Epidemiology News and Research

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Smoke-free workplace laws help reduce heart attacks and save lives

Mayo Clinic researchers have amassed additional evidence that secondhand smoke kills and smoke-free workplace laws save lives.

14 Nov 2011

Sugary drinks raise risk of heart disease in women: Study

A new study shows that women who take sugared beverages every day may be raising their risk for heart disease, even if their habit is not packing on the pounds. The researchers say the drinks could be anything - sweet tea, soda, or coffee drinks that look like desserts.

14 Nov 2011

Great Basin seeks FDA 510(k) approval for C. difficile molecular diagnostic test

Great Basin Corporation, a privately held life sciences company developing sample-to-result molecular diagnostic solutions, today announced it has submitted a 510(k) application to the U.S. Food and Drug Administration (FDA) for its first molecular diagnostic test for Clostridium difficile (C. diff).

14 Nov 2011

Scientists create new phenotypic cancer drug screening platform

Researchers have created a new phenotypic screening platform that better predicts success of drugs developed to prevent blood vessel tumor growth when moving out of the lab and onto actual tumors.

14 Nov 2011

Scientists identify factors that lead to concomitant tumor resistance

Scientists are another step closer to understanding what drives tumor metastasis, as laboratory models suggest there are factors inside tumors that can slow their own growth.

14 Nov 2011

Next-generation drugs may prevent skin lesions in BRAF mutation-positive melanoma

Findings from preclinical studies in a skin cancer model showed that next-generation BRAF inhibitors used alone, or first-generation BRAF inhibitors used in combination with an epidermal growth factor receptor inhibitor, may have the potential to prevent drug-induced skin lesions in BRAF mutation-positive patients treated for melanoma.

14 Nov 2011

Combination of REGN910 and aflibercept inhibits tumor angiogenesis in animal models

Combining the investigational agents REGN910 and aflibercept yielded statistically significant improvements in antitumor effects in animal models compared with either agent alone, according to results presented at the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics, held Nov. 12-16, 2011.

14 Nov 2011

Amplification of ALK gene may drive rapid breast cancer metastasis

Amplification of anaplastic lymphoma kinase, which has been reported in other cancers such as non-small cell lung cancers, may be a primary driver of the rapid metastasis that patients with inflammatory breast cancer experience.

14 Nov 2011

Researchers show how ER-positive breast cancer tumors become resistant to tamoxifen

Researchers have shown how estrogen receptor-positive breast cancer tumors become resistant to tamoxifen, the only approved hormonal therapy for premenopausal patients with this type of breast cancer.

14 Nov 2011

Patients with KRAS mutant NSCLC should respond well to antifolates

Patients with non-small cell lung cancer who have mutations in the KRAS gene should respond well to the antifolate class of drugs, according to results of a recent study conducted by Quintiles comparing human lung cancer cell lines and patients.

14 Nov 2011

Intensive therapy can preserve kidney function in patients with type 1 diabetes

People with type 1 diabetes are at high risk of developing kidney disease, but no therapies are proven to prevent impaired kidney function in these patients. In the Diabetes Control and Complications Trial (DCCT), Ian de Boer, MD and his team looked to see if intensive diabetes therapy aimed at reducing blood sugar as close to the normal range as possible might protect type 1 diabetics' kidney function. The study's results were presented during the American Society of Nephrology's Annual Kidney Week.

14 Nov 2011

Maintaining normal blood glucose levels prevents long-term kidney complications

Maintaining good glucose control early in the course of type 1 diabetes could lessen the long-term risk of kidney disease, as measured by a common test of kidney function.

14 Nov 2011

Cedars Sinai researcher to receive American Heart Association-Philips Resuscitation Fellowship Award

Royal Philips Electronics today announced that Dr. Carmen Teodorescu, M.D., Ph.D., a post-doctoral fellow at The Heart Institute at Cedars Sinai Medical Center in Los Angeles, California was selected as the recipient of the fifth annual American Heart Association-Philips Resuscitation Fellowship Award.

14 Nov 2011

Depression linked to heart disease mortality among young people

The negative effects of depression in young people on the health of their hearts may be stronger than previously recognized. Depression or a history of suicide attempts in people younger than 40, especially young women, markedly increases their risk for dying from heart disease, results from a nationwide study have revealed.

14 Nov 2011

UM to host Summit on Childhood Obesity at Hilton Baltimore

Science and medical reporters are invited to sample a wide diversity of new research and policy initiatives at a Summit on Childhood Obesity on Tues., Nov. 15 and Wed., Nov. 16 at the Hilton Baltimore.

13 Nov 2011

IVI receives WHO prequalification for new oral cholera vaccine

Shanchol-, a new oral cholera vaccine developed through the International Vaccine Institute (IVI), an international organization established by the United Nations and based in Seoul, recently received prequalification from the World Health Organization.

13 Nov 2011

Unfavorable fetal development affects physical functioning at the age of 60 years

Low birth weight and slow growth progressing to greater body mass in pre-adolescence significantly increased the risk of poor physical functioning at the age of 60 years, a new Finnish study published in the American Journal of Epidemiology found.

11 Nov 2011

Vaccination dramatically reduces incidence of Hib disease in young children

Vaccination against Haemophilus influenzae type b, or Hib, once the most common cause of bacterial meningitis in children, has dramatically reduced the incidence of Hib disease in young children over the past 20 years, according to a study published in Clinical Infectious Diseases and available online.

11 Nov 2011

Johns Hopkins to establish new global center for childhood obesity

The Johns Hopkins Bloomberg School of Public Health has been awarded a $16 million U54 cooperative agreement from the National Institutes of Health (NIH) to establish a global center of excellence to address the childhood obesity epidemic.

11 Nov 2011

Alcohol consumption may decrease risk of death from coronary artery disease

In a prospective, observational study of approximately 150,000 Norwegians, the investigators found that alcohol consumption was associated with a large decrease in the risk of death from coronary artery disease.

11 Nov 2011