Enzyme News and Research

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Research opens new potential target against enterics

In research published in Nature Chemical Biology, scientists from RIKEN in Japan have discovered a surprisingly simple mechanism through which enterics can adjust to the very different oxygen environments inside the human gut and outside.

12 Nov 2014

New findings could help develop therapeutic options for glycogen storage disease

Glycogen storage disorders, which affect the body's ability to process sugar and store energy, are rare metabolic conditions that frequently manifest in the first years of life. Often accompanied by liver and muscle disease, this inability to process and store glucose can have many different causes, and can be difficult to diagnose.

11 Nov 2014

First steps in the origin of pancreatic cancer identified by Mayo Clinic researchers

Researchers at Mayo Clinic's campus in Jacksonville say they have identified first steps in the origin of pancreatic cancer and that their findings suggest preventive strategies to explore.

11 Nov 2014

Researchers explain interaction between HNRNPA2B1 protein and pancreatic cancer development

Researchers from the University of Barcelona have described an interaction between the protein HNRNPA2B1 and pancreatic cancer development which remained unknown. The study, published in the journal Gastroenterology, has proved in human cancer cell lines that this protein is essential to the correct activity of the oncogenic protein KRAS, related to cancer start and development.

11 Nov 2014

Obeticholic acid improves liver health in people with nonalcoholic steatohepatitis

An experimental drug aimed at treating a common liver disease showed promising results and potential problems in a multicenter clinical trial funded by the National Institutes of Health. The FLINT study found that people with nonalcoholic steatohepatitis (NASH) who took obeticholic acid (OCA) had improved liver health during that period, including decreased inflammation and fat in the liver and decreased body weight versus people receiving a placebo. OCA was also associated with increases in itching and total cholesterol.

7 Nov 2014

Scientists develop human stem cell disease model of Parkinson's disease in a dish

A team of scientists led by The New York Stem Cell Foundation Research Institute successfully created a human stem cell disease model of Parkinson's disease in a dish. Studying a pair of identical (monozygotic) twins, one affected and one unaffected with Parkinson's disease, another unrelated Parkinson's patient, and four healthy control subjects, the scientists were able to observe key features of the disease in the laboratory, specifically differences in the patients' neurons' ability to produce dopamine, the molecule that is deficient in Parkinson's disease.

6 Nov 2014

Joslin researcher identifies molecular pathway that causes neural tube defects in diabetic pregnancies

Mary R. Loeken, Ph.D., Investigator in the Section on Islet Cell and Regenerative Biology at Joslin Diabetes Center and Associate Professor of Medicine at Harvard Medical School, has discovered a molecular pathway responsible for neural tube defects in diabetic pregnancies. Her latest research findings in this pathway were published in the October issue of Diabetes.

6 Nov 2014

EKF Molecular Diagnostics to present at AMP annual meeting

EKF, announces that senior executives from EKF Molecular Diagnostics including CEO, Andrew Webb, will be present at the Association for Molecular Pathology.

From EKF Diagnostics 6 Nov 2014

Janssen working with The Union to evaluate SIRTURO (bedaquiline) in patients with MDR-TB

Janssen Research & Development, LLC today announced a collaboration with the International Union Against Tuberculosis and Lung Disease (The Union) to include SIRTURO (bedaquiline) in the STREAM Study.

6 Nov 2014

Abide, Oxford partner to explore therapeutic potential of serine hydrolases

Abide Therapeutics announced today that the Company has entered into a collaborative agreement with the University of Oxford and the Oxford University Hospitals NHS Trust to explore the therapeutic potential of serine hydrolases, one of the largest enzyme classes with validated but under explored class of drug targets.

5 Nov 2014

Researchers identify potential therapeutic target for glioblastoma

A multicenter team of researchers has identified an enzyme key to the survival and spread of glioblastoma cancer cells that is not present in healthy brain cells, making the enzyme a promising therapeutic target.

4 Nov 2014

Lab-grown tissues may provide new treatments for injuries, damage to the joints

Lab-grown tissues could one day provide new treatments for injuries and damage to the joints, including articular cartilage, tendons and ligaments.

31 Oct 2014

KU researchers find potential therapeutic target for triple-negative breast cancer

A team at the University of Kansas School of Medicine has identified a potential target for treating breast cancer, including a particularly deadly form of the disease.

30 Oct 2014

Landmark study provides new insight into function of enzyme related to BRCA1 protein

A landmark study to be published in the October 30, 2014 print edition of the journal Nature provides new insight into the function of an enzyme related to the BRCA1 breast-cancer protein. The study by a team at Penn State University is the first to produce a detailed working image of an enzyme in the Polycomb Repressive Complex 1 (PRC1) -- a group that regulates cell development and is associated with many types of cancer.

30 Oct 2014

UCLA research could lead to simple saliva test for early diagnosis of deadly diseases

UCLA research could lead to a simple saliva test capable of diagnosing — at an early stage — diabetes and cancer, and perhaps neurological disorders and autoimmune diseases.

30 Oct 2014

Genetic differences contribute to risk for autism

Small differences in as many as a thousand genes contribute to risk for autism, according to a study led by Mount Sinai researchers and the Autism Sequencing Consortium, and published today in the journal Nature.

29 Oct 2014

Researchers find potential target for therapies to treat cocaine addiction

A study led by investigators from Massachusetts General Hospital and the Perelman School of Medicine at the University of Pennsylvania has identified a potential target for therapies to treat cocaine addiction.

29 Oct 2014

Study: New blood substitute may be safer than donor blood

A new blood substitute has been developed which could be a safer and more effective alternative to using donor blood.

29 Oct 2014

Influential colleagues convince doctors to try new therapies

Doctors are more likely to try a new therapy when they are persuaded to do so by an influential colleague, reports a new Northwestern University study whose findings on adopting innovations also have relevance for business, education and research.

28 Oct 2014

CHOP, Temple University to jointly investigate new methods for eradicating HIV

The Children's Hospital of Philadelphia and Temple University have received a joint $4.3 million, four-year grant from the National Institute of Mental Health to investigate new methods to eradicate HIV that lurks in brain cells despite conventional antiviral treatments.

28 Oct 2014

Enzyme News and Research

Research opens new potential target against enterics

New findings could help develop therapeutic options for glycogen storage disease

First steps in the origin of pancreatic cancer identified by Mayo Clinic researchers

Researchers explain interaction between HNRNPA2B1 protein and pancreatic cancer development

Obeticholic acid improves liver health in people with nonalcoholic steatohepatitis

Scientists develop human stem cell disease model of Parkinson's disease in a dish

Joslin researcher identifies molecular pathway that causes neural tube defects in diabetic pregnancies

EKF Molecular Diagnostics to present at AMP annual meeting

Janssen working with The Union to evaluate SIRTURO (bedaquiline) in patients with MDR-TB

Abide, Oxford partner to explore therapeutic potential of serine hydrolases

Researchers identify potential therapeutic target for glioblastoma

Lab-grown tissues may provide new treatments for injuries, damage to the joints

KU researchers find potential therapeutic target for triple-negative breast cancer

Landmark study provides new insight into function of enzyme related to BRCA1 protein

UCLA research could lead to simple saliva test for early diagnosis of deadly diseases

Genetic differences contribute to risk for autism

Researchers find potential target for therapies to treat cocaine addiction

Study: New blood substitute may be safer than donor blood

Influential colleagues convince doctors to try new therapies

CHOP, Temple University to jointly investigate new methods for eradicating HIV

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