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Novel PF74 molecule effectively targets HIV capsid protein

Of all known small molecules targeting human immunodeficiency virus (HIV) capsid protein (CA), PF74 represents by far the best characterized chemotype, due to its ability to confer antiviral phenotypes in both early and late phases of viral replication.

9 Apr 2021

Oxford-AstraZeneca COVID vaccine induces cell spikes similar to SARS-CoV-2's

Scientists from the University of Oxford and the University of Southampton report in the journal ACS Central Science that cells infected with the ChAdOx1 vaccine produce spike proteins on the cells similar to those produced by natural SARS-CoV-2 infection.

9 Apr 2021

Prefusion SARS-CoV-2 spike-based vaccine candidate shows high safety and efficacy in phase I trial

A new preprint research paper posted to the medRxiv server reports the results of the first human trial of the prefusion stabilized SARS-CoV-2 spike vaccine MVC-COV1901 in Taiwan.

8 Apr 2021

NIH-funded clinical trial begins study of systemic allergic reactions to COVID-19 vaccines

A clinical trial is underway to determine whether people who are highly allergic or have a mast cell disorder are at increased risk for an immediate, systemic allergic reaction to the Moderna or Pfizer-BioNTech COVID-19 vaccines.

7 Apr 2021

Researchers determine key protein structure that may lead to effective treatments for schizophrenia

Glycine is the smallest amino acid - one of the building blocks of proteins. It acts also as a neurotransmitter in the brain, enabling neurons to communicate with each other and modulating neuronal activity.

7 Apr 2021

Scientists use cryo-electron microscopy to unravel how 'guardian' of the genome works

Scientists from the Genomic Integrity and Structural Biology Group led by Rafael Fernández-Leiro at the Spanish National Cancer Research Centre have discovered how certain proteins ensure the repair of errors introduced into the DNA during its replication.

6 Apr 2021

Researchers use single-cell RNA sequencing technologies to track cellular development in leaves

While developmental biologists have long researched this fundamental question, Stanford University biologist and HHMI investigator Dominique Bergmann's recent work on the plant Arabidopsis thaliana has uncovered surprising answers.

5 Apr 2021

The use of mammalian cell surface display for rapid characterization of SARS-CoV-2 variants

A research group from the U.S. demonstrated the practicality of a spike display system in order to accelerate vaccine design, but also to swiftly appraise the effects of mutations in emerging strains of the SARS-CoV-2.

5 Apr 2021

Russian researchers develop a safe, inexpensive packed eggs surface disinfection technology

Russian researchers have developed an inexpensive, safe, and reliable packed eggs surface disinfection technology.

3 Apr 2021

Researchers provide experimental evidence for synaptic plasticity in the human brain

Neuroscientists agree that a person's brain is constantly changing, rewiring itself and adapting to environmental stimuli.

31 Mar 2021

New mRNA COVID-19 vaccine candidate shows promise in vivo

Researchers report that a new lipid nanoparticle mRNA coronavirus disease 2019 (COVID-19) vaccine candidate protected 70% of mice expressing the human angiotensin-converting enzyme 2 (ACE2), while all the non-vaccinated mice died.

31 Mar 2021

Soft X-ray microscopy shows how viral pathogens penetrate human cells

How do viral pathogens succeed in penetrating human cells? Which cellular mechanisms do they use to multiply efficiently and, in doing so, how do they change the structure of their host cell? These questions are the focus of a pan-European research project called "Compact Cell-Imaging Device" (CoCID), in which Heidelberg scientists are playing a major role.

31 Mar 2021

NIAID researchers identify key player in the immune response to SARS-CoV-2

When variants of SARS-CoV-2 (the virus that causes COVID-19) emerged in late 2020, concern arose that they might elude protective immune responses generated by prior infection or vaccination, potentially making re-infection more likely or vaccination less effective.

31 Mar 2021

Study shows how viral distribution of SARS-CoV-2 in the human body relates to tissue damage

Researchers have mapped the distribution of SARS-CoV-2, the virus that causes COVID-19, in deceased patients with the disease, and shed new light on how viral load relates to tissue damage.

31 Mar 2021

Nanoparticles elicit neutralizing antibodies to diverse SARS-CoV-2 variants

Spike-protein-based nanoparticle vaccine candidates were retained longer in follicular dendritic cells and showed higher germinal center reactions in lymph node follicles compared to soluble spike protein vaccine.

30 Mar 2021

Study reveals the structure of key enzyme that may advance cancer research

In order to develop more effective drugs against a range of cancers, researchers have been investigating the molecular structure of many diseased-linked enzymes in the body. An intriguing case in point is Taspase 1, a type of enzyme known as a protease.

30 Mar 2021

HSV-1 infection induces strain-specific transcriptional differences in infected neurons

Why do some people with cold sores around their lips experience painful lesions, while others have no symptoms at all, yet still spread the virus? A new study conducted at Penn State finds that these differences could be due to variations in the way certain strains of herpes simplex (HSV-1) -- the virus that causes cold sores, as well as genital herpes -- activate gene expression in neurons.

29 Mar 2021

Electron News and Research

Novel PF74 molecule effectively targets HIV capsid protein

Oxford-AstraZeneca COVID vaccine induces cell spikes similar to SARS-CoV-2's

Prefusion SARS-CoV-2 spike-based vaccine candidate shows high safety and efficacy in phase I trial

NIH-funded clinical trial begins study of systemic allergic reactions to COVID-19 vaccines

Researchers determine key protein structure that may lead to effective treatments for schizophrenia

Scientists use cryo-electron microscopy to unravel how 'guardian' of the genome works

Researchers use single-cell RNA sequencing technologies to track cellular development in leaves

The use of mammalian cell surface display for rapid characterization of SARS-CoV-2 variants

Russian researchers develop a safe, inexpensive packed eggs surface disinfection technology

Researchers provide experimental evidence for synaptic plasticity in the human brain

New mRNA COVID-19 vaccine candidate shows promise in vivo

Soft X-ray microscopy shows how viral pathogens penetrate human cells

NIAID researchers identify key player in the immune response to SARS-CoV-2

Study shows how viral distribution of SARS-CoV-2 in the human body relates to tissue damage

Nanoparticles elicit neutralizing antibodies to diverse SARS-CoV-2 variants

Study reveals the structure of key enzyme that may advance cancer research

HSV-1 infection induces strain-specific transcriptional differences in infected neurons

Environmentally persistent free radicals found in wildfire charcoals remain stable for years

Research sheds light on a new neuroprotective mechanism to control damage following brain injury

Drugging RNA synthesis in SARS-CoV-2 as novel therapeutic avenue

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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