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HIV drugs cause immune-system changes that can improve resistance to viral infections

Drugs currently used to keep the HIV virus in check also cause immune-system changes that might make humans better able to resist viral infections – but might also cause harmful inflammation, according to a study published today in Cell Reports Medicine.

23 Sep 2020

Black young adults pay a higher price to achieve prosperity

The American dream of achieving prosperity requires hard work and sacrifice, and some Americans pay a higher price for that dream than others, according to a new study from University of Georgia researchers.

23 Sep 2020

Baseline T cell signatures predict clinical outcomes of SARS-CoV infection

In a recent bioRxiv preprint paper, researchers from the Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR, and Department of Global Health, University of Washington, Seattle, WA, discuss their study in mice that undergo detailed immunophenotyping before getting infected with SARS-CoV.

22 Sep 2020

Research explains why flu is dangerous for pregnant women

A team of researchers at the Royal Melbourne Institute of Technology (RMIT) University explains why flu can lead to potentially fatal complications during pregnancy, suggesting that the virus does not only stay in the respiratory tract but spreads throughout the body.

22 Sep 2020

Phase 2 clinical trial to examine the effects of razuprotafib on COVID-19 patients

Researchers at the University of Cincinnati and UC Health will host a Phase 2 clinical trial (NCT04511650) to examine the effects of a drug that targets blood vessel inflammation and injury in patients with COVID-19.

22 Sep 2020

Targeted treatment for systemic lupus erythematosus

A team of researchers from Charité - Universitätsmedizin Berlin and the Deutsches Rheuma-Forschungszentrum Berlin, a Leibniz Institute, have successfully treated two patients with the autoimmune disease systemic lupus erythematosus.

22 Sep 2020

Parkinson's disease diagnosed after SARS-CoV-2

As the COVID-19 pandemic continues to spread, new and unusual chronic sequelae of the disease are cropping up in many medical practices. Now, a new case paper published in The Lancet in September 2020 describes a case of new-onset Parkinson's disease following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

22 Sep 2020

Exercise hormone could have a therapeutic effect on COVID-19 patients

A study conducted by researchers at São Paulo State University suggests that irisin, a hormone secreted from muscles in response to exercise, could have a therapeutic effect on COVID-19 patients.

22 Sep 2020

Research consortium receives $111 million NCI grant to prevent, treat HIV-related cancers

The widespread use of antiretroviral therapy to suppress the HIV virus has helped tens of millions of people with HIV live healthier, longer lives--but an unfortunate consequence of people living longer with HIV is an increased risk of cancer.

22 Sep 2020

Researchers identify a potential drug candidate for hand, foot and mouth disease

A study appearing next week in the journal Nature Communications offers some good news in the search for antiviral drugs for hard-to-treat diseases. Researchers have identified a potential new drug candidate against enterovirus 71, a common cause of hand, foot and mouth disease in infants and young children

22 Sep 2020

Diabetes leads to drastic reduction in the kidney's potential to clean itself

The kidneys often become bulky and dysfunctional in diabetes, and now scientists have found that one path to this damage dramatically reduces the kidney's ability to clean up after itself.

22 Sep 2020

Study detects key differences in immune responses of adults and children with COVID-19

The first study comparing the immune responses of adults and children with COVID-19 has detected key differences that may contribute to understanding why children usually have milder disease than adults.

22 Sep 2020

Study finds cardiac involvement in MIS-C is associated with myocardial injury

Using sensitive parameters to assess cardiac function, researchers at Children's Hospital of Philadelphia (CHOP) have found that cardiac involvement in multisystem inflammatory syndrome in children (MIS-C) differs from Kawasaki disease (KD) and is associated with myocardial injury.

21 Sep 2020

BU researchers find how SARS-CoV-2 infection may drive deadly lung inflammation

Responding to the COVID-19 pandemic caused by the novel coronavirus, SARS-CoV-2, requires models that can duplicate disease development in humans, identify potential targets and enable drug testing.

21 Sep 2020

New discovery of an interaction between sensory neurons and immune cells

Pain is a protective mechanism, alerting us to danger by generating an unpleasant sensation. The warning message is carried to the spinal cord by specialized sensory neurons, which are intertwined with other sensory and motor neurons in peripheral nerves.

21 Sep 2020

Using computer simulations to examine personalized mechanical ventilation of COVID-19 patients

Initial clinical guidelines for mechanical ventilation of COVID-19 patients suggested following standard approaches used in the treatment of acute respiratory distress syndrome (ARDS), which is characterized by rapid onset of widespread inflammation in the lungs.

21 Sep 2020

Psoriatic arthritis may be activated by the same trigger in different patients, study reveals

A new study has revealed psoriatic arthritis may be activated by the same trigger in different patients. Researchers from the University of Oxford and the Wellcome Sanger Institute identified high levels of a specific receptor in immune cells from psoriatic arthritis patients, giving the strongest evidence yet of a single cause for the disease

21 Sep 2020

Rheumatoid arthritis is associated with increased risk of developing diabetes

A new study presented at this year's annual meeting of the European Association for the Study of Diabetes (EASD), held online this year, shows that rheumatoid arthritis (RA) is associated with a 23% increased risk of type 2 diabetes (T2D), and may indicate that both diseases are linked to the body's inflammatory response.

21 Sep 2020

Stroke patients with COVID-19 have increased systemic inflammation, higher mortality risk

Stroke patients who also have COVID-19 showed increased systemic inflammation, a more serious stroke severity and a much higher rate of death, compared to stroke patients who did not have COVID-19, according to University of Alabama at Birmingham research led by Chen Lin, M.D., an assistant professor in the UAB Department of Neurology.

19 Sep 2020

Scientists identify new drug to prevent SARS-CoV-2 infection consequences

Scientists from the Department of Cell Biology of the University of Malaga and the Andalusian Centre for Nanomedicine and Biotechnology have made progress in finding new rapid implementation therapies to combat the COVID-19 pandemic, identifying a new drug that could prevent or mitigate the consequences derived from SARS-CoV-2 infection.

19 Sep 2020

Inflammation News and Research

HIV drugs cause immune-system changes that can improve resistance to viral infections

Black young adults pay a higher price to achieve prosperity

Baseline T cell signatures predict clinical outcomes of SARS-CoV infection

Research explains why flu is dangerous for pregnant women

Phase 2 clinical trial to examine the effects of razuprotafib on COVID-19 patients

Targeted treatment for systemic lupus erythematosus

Parkinson's disease diagnosed after SARS-CoV-2

Exercise hormone could have a therapeutic effect on COVID-19 patients

Research consortium receives $111 million NCI grant to prevent, treat HIV-related cancers

Researchers identify a potential drug candidate for hand, foot and mouth disease

Diabetes leads to drastic reduction in the kidney's potential to clean itself

Study detects key differences in immune responses of adults and children with COVID-19

Study finds cardiac involvement in MIS-C is associated with myocardial injury

BU researchers find how SARS-CoV-2 infection may drive deadly lung inflammation

New discovery of an interaction between sensory neurons and immune cells

Using computer simulations to examine personalized mechanical ventilation of COVID-19 patients

Psoriatic arthritis may be activated by the same trigger in different patients, study reveals

Rheumatoid arthritis is associated with increased risk of developing diabetes

Stroke patients with COVID-19 have increased systemic inflammation, higher mortality risk

Scientists identify new drug to prevent SARS-CoV-2 infection consequences

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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