting malignant cells towards a more normal state. Rhabdoid tumors are an aggressive cancer which is missing a key tumor suppressor protein.

27 Mar 2024

DNA damage in neurons crucial for creating stable memories

Just as you can't make an omelet without breaking eggs, scientists at Albert Einstein College of Medicine have found that you can't make long-term memories without DNA damage and brain inflammation. Their surprising findings were published online today in the journal Nature.

27 Mar 2024

Enzymatic cocktail emerges as new hope against mycobacterial infections

With resistance to chemical antibiotics on the rise, the world needs entirely new forms of antibiotics. A new study published in Microbiology Spectrum, a journal of the American Society for Microbiology, shows that an enzymatic cocktail can kill a variety of mycobacterial species of bacteria, including those that cause tuberculosis.

27 Mar 2024

Breakthrough discovery points to potential treatment for rare neurodegenerative disease

Imagine being middle-aged and starting to feel that you are off balance a lot and that you are having a hard time coordinating your movements.

27 Mar 2024

AI-powered method predicts protein dynamics to accelerate drug discovery

Understanding the structure of proteins is critical for demystifying their functions and developing drugs that target them.

27 Mar 2024

Xenotransplantation model used for studying microglial response to Alzheimer's disease

Microglia are specialized immune cells in the brain. While they normally protect our brains, they can also contribute to neurodegenerative diseases such as Alzheimer's.

27 Mar 2024

Exploring the link between prenatal nutrition and congenital craniofacial malformations

The complex development of craniofacial skeletal structures and improve treatments for congenital craniofacial malformations.

27 Mar 2024

New insights into the exacerbation of psoriasis through specific genetic defects

The inflammatory potential of tissue-resident regulatory T cells in a murine gain of function model.

27 Mar 2024

Focusing on oncogenic driver mutations and resistance mechanisms in the treatment of NSCLC

Lung cancer is the leading cause of cancer-related death worldwide. Improved understanding of driver mutations of non-small cell lung cancer (NSCLC) has led to more biomarker-directed treatment for patients with advanced stages.

26 Mar 2024

Household chemicals endanger brain's myelin-forming cells

Study uncovers how environmental chemicals, specifically organophosphate flame retardants and quaternary compounds, negatively affect oligodendrocyte development, implicating them in potential neurodevelopmental risks such as ADHD and autism, by employing an innovative high-throughput screening approach on mouse and human stem cell-derived models.

26 Mar 2024

Machine learning identifies key cellular communities in soft tissue sarcoma

Using novel machine learning tools developed at Stanford Medicine, researchers have mapped three distinct cellular configurations that correspond to clinical outcomes for patients with a rare, difficult-to-treat cancer called soft tissue sarcoma.

26 Mar 2024

Columbia researchers secure $38.95 million ARPA-H contract to build a living knee replacement

A team of researchers from Columbia University Irving Medical Center and Columbia Engineering has been awarded up to a $38.95 million contract from the Advanced Research Projects Agency for Health (ARPA-H) to build a living knee replacement from biomaterials and human stem cells, including a patient's own cells.

26 Mar 2024

New genetic system analyzes the underlying mechanisms of CRISPR-based DNA repair outcomes

Since its breakthrough development more than a decade ago, CRISPR has revolutionized DNA editing across a broad range of fields.

26 Mar 2024

Antioxidant-rich diets linked to lower type 2 diabetes risk, supplements less effective

Study systematically reviews the impact of dietary antioxidants, vitamins C, E, and beta-carotene, on reducing the risk of type 2 diabetes, suggesting an inverse association with the disease, though no protective effects from supplementation were observed.

26 Mar 2024

Organ-on-a-chip technology revolutionizes drug development for women's health

Women's bodies and their health in general have for too long been assigned low priority in the field of research.

26 Mar 2024

Study identifies brain energy metabolism dysfunction in neuropsychiatric disorders

A global collaborative research group comprising 131 researchers from 105 laboratories across seven countries announces a groundbreaking research paper submitted to eLife.

26 Mar 2024

GPT-4 shows expert-level accuracy in annotating cell types

GPT-4 can accurately interpret types of cells important for the analysis of single-cell RNA sequencing -- a sequencing process fundamental to interpreting cell types – with high consistency to that of time-consuming manual annotation by human experts of gene information, according to a study at Columbia University Mailman School of Public Health.

26 Mar 2024

ABT199/venetoclax synergism with thiotepa enhances cytotoxicity of chemo drugs in AML cells

A new research paper was published in Oncotarget's Volume 15 on March 14, 2024, entitled, "ABT199/venetoclax synergism with thiotepa enhances the cytotoxicity of fludarabine, cladribine and busulfan in AML cells."

26 Mar 2024

Cell News and Research

Newly discovered molecule may be a potential therapeutic target for triple-negative breast cancer

Breakthrough tool illuminates neural stem cell dynamics

New treatment paradigm focuses on reverting cancer cells to normal state

DNA damage in neurons crucial for creating stable memories

Enzymatic cocktail emerges as new hope against mycobacterial infections

Breakthrough discovery points to potential treatment for rare neurodegenerative disease

AI-powered method predicts protein dynamics to accelerate drug discovery

Xenotransplantation model used for studying microglial response to Alzheimer's disease

Exploring the link between prenatal nutrition and congenital craniofacial malformations

New insights into the exacerbation of psoriasis through specific genetic defects

Focusing on oncogenic driver mutations and resistance mechanisms in the treatment of NSCLC

Household chemicals endanger brain's myelin-forming cells

Machine learning identifies key cellular communities in soft tissue sarcoma

Columbia researchers secure $38.95 million ARPA-H contract to build a living knee replacement

New genetic system analyzes the underlying mechanisms of CRISPR-based DNA repair outcomes

Antioxidant-rich diets linked to lower type 2 diabetes risk, supplements less effective

Organ-on-a-chip technology revolutionizes drug development for women's health

Study identifies brain energy metabolism dysfunction in neuropsychiatric disorders

GPT-4 shows expert-level accuracy in annotating cell types

ABT199/venetoclax synergism with thiotepa enhances cytotoxicity of chemo drugs in AML cells

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