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New review explains how circular RNAs could unlock fat browning therapies

A Cell Death & Disease review synthesizes preclinical evidence that circular RNAs regulate adipose browning and metabolic pathways through microRNA interactions, protein binding, and organelle-linked stress mechanisms. It highlights their biomarker and therapeutic potential in obesity and type 2 diabetes while underscoring key translational challenges, including delivery specificity and human validation.

26 Feb 2026

Serial liquid biopsies reveal evolution in advanced prostate cancer

A new study using serial liquid biopsies to track how metastatic prostate cancer evolves under treatment pressure showed that androgen receptor (AR) alterations consistently emerged and were linked to poorer outcomes across therapies.

26 Feb 2026

Extra copies of chromosome 1q may play key role in the earliest stages of pancreatic cancer

Researchers at the Johns Hopkins Kimmel Cancer Center and its Ludwig Center uncovered new evidence that extra copies of a specific chromosome segment - chromosome 1q - may play a key role in the earliest stages of pancreatic cancer development.

26 Feb 2026

Smoking triggers epigenetic damage linked to macular degeneration

Through a series of experiments supported by the National Institutes of Health, Johns Hopkins Medicine (JHM) researchers say they have advanced understanding of how smoking damages the eye and contributes to the development of age-related macular degeneration (AMD), the leading worldwide cause of visual impairment and blindness among people 50 and older.

26 Feb 2026

New method clarifies whether NOTCH1 variants cause congenital heart defects

One to two out of every 100 newborn babies are born with a Congenital Heart Defect (CHD), yet the exact cause remains unclear.

26 Feb 2026

Genetic switch MafB enables macrophages to reach full maturity and preserve organ health

Researchers at the University of Liège have identified a key genetic regulator that enables macrophages to reach full maturity and preserve the health of our organs.

26 Feb 2026

Researchers reveal why SuperAgers retain youthful brain cell signatures into their 80s

Researchers used single-nucleus RNA sequencing and chromatin accessibility profiling to map human hippocampal neurogenesis across adulthood, aging, and Alzheimer’s disease. They found that chromatin accessibility changes, more than gene expression alone, distinguish healthy aging, preclinical pathology, Alzheimer’s disease, and cognitive resilience in SuperAgers.

26 Feb 2026

Neanderthal DNA loss tied to ancient interbreeding dynamics

The human genome is a rich, complex record of migration, encounters, and inheritance written over thousands of millennia.

26 Feb 2026

Jumping DNA fragments found to destabilize cancer genome

A study published today in the journal Science reveals how jumping fragments of human DNA, a type of genetic parasite, destabilise the cancer genome. Unstable genomes are a fertile playground for cancer evolution, giving malignant cells more opportunities to grow, adapt and evade treatment.

26 Feb 2026

New mouse model uncovers achondroplasia's cellular growth plate dysregulation

Achondroplasia, also known as short-limb dwarfism, is associated with neurological symptoms and complications due to narrowing of the skeletal structures surrounding the spinal cord.

26 Feb 2026

Microbial cities in space: Risks and opportunities for astronauts

A global team of scientists has identified an often-overlooked biological system - biofilms - as a critical factor in the future of human space exploration.

26 Feb 2026

Reducing miRNA levels helps rescue vascular defects in Rett syndrome

MIT researchers have discovered that two common genetic mutations that cause Rett syndrome each set off a molecular chain of events that compromises the structural integrity of developing brain blood vessels, making them leaky.

25 Feb 2026

Vitamin B3 shows promise for treating rare genetic disorder

Scientists at Gladstone Institutes have flipped the traditional approach to finding potential treatments for deadly diseases.

25 Feb 2026

RSV and COVID-19 trigger different immune responses in infants

Young infants hospitalized with respiratory syncytial virus (RSV) often become much sicker compared to those infected with SARS-CoV-2, the virus that causes COVID-19.

25 Feb 2026

Ketogenic diet alters brain signaling to reduce epileptic seizures

A ketogenic diet - one that is high in fat and extremely low in carbohydrates - has been known for decades to reduce seizures in some epilepsy patients.

25 Feb 2026

Muscles retain molecular memory of repeated inactivity

Muscle loss, or atrophy, due to inactivity is common after illness, injury, hospitalization or falls, and becomes increasingly frequent with aging.

25 Feb 2026

New Pico C technology maps genome structure before activation

For decades, scientists viewed the genome of a newly fertilised egg as a structural 'blank slate' – a disordered tangle of DNA waiting for the embryo to 'wake up' and start reading its own genetic instructions.

24 Feb 2026

Study sheds light on behavior of yeast cells in the gut

A new study sheds light on the behavior of yeast cells in the gut, paving the way for new lines of yeast that more efficiently produce therapeutic drugs tailored to address specific diseases.

24 Feb 2026

Mizzou tackles rising alpha-gal syndrome cases with research and outreach

The University of Missouri is on the front lines of helping patients with alpha-gal syndrome - a potentially life-threatening red-meat allergy caused by lone star tick bites.

24 Feb 2026