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Hyperion Therapeutics receives FDA approval for Ravicti to treat urea cycle disorders

The U.S. Food and Drug Administration today approved Ravicti (glycerol phenylbutyrate) for the chronic management of some urea cycle disorders (UCDs) in patients ages 2 years and older.

1 Feb 2013

Brandeis University researchers to receive Wiley Prize in Biomedical Sciences

Deborah E. Wiley, Chair of The Wiley Foundation, John Wiley & Sons, Inc., announced today that the twelfth annual Wiley Prize in Biomedical Sciences will be awarded to Dr. Michael Young, Rockefeller University, Dr. Jeffrey Hall, Brandeis University (Emeritus), and Dr. Michael Rosbash, Brandeis University.

1 Feb 2013

Merck full-year 2012 worldwide sales decrease 2% to $47.3 billion

Merck, known as MSD outside the United States and Canada, today announced financial results for the fourth quarter and full year of 2012.

1 Feb 2013

Three Robert Wood Johnson members win Edward J. Ill Excellence in Medicine Awards

Three members of the University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School faculty have been named 2013 recipients of the prestigious Edward J. Ill Excellence in Medicine Awards, highlighting their expertise as exceptional educators or researchers.

1 Feb 2013

Study supports hypothesis that disulfiram reduces drug consumption by blocking DβH

Disulfiram was the first medication approved for the treatment of alcoholism over 50 years ago. It works, at least in part, by preventing the metabolism of an alcohol by-product, acetaldehyde. High levels of acetaldehyde in the body quickly cause unpleasant symptoms, including nausea, vomiting, headache, and accelerated heart rate. Thus, disulfiram provides a very strong incentive to avoid drinking.

1 Feb 2013

Gene variant boosts ulcer susceptibility in NSAID users

A single nucleotide polymorphism in the cytochrome P450 2C gene cluster influences the risk for peptic ulcer disease in people taking non-steroidal anti-inflammatory drugs, a study reveals.

31 Jan 2013

Being married and cohabiting reduces risk of heart attack in both men and women in all age groups

A large population-based study from Finland has shown that being unmarried increases the risk of fatal and non-fatal heart attack in both men and women whatever their age. Conversely, say the study investigators, especially among middle-aged couples, being married and cohabiting are associated with "considerably better prognosis of acute cardiac events both before hospitalization and after reaching the hospital alive".

31 Jan 2013

Finding medical applications for unused inventions: an interview with Gabriel Mecklenburg, Co-Founder of Marblar

Marblar is gamifying the process of technology transfer. We post technology on our platform in the form of a challenge, and the Marblar community then competes to uncover new problems these technologies could solve – thereby discovering new market applications for these technologies.

31 Jan 2013

Scientists review damage-control in metabolism

In this week's issue of the prestigious journal Nature Chemical Biology, scientists Carole Linster (University of Luxembourg), Emile Van Schaftingen (Louvain University), and Andrew D. Hanson (University of Florida, Gainesville) review an important, but so far neglected, part of metabolism, namely metabolite damage-control.

31 Jan 2013

Researchers identify mechanism by which vancomycin resistance spreads between bacteria

Worldwide, many strains of the bacterium Staphyloccocus aureus, commonly known as staph infections, are already resistant to all antibiotics except vancomycin. But as bacteria are becoming resistant to this once powerful antidote, S. aureus has moved one step closer to becoming an unstoppable killer.

31 Jan 2013

Enzymes may have new role as intelligent micro and nanomotors

Enzymes, workhorse molecules of life that underpin almost every biological process, may have a new role as "intelligent" micro- and nanomotors with applications in medicine, engineering and other fields.

31 Jan 2013

Hydrogen sulfide may play a wide-ranging role in staving off aging

Hydrogen sulfide (H2S) may play a wide-ranging role in staving off aging, according to a paper published online ahead of print in the journal Molecular and Cellular Biology.

30 Jan 2013

DFG again approves funding for Mainz University to promote cardiovascular research

The German Research Foundation (DFG) has again approved funding for the Department of Internal Medicine II of the Mainz University Medical Center to promote cardiovascular research - for the second time within only a few weeks.

30 Jan 2013

FDA approves Genzyme’s KYNAMRO to treat homozygous familial hypercholesterolemia

Genzyme, a Sanofi company, and Isis Pharmaceuticals Inc., today announced that the U.S. Food and Drug Administration (FDA) has approved its New Drug Application (NDA) for KYNAMROTM (mipomersen sodium) injection.

30 Jan 2013

SOD1 enzyme protects cells by regulating cell energy and metabolism

Just like a comic book super hero, you could say that the enzyme superoxide dismutase (SOD1) has a secret identity. Since its discovery in 1969, scientists believed SOD1's only role was to protect living cells against damage from free radicals. Now, researchers at the Johns Hopkins Bloomberg School of Public Health have discovered that SOD1 protects cells by regulating cell energy and metabolism. The results of their research were published January 17, 2013, in the journal Cell.

30 Jan 2013

Phenformin decreases size of lung tumors and increases survival in mice

Ever since discovering a decade ago that a gene altered in lung cancer regulated an enzyme used in therapies against diabetes, Reuben Shaw has wondered if drugs originally designed to treat metabolic diseases could also work against cancer.

30 Jan 2013

Genzyme receives FDA approval for Kynamro to treat homozygous familial hypercholesterolemia

The U.S. Food and Drug Administration today approved Kynamro (mipomersen sodium) injection as an addition to lipid-lowering medications and diet to treat patients with a rare type of high cholesterol called homozygous familial hypercholesterolemia (HoFH).

30 Jan 2013

Dectin-1 potential target for nasal polyposis

The transmembrane protein Dectin-1 appears to play a role in the pathogenesis of nasal polyposis, providing a potential new target for treating the condition, report Chinese researchers.

29 Jan 2013

Scientists identify genetic process in which normal liver cells transform into cancerous ones

A team of scientists from the Cancer Science Institute of Singapore (CSI) at the National University of Singapore (NUS) has identified a genetic process in which normal liver cells transform into cancerous ones. The finding provides new understanding into the pathogenesis of human cancers.

29 Jan 2013

Blue light can selectively eradicate skin and soft tissue infections

Blue light can selectively eradicate Pseudomonas aeruginosa infections of the skin and soft tissues, while preserving the outermost layer of skin, according to a proof-of-principle study led by Michael R. Hamblin of the Massachusetts General Hospital, and the Harvard Medical School, Boston.

29 Jan 2013

Enzyme News and Research

Hyperion Therapeutics receives FDA approval for Ravicti to treat urea cycle disorders

Brandeis University researchers to receive Wiley Prize in Biomedical Sciences

Merck full-year 2012 worldwide sales decrease 2% to $47.3 billion

Three Robert Wood Johnson members win Edward J. Ill Excellence in Medicine Awards

Study supports hypothesis that disulfiram reduces drug consumption by blocking DβH

Gene variant boosts ulcer susceptibility in NSAID users

Being married and cohabiting reduces risk of heart attack in both men and women in all age groups

Finding medical applications for unused inventions: an interview with Gabriel Mecklenburg, Co-Founder of Marblar

Scientists review damage-control in metabolism

Researchers identify mechanism by which vancomycin resistance spreads between bacteria

Enzymes may have new role as intelligent micro and nanomotors

Hydrogen sulfide may play a wide-ranging role in staving off aging

DFG again approves funding for Mainz University to promote cardiovascular research

FDA approves Genzyme’s KYNAMRO to treat homozygous familial hypercholesterolemia

SOD1 enzyme protects cells by regulating cell energy and metabolism

Phenformin decreases size of lung tumors and increases survival in mice

Genzyme receives FDA approval for Kynamro to treat homozygous familial hypercholesterolemia

Dectin-1 potential target for nasal polyposis

Scientists identify genetic process in which normal liver cells transform into cancerous ones

Blue light can selectively eradicate skin and soft tissue infections

Biochemistry eBook

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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