Crystallography News and Research

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Radically different approach to nuclear magnetic resonance

Detecting the molecular structure of a tiny protein using nuclear magnetic resonance (NMR) currently requires two things: a million-dollar machine the size of a massive SUV, and a large sample of the protein under study.

16 May 2007

Scientists find new way to analyze the moving parts of large proteins

Scientists from Baylor College of Medicine (BCM) and Rice University have discovered a new way to analyze the moving parts of large proteins , a breakthrough that will make it easier for structural biologists to classify and scrutinize the active sites of proteins implicated in cancer and other diseases.

1 May 2007

Purdue molecule could lead to first drug treatment for Alzheimer's disease

A molecule designed by a Purdue University researcher could lead to the first drug treatment for Alzheimer's disease.

18 Apr 2007

What makes a simple biological clock tick?

An interdisciplinary team of researchers at Vanderbilt University has analyzed the simplest known biological clock and figured out what makes it tick.

3 Apr 2007

New drug target for herpes viruses

Scientists in the lab of Whitehead Institute Member Hidde Ploegh and the Harvard University lab of Rachelle Gaudet have solved the complex structure of a recently discovered protein that is found in a wide range of herpes viruses. This protein may prove to be a potential drug target.

11 Mar 2007

New drug target for herpes viruses

11 Mar 2007

Scientists visualize influenza virus particles

Scientists at the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), and colleagues at the University of Virginia in Charlottesville have succeeded in imaging, in unprecedented detail, the virus that causes influenza.

2 Jan 2007

Flexible interface between DNA ligase and a heterotrimeric sliding clamp supports conformational switching and efficient ligation of DNA

Scientists investigating an important DNA-repair enzyme now have a better picture of the final steps of a process that glues together, or ligates, the ends of DNA strands to restore the double helix.

20 Oct 2006

Phase separation of lipid membranes analyzed with high-resolution secondary ion mass spectrometry

Understanding the chemical composition and organization of cell membranes - what components reside next to each other, how many of each there are and how they respond to their environment - may reveal the secret lives of cells in both health and disease.

9 Oct 2006

First step to developing effective therapy against Venezuelan Equine Encephalitis virus

Biomedical researchers at the University of Texas Medical Branch at Galveston (UTMB) have taken an important early step toward developing effective drug therapies against Venezuelan Equine Encephalitis (VEE) virus, a potential bioterrorist weapon.

12 Sep 2006

Researchers determine structure of an important smallpox virus enzyme and how it binds to DNA

Researchers at the University of Pennsylvania School of Medicine have determined the structure of an important smallpox virus enzyme and how it binds to DNA.

4 Aug 2006

Darunavir - first molecule to treat drug-resistant HIV

Doctors have their first FDA-approved tool to treat drug-resistant HIV thanks to a new molecule created by a Purdue University researcher.

2 Aug 2006

Which came first, nucleic acids or proteins?

Which came first, nucleic acids or proteins? This question is molecular biology's version of the "chicken-or-the-egg" riddle.

24 Jul 2006

3D map of the structure of the enzyme D-xylose isomerase

An innovative collaboration among scientists at Los Alamos National Laboratory, Fox Chase Cancer Center and the University of Tennessee has successfully applied neutron diffraction to create a three-dimensional map of the structure of the enzyme D-xylose isomerase.

16 May 2006

Scientists learn valuable lesson from nature - secret behind nature's medicines

After years of wondering how organisms managed to create self-medications, such as anti-fungal agents, chemists have discovered the simple secret.

3 May 2006

Research into toxins points to development of better medicines

Researchers have combined magnetic resonance spectroscopy with special protein synthesis procedures to uncover how potassium channels and toxins combine and change in structure. This work could make it possible to develop medications for high blood pressure and many other diseases connected to potassium channel failure .

23 Apr 2006