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Researchers complete phase II clinical trial of dasatinib for patients with higher-risk MDS

Researchers at Moffitt Cancer Center have completed a phase II clinical trial to determine the safety and efficacy of dasatinib for patients with higher-risk myelodysplastic syndromes, chronic myelomonocytic leukemia, or acute myeloid leukemia resulting from MDS and have failed treatment with azanucleosides.

21 Mar 2013

Cedars-Sinai surgeons perform more adult heart transplants in 2012, statistics show

For the third year in a row, the Cedars-Sinai Heart Institute and Comprehensive Transplant Center performed more adult heart transplants than any other U.S. medical center, according to statistics compiled by the United Network for Organ Sharing, the nonprofit organization that manages the nation's transplant system.

21 Mar 2013

Genetically modified tomatoes mimic actions of good cholesterol

UCLA researchers have genetically engineered tomatoes to produce a peptide that mimics the actions of good cholesterol when consumed.

20 Mar 2013

Illinois chemists use DNA catalysts to do protein's job

Illinois chemists have used DNA to do a protein's job, creating opportunities for DNA to find work in more areas of biology, chemistry and medicine than ever before.

20 Mar 2013

Research reveals immortality gene mutation plays pivotal role in brain tumors, other cancers

Newly identified mutations in a gene that makes cells immortal appear to play a pivotal role in three of the most common types of brain tumors, as well as cancers of the liver, tongue and urinary tract, according to research led by Duke Cancer Institute.

19 Mar 2013

New study may help develop targeted therapies for controlling tissue destruction

Stroke, heart attacks and numerous other common disorders result in a massive destruction of cells and tissues called necrosis. It's a violent event: As each cell dies, its membrane ruptures, releasing substances that trigger inflammation, which in turn can cause more cellular necrosis.

19 Mar 2013

Umbilical cord blood stem cell transplants may be an effective alternative to treat Hurler's syndrome

Transplants of blood-forming stem cells from umbilical cord blood may be an effective alternative to transplants of matched donor bone marrow stem cells to treat children with a rare, debilitating disease known as Hurler's syndrome (HS), according to results of a study published online today in Blood, the Journal of the American Society of Hematology (ASH).

17 Mar 2013

New molecular sensor technique for cancer therapy detects lactate levels in individual cells

Cancer cells break down sugars and produce the metabolic acid lactate at a much higher rate than normal cells. This phenomenon provides a telltale sign that cancer is present, via diagnostics such as PET scans, and possibly offers an avenue for novel cancer therapies.

16 Mar 2013

Researchers identifiy elusive anti-cancer property of vitamin E

Researchers have identified an elusive anti-cancer property of vitamin E that has long been presumed to exist, but difficult to find. Many animal studies have suggested that vitamin E could prevent cancer, but human clinical trials following up on those findings have not shown the same benefits.

16 Mar 2013

Luminex collaborates with Merck to design companion diagnostic device for Alzheimer’s disease

WHITEHOUSE STATION known as MSD outside the United States and Canada, and Luminex Corporation have signed a collaboration and license agreement to develop a companion diagnostic device that will be evaluated to help screen patients for recruitment into Merck's clinical development program for MK-8931, a novel oral beta amyloid precursor protein site cleaving enzyme (BACE) inhibitor and Merck's lead investigational candidate for Alzheimer's disease (AD).

From Luminex 15 Mar 2013

Researchers identify enzymes that activate coronavirus for infection

Scientists all over the world are on a quest for an antidote since the first patient died from the new coronavirus in summer 2012. Infection Researchers from the German Primate Center have now identified enzymes that activate the virus for infection.

15 Mar 2013

Lighthouse project focuses on regenerative medicine

A German research team led by Professor Dr. Werner E. G. M-ller of the Institute of Physiological Chemistry at the University Medical Center of Johannes Gutenberg University Mainz (JGU) and scientists from the Chinese Academy of Sciences and the Chinese Academy of Geological Sciences have launched a Chinese-German Joint Center for Bio-Inspired Materials.

14 Mar 2013

Trial evaluates ranolazine in patients with diabetes, coronary artery disease and angina

A commonly used anti-anginal drug reduces chest pain in patients with type 2 diabetes and appears to have a more pronounced effect in those with poorer glucose control, according to research presented today at the American College of Cardiology's 62nd Annual Scientific Session.

13 Mar 2013

ADP-ribose plays key role in repairing cellular DNA damage

Attaching chains of the small molecule ADP-ribose to proteins is important for a cell's survival and the repair of DNA damage, making this process a promising target for the development of new cancer drugs.

13 Mar 2013

Bitter melon juice restricts ability of pancreatic cancer cells to metabolize glucose

A University of Colorado Cancer study published this week in the journal Carcinogenesis shows that bitter melon juice restricts the ability of pancreatic cancer cells to metabolize glucose, thus cutting the cells' energy source and eventually killing them.

13 Mar 2013

Aliskiren and standard therapy not associated with reduced CV death or HF rehospitalization

Among patients hospitalized for heart failure (HF) with reduced left ventricular ejection fraction (LVEF; a measure of how well the left ventricle of the heart pumps with each contraction), initiation of the medication aliskiren in addition to standard therapy did not reduce cardiovascular death or HF rehospitalization at 6 or 12 months after discharge, according to a study published online by JAMA.

12 Mar 2013

Lack of very long chain fatty acids does not cause blindness in children with Stargardt type 3

Vision scientists long have thought that lack of very long chain fatty acids in photoreceptor cells caused blindness in children with Stargardt type 3 retinal degeneration, an incurable eye disease. But researchers at the University of Utah's John A. Moran Eye Center have shown in a new study that lack of these fatty acids does not cause blindness, meaning that the search for the mechanism that robs sight from children with the disease must start anew.

12 Mar 2013

Armetheon plans to develop tecarfarin against prosthetic heart valves or chronic renal dysfunction

Armetheon, Inc., a clinical stage biopharmaceutical company, announced today that it plans to develop its novel oral anti-coagulant (OAC), tecarfarin (ATI-5923), for a patient population which includes those who have prosthetic heart valves or chronic renal dysfunction.

11 Mar 2013

Researchers identify enzymes that can regulate activity of medically important proteins

Protein activity is strictly regulated. Incorrect or poor protein regulation can lead to uncontrolled growth and thus cancer or chronic inflammation. Members of the Institute of Veterinary Biochemistry and Molecular Biology from the University of Zurich have identified enzymes that can regulate the activity of medically important proteins.

11 Mar 2013

Drugs that combat ageing may be available within five years

Drugs that combat ageing may be available within five years, following landmark work led by an Australian researcher.

11 Mar 2013

Enzyme News and Research

Researchers complete phase II clinical trial of dasatinib for patients with higher-risk MDS

Cedars-Sinai surgeons perform more adult heart transplants in 2012, statistics show

Genetically modified tomatoes mimic actions of good cholesterol

Illinois chemists use DNA catalysts to do protein's job

Research reveals immortality gene mutation plays pivotal role in brain tumors, other cancers

New study may help develop targeted therapies for controlling tissue destruction

Umbilical cord blood stem cell transplants may be an effective alternative to treat Hurler's syndrome

New molecular sensor technique for cancer therapy detects lactate levels in individual cells

Researchers identifiy elusive anti-cancer property of vitamin E

Luminex collaborates with Merck to design companion diagnostic device for Alzheimer’s disease

Researchers identify enzymes that activate coronavirus for infection

Lighthouse project focuses on regenerative medicine

Trial evaluates ranolazine in patients with diabetes, coronary artery disease and angina

ADP-ribose plays key role in repairing cellular DNA damage

Bitter melon juice restricts ability of pancreatic cancer cells to metabolize glucose

Aliskiren and standard therapy not associated with reduced CV death or HF rehospitalization

Lack of very long chain fatty acids does not cause blindness in children with Stargardt type 3

Armetheon plans to develop tecarfarin against prosthetic heart valves or chronic renal dysfunction

Researchers identify enzymes that can regulate activity of medically important proteins

Drugs that combat ageing may be available within five years

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