Whole Genome Sequencing News and Research

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Greater gut bacteria diversity linked to longer progression-free survival in metastatic melanoma patients

The blend of bacteria in the digestive tract of metastatic melanoma patients is associated with disease progression or delay in patients treated with immunotherapy, researchers at The University of Texas MD Anderson Cancer Center report at the 2017 annual meeting of the American Society of Clinical Oncology.

6 Jun 2017

ATCC and One Codex form partnership to address microbiome research needs

ATCC, a global leader in biological materials development, management and standards, and One Codex, a leading microbial genomics and metagenomics platform, today announced the formation of a partnership to address microbiome research needs.

2 Jun 2017

Gene editing technology can introduce hundreds of unintended mutations, study shows

As CRISPR-Cas9 starts to move into clinical trials, a new study published in Nature Methods has found that the gene-editing technology can introduce hundreds of unintended mutations into the genome.

29 May 2017

Whole-exome sequencing may routinely miss detecting some disease-causing genes, say researchers

Whole-exome DNA sequencing -- a technology that saves time and money by sequencing only protein-coding regions and not the entire genome -- may routinely miss detecting some genetic variations associated with disease, according to Penn State researchers who have developed new ways to identify such omissions.

24 Apr 2017

Collaboration between Hamilton Robotics and Illumina creates noninvasive streamlined prenatal testing solution

Hamilton Robotics continues to strengthen their ongoing partnership with Illumina, Inc. through the collaborative development of the VeriSeq™ NIPT Solution for high-throughput noninvasive prenatal testing (NIPT).

From Hamilton Process Analytics 14 Apr 2017

Genetic screening and counseling likely to benefit childhood cancer survivors, study suggests

Twelve percent of childhood cancer survivors carry germline mutations that put them or their children at increased risk of developing cancer, according to a landmark study presented today at the annual meeting of the American Association for Cancer Research.

4 Apr 2017

Rarely studied faulty USF3 gene may predispose individuals to thyroid cancer

Charis Eng, M.D., Ph.D., of Cleveland Clinic and her team have discovered that a faulty, rarely studied gene called USF3 may predispose individuals to thyroid cancer. They recently published this discovery in Human Molecular Genetics.

29 Mar 2017

Research shows how Ohr enzyme plays central role in bacterial anti-oxidant defense

A research project conducted at the University of São Paulo in Brazil in collaboration with other Brazilian research institutions and abroad has revealed new aspects of the action mechanism of organic hydroperoxide resistance (Ohr) enzyme, which enables several species of bacteria to neutralize oxidizing substances released by the defense system of the host organism, be it a plant or an animal.

21 Mar 2017

MLL, IBM and Illumina collaborate to build new cognitive technology prototype for improving leukemia treatment

Munich Leukemia Laboratory, a state-of-the-art leukemia and lymphoma diagnostic and research laboratory based in Munich, has teamed up with IBM and Illumina, Inc. to help build a new cognitive technology prototype that aims to help researchers improve leukemia treatment.

From Illumina, Inc. 9 Mar 2017

New report expresses ethical concerns about use of non-invasive prenatal testing

A new report on non-invasive prenatal testing by the UK's Nuffield Council on Bioethics expresses concerns about the way the test is being sold by private providers.

1 Mar 2017

UC San Diego researchers receive new grant to advance malaria research

An international research team, led by principal investigator Elizabeth A. Winzeler, PhD, professor in the pediatric division of host-microbe systems and therapeutics at University of California San Diego School of Medicine, and colleagues have received a three-year, $4.7 million supplemental grant from the Bill & Melinda Gates Foundation to advance their development of improved therapies for malaria eradication and elimination.

17 Feb 2017

Professor aims to develop shortcuts for targeted and effective cancer therapy

The aim is to identify precisely the one drug, or the correct combination of drugs, that are most effective against the specific tumor present in each patient. Professor hopes that new tools will come into use in the next five years.

13 Feb 2017

Scientists identify gene variants that predispose children to developing Kawasaki disease

Kawasaki disease (KD) is the most common acquired heart disease in children. Untreated, roughly one-quarter of children with KD develop coronary artery aneurysms -- balloon-like bulges of heart vessels -- that may ultimately result in heart attacks, congestive heart failure or sudden death.

9 Feb 2017

Sapientia genome analysis software by Congenica could cut costs and save lives

Whole genome analysis (WGA) enables rapid diagnosis of rare disease, ensuring that an appropriate course of management and treatment can be administered, possibly within days for acute neonatal cases, cutting the cost of intensive care and potentially saving lives. Rapid diagnosis is one of the many benefits of using the Sapientia™ genome analysis and interpretation platform that Dr Nick Lench, Chief Operating Officer of Congenica, will be discussing at Precision Medicine World Conference (PMWC) 2017 on January 23rd at 3.15pm.

23 Jan 2017

Epigenetic changes drive successful metastases of pancreatic cancer cells

A multicenter team of researchers reports that a full genomic analysis of tumor samples from a small number of people who died of pancreatic cancer suggests that chemical changes to DNA that do not affect the DNA sequence itself yet control how it operates confer survival advantages on subsets of pancreatic cancer cells.

17 Jan 2017

NovaSeq, the new sequencer by Illumina, said to transform the field of genomics

Illumina, Inc., the global leader in next-generation sequencing technology, today introduced the NovaSeqTM Series, a new and scalable sequencing architecture expected one day to enable a $100 genome. Unveiled at the J.P. Morgan Healthcare Conference, this platform redefines high throughput sequencing with unrivaled throughput, ease of use, low per sample costs, and unmatched flexibility.

From Illumina, Inc. 12 Jan 2017

EUCAST experts say that genetic testing methods cannot be used to determine antimicrobial susceptibility

Experts at the European Committee on Antimicrobial Susceptibility Testing, who define the optimal drug concentrations to inhibit the growth of pathogens, have found that genetic methods cannot yet be used to test for susceptibility in a number of important bacterial species.

9 Dec 2016

Wellcome Trust Sanger Institute open new biodata innovation centre and sequencing facility

The UK Prime Minister Rt Hon Theresa May today joined key stakeholders from across the life sciences sector to open the Wellcome Trust Sanger Institute’s new Bridget Ogilvie Building and the Biodata Innovation Centre at the Wellcome Genome Campus in Cambridge.

22 Nov 2016

ESCMID experts raise awareness for optimal use of antibiotics to combat AMR

Experts at the European Society of Clinical Microbiology and Infectious Disease (ESCMID) are joining colleagues across the globe this week to promote prudent use of antibiotics.

21 Nov 2016

Researchers propose zebrafish as model to predict effects of EDCs

Water is vital for our survival. However, water quality is always a concern for public health authorities as it may contain diverse environmental pollutants, including endocrine disrupting chemicals (EDCs).

18 Nov 2016