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Light-activated cancer drugs without toxic side effects are closer to becoming reality

Future cancer drugs that are activated by light and don't cause the toxic side-effects of current chemotherapy treatments are closer to becoming a reality, thanks to new research made possible by the Monash Warwick Alliance, an intercontinental collaboration between the University of Warwick and Monash University.

13 Feb 2018

Study reports longer survival for obese men with metastatic melanoma

Obese patients with metastatic melanoma who are treated with targeted or immune therapies live significantly longer than those with a normal body mass index, investigators report in a study published in Lancet Oncology of 1,918 patients in six independent clinical cohorts.

13 Feb 2018

Scientists synthesize new multifunctional compound that has anti-tumor properties

A research team of the UNN Faculty of Chemistry led by Professor Alexei Fedorov has developed and synthesized a new multifunctional compound that possesses anti-tumor properties that are due to several independent effects.

2 Feb 2018

Scientists identify new approach to enhance bone healing

When a patient breaks a bone, there's a possibility the fracture won't heal properly or quickly -- even with the aid of pins, plates or a cast.

1 Feb 2018

Newly solved glucagon receptor structure provides most accurate template for drug design

Class B G protein-coupled receptors (GPCRs) exert essential action in hormonal homeostasis and are important therapeutic targets for a variety of diseases including metabolic disorders such as type 2 diabetes.

4 Jan 2018

Study finds role of ligands in allergic sensitization phase

Researchers from Universidad Politécnica de Madrid find direct evidence that the ligands, compounds carried by allergens, are actively involved in the allergic sensitization phase.

26 Dec 2017

Silky webs of spiders may hold secrets to repairing our skeletons

Some secrets to repairing our skeletons might be found in the silky webs of spiders, according to recent experiments guided by supercomputers. Scientists involved say their results will help understand the details of osteoregeneration, or how bones repair themselves.

20 Dec 2017

Advances in BioAFM

AFM is quite a versatile technique and we see a great potential of this technology for life science applications. It is still fairly new in Bio community, however very well accepted not only as imaging tools but as a versatile instrument for nanomechanical measurements.

From Bruker Nano Surfaces and Metrology 19 Dec 2017

Study finds mechanism of resistance to checkpoint inhibitors and way to reverse it

Researchers have discovered a mechanism of resistance to checkpoint inhibitors and how to reverse it. The biomarker results from the IMvigor210 study are reported at the ESMO Immuno Oncology Congress 2017.

8 Dec 2017

New first line combination therapy shows promising results in patients with advanced NSCLC

A new combination therapy for the first line treatment of advanced non-squamous non-small-cell lung cancer (NSCLC) improves progression-free survival (PFS), according to results of phase III IMpower150 trial presented at the ESMO Immuno Oncology Congress 2017.

7 Dec 2017

Jawbone loss linked to onset of rheumatoid arthritis

Jawbone loss caused by periodontitis predates the onset of rheumatoid arthritis. This according to research from Umeå University in Sweden presented in the journal Arthritis & Rheumatology.

1 Dec 2017

UNIGE scientists unravel key role played by the liver in onset of type-2 diabetes

Affecting as many as 650 million people worldwide, obesity has become one of the most serious global health issues. Among its detrimental effects, it increases the risk of developing metabolic conditions, and primarily type-2 diabetes.

28 Nov 2017

TSRI chemists invent new method that simplifies late-stage modification of drug molecules

Chemists at The Scripps Research Institute have invented a technique that overcomes a long-standing problem in organic chemistry and should streamline the process of discovery and development for many new drugs.

27 Nov 2017

Study uncovers key mechanism by which tumors develop resistance to radiation therapy

A Ludwig Cancer Research study has uncovered a key mechanism by which tumors develop resistance to radiation therapy and shown how such resistance might be overcome with drugs that are currently under development.

23 Nov 2017

Liver disease in children with Alagille Syndrome caused by malformations of bile ducts

Serious liver and heart problems can affect children with Alagille Syndrome early in life. While there is as yet no cure, researchers at Karolinska Institutet in Sweden have discovered that the liver disease part of the syndrome is caused by specific malformations of the bile ducts.

21 Nov 2017

Probing living cells with AFM

An interview with Prof. David Alsteens, Université Catholique de Louvain conducted by April Cashin-Garbutt, MA (Cantab).

From Bruker Nano Surfaces and Metrology 21 Nov 2017

Monoclonal antibody effectively blocks development of graft-versus-host disease, research shows

Newly published research provides preclinical proof-of-concept for the ability of PRO 140, a humanized anti-CCR5 monoclonal antibody under development by CytoDyn Inc., to effectively block the development of graft-versus-host disease (GvHD), a potentially lethal complication of bone marrow stem cell (BMSC) transplantation.

14 Nov 2017