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Medical steroid use could push up diabetes risk

Glucocorticoids (GCs), or steroids, as they are popularly called, are often prescribed for their anti-inflammatory effects in a host of conditions including acute asthmatic attacks, allergies, and arthritis. However, are they doing good or harm?

12 Nov 2019

Contraceptive drug effective in preventing and regressing cervical cancer in mice

A new study in The American Journal of Pathology, published by Elsevier, reports that medroxyprogesterone acetate (MPA), the active ingredient in the common contraceptive injection Depo-Provera, was effective in preventing the development of cervical cancer in mice with precancerous lesions.

12 Nov 2019

Juvenile immune arthritis – new treatments wanted

Juvenile immune arthritis (JIA) is a severely undertreated condition, and new medications are badly needed to relieve the signs and symptoms of the illness, according to a new study presented at the 2019 ACR/ARP Annual Meeting.

11 Nov 2019

New textbook on mysterious and deadly cytokine storm syndrome

There's no telling where the call will come from, or when. But Randy Cron, M.D., Ph.D., professor of pediatrics and medicine at UAB, knows to expect them.

11 Nov 2019

Study shows how glucocorticoid hormones control sugar and fat levels over the course of 24 hours

For the first time, a study led by researchers at Helmholtz Zentrum München and the German Center for Diabetes Research shows how glucocorticoid hormones, such as cortisol, control sugar and fat levels differently during day and night, feeding and fasting, rest and activity, over the course of 24 hours.

10 Nov 2019

Scientists discover role for vitamin D in melanoma

A new study published in Cancer Research suggests that high levels of vitamin D may reduce the aggressive nature of melanoma cells and improve survival rates.

8 Nov 2019

Vitamin D and omega-3 fatty acids are not effective at reducing systemic inflammation

Vitamin D and marine omega-3 fatty acids -- also known as fish oil -- are purported to have many health benefits, including reducing systemic inflammation.

7 Nov 2019

Study uncovers how cells 'forget their past' while developing into a specific cell

All cells in the body contain the same genetic material. The difference between cells therefore depends solely on which genes are expressed or ‘turned on’.

7 Nov 2019

Experimental drug targets currently untreatable type of lung cancer

Scientists at Stanford and UC-San Francisco have developed an experimental drug that targets a currently untreatable type of lung cancer responsible for generating roughly 500,000 newly diagnosed cases worldwide each year.

7 Nov 2019

Researchers discover new process of antitumor response of NK cells in myeloma

NK cells mean Natural Killer cells. They are part of the innate immune system. They are known primarily for their ability to recognize and kill tumor cells, cells infected by viruses and bacteria, or dying by apoptosis. Although evidence about their antitumoral capacity, how this activity occurred remained unknown.

5 Nov 2019

Researchers successfully treat pain using nanoparticles to deliver a non-opioid medication

The use of nanoparticles to deliver a drug into specific nerve cells has resulted in significantly improved pain relief.

5 Nov 2019

MD Anderson and Takeda announce agreement to develop off-the-shelf CAR NK-cell therapy platform

The University of Texas MD Anderson Cancer Center and Takeda Pharmaceutical Company Limited today announced an exclusive license agreement and research agreement to develop cord blood-derived chimeric antigen receptor-directed natural killer (CAR NK)-cell therapies, 'armored' with IL-15, for the treatment of B-cell malignancies and other cancers.

5 Nov 2019

Researchers produce synthetic phages that attack broader range of bacterial strains

Bacteriophages ("phages" for short) are viruses that infect bacteria. Phages are highly host-specific and will typically only infect and kill an individual species or even subspecies of bacteria. Compared to conventional antibiotics, phages do not indiscriminately kill bacteria.

4 Nov 2019

Researchers develop new type of transposase protein with improved biochemical properties

The team, comprising researchers from the European Molecular Biology Laboratory, the Universitätsklinikum Würzburg and the Paul-Ehrlich-Institut, managed to design a new variant of the Sleeping Beauty transposase with dramatically improved biochemical properties.

4 Nov 2019

Nanoparticle drug delivery enhances and prolongs pain relief in animal models

An international team of researchers has used nanoparticles to deliver a drug- one that previously failed in clinical trials for pain- into specific compartments of nerve cells, dramatically increasing its ability to treat pain in mice and rats.

4 Nov 2019

How venom from marine cone snails can be used in pain therapy

Conotoxins are bioactive peptides found in the venom that marine cone snails produce for prey capture and defense.

4 Nov 2019

New study may help better understand mechanisms that control blood pressure

Many questions remain about the mechanisms that control blood pressure, particularly in relation to hypertension.

1 Nov 2019

Correlates of HIV risk associated with decrease in disease transmission, study confirms

Immune responses that are associated with a decreased risk of infection are called correlates of protection.

1 Nov 2019

Discovery of human cell signaling systems using bioinformatics

There are many and various receptors on the surface of each human cell, which bind to specific molecules called ligands, to set off signals that modulate cell activity accordingly. These pathways are exploited by therapeutic drugs. In fact, one in three drugs makes use of receptors belonging to a single very large family – the GPCR (G protein receptor coupled receptor) family.

1 Nov 2019

UCLA prostate cancer program receives $8.7 million grant from NCI

The prostate cancer program at the UCLA Jonsson Comprehensive Cancer Center and UCLA Health has been awarded an $8.7 million Specialized Program of Research Excellence, or SPORE, grant from the National Cancer Institute.

31 Oct 2019

Receptor News and Research

Medical steroid use could push up diabetes risk

Contraceptive drug effective in preventing and regressing cervical cancer in mice

Juvenile immune arthritis – new treatments wanted

New textbook on mysterious and deadly cytokine storm syndrome

Study shows how glucocorticoid hormones control sugar and fat levels over the course of 24 hours

Scientists discover role for vitamin D in melanoma

Vitamin D and omega-3 fatty acids are not effective at reducing systemic inflammation

Study uncovers how cells 'forget their past' while developing into a specific cell

Experimental drug targets currently untreatable type of lung cancer

Researchers discover new process of antitumor response of NK cells in myeloma

Researchers successfully treat pain using nanoparticles to deliver a non-opioid medication

MD Anderson and Takeda announce agreement to develop off-the-shelf CAR NK-cell therapy platform

Researchers produce synthetic phages that attack broader range of bacterial strains

Researchers develop new type of transposase protein with improved biochemical properties

Nanoparticle drug delivery enhances and prolongs pain relief in animal models

How venom from marine cone snails can be used in pain therapy

New study may help better understand mechanisms that control blood pressure

Correlates of HIV risk associated with decrease in disease transmission, study confirms

Discovery of human cell signaling systems using bioinformatics

UCLA prostate cancer program receives $8.7 million grant from NCI

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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