Immune Response News and Research

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Composition of microbes in the gut changes dramatically during pregnancy

The composition of microbes in the gut changes dramatically during pregnancy, according to a study published by Cell Press in the August 3rd issue of the journal Cell. Although these changes are associated with metabolic disease under most circumstances, they could be beneficial in pregnant women.

3 Aug 2012

Researchers develop bioactive coating that actively suppresses brain's immune response

Brain-computer interfaces are at the cutting edge for treatment of neurological and psychological disorder, including Parkinson's, epilepsy, and depression. Among the most promising advance is deep brain stimulation (DBS) - a method in which a silicon chip implanted under the skin ejects high frequency currents that are transferred to the brain through implanted electrodes that transmit and receive the signals.

1 Aug 2012

Poor sleep can reduce effectiveness of vaccines

As moms have always known, a good night's sleep is crucial to good health -- and now a new study led by a UCSF researcher shows that poor sleep can reduce the effectiveness of vaccines.

1 Aug 2012

Two new targets could enhance the body's defenses against West Nile and hepatitis C

Two new targets have been discovered for antiviral therapies and vaccines strategies that could enhance the body's defenses against such infectious diseases as West Nile and hepatitis C. The targets are within the infection warning system inside living cells.

31 Jul 2012

Promising implications for improving cellular immunotherapy for treatment of cancer

New research from the Trudeau Institute laboratory of Dr. Edward L. Pearce (Washington University) has promising implications for improving a treatment for cancer known as cellular immunotherapy. The findings were just published in the The Journal of Immunology.

30 Jul 2012

Researchers describe new human tissue dendritic cell with cross-presenting function

Researchers in Newcastle and Singapore have identified a new type of white blood cell which activates a killing immune response to an external source - providing a new potential target for vaccines for conditions such as cancer or Hepatitis B.

30 Jul 2012

Scientists decipher molecular causes of life-threatening candida fungal infections

With infectious diseases, it is often not the pathogen itself, but rather an excessive inflammatory immune responses death, for instance as a result of organ damage. On intensive care units, sepsis is the second-most common cause of death worldwide. In patients with a severely compromised immune system specially, life-threatening candida fungal infections represent a high risk of sepsis.

30 Jul 2012

Paper highlights clinical and immunological activity of immatics’ IMA901 in renal cell carcinoma

immatics biotechnologies GmbH, a clinical-stage biopharmaceutical company developing advanced therapeutic vaccines that are active against cancer, today announced that key data covering the scientific and clinical development of its lead cancer vaccine, IMA901, have been published in Nature Medicine.

30 Jul 2012

Vaccine complex delivered safely by piggybacking onto 3D DNA nanostructures

In a quest to make safer and more effective vaccines, scientists at the Biodesign Institute- at Arizona State University have turned to a promising field called DNA nanotechnology to make an entirely new class of synthetic vaccines.

27 Jul 2012

Skin microbiota may help protect the body from infection

A research team at the National Institutes of Health has found that bacteria that normally live in the skin may help protect the body from infection. As the largest organ of the body, the skin represents a major site of interaction with microbes in the environment.

27 Jul 2012

NIDA announces 2012 recipient of Avant-Garde Award for Medications Development

Dr. Gary R. Matyas has been selected the 2012 recipient of the NIDA Avant-Garde Award for Medications Development. Matyas proposes to develop an effective, safe and easily manufactured combination anti-heroin/HIV vaccine that could treat heroin addiction while at the same time prevent HIV infection in those receiving the vaccine.

26 Jul 2012

NBTI participates in ICT-107 phase II trial for glioblastoma multiforme

Researchers at Northwestern Brain Tumor Institute (NBTI) are seeking to understand if a vaccine made from a patient's own blood cells may slow the growth of a type of brain tumor.

25 Jul 2012

Giving patients a new immune system can cure Crohn's disease

Researchers at Fred Hutchinson Cancer Research Center have opened a clinical trial to test the theory that giving a patient a new immune system can cure severe cases of Crohn's disease, a chronic inflammatory condition of the gastrointestinal tract.

25 Jul 2012

Favorable results from BioCryst’s ulodesine plus allopurinol Phase 2b trial on gout

BioCryst Pharmaceuticals, Inc. announced favorable 52-week safety results and sustained efficacy from the extension phase of its randomized Phase 2b trial of ulodesine (BCX4208) added to allopurinol in patients with gout who had failed to reach the serum uric acid (sUA) therapeutic goal of <6 mg/dL on allopurinol alone, as well as positive Phase 2 safety results in patients with mild to moderate renal impairment.

25 Jul 2012

Study represents new use of bone marrow transplantation

24 Jul 2012

Scientists identify mechanisms by which GLP-1 protects against kidney disease, diabetes

Scientists at Joslin Diabetes Center have identified biological mechanisms by which glucagon-like peptide-1 (GLP-1), a gut hormone, protects against kidney disease, and also mechanisms that inhibit its actions in diabetes.

24 Jul 2012

PAMAM G-3 actually prevents activation of the process that leads to thrombosis

A compound that mops up debris of damaged cells from the bloodstream may be the first in a new class of drugs designed to address one of medicine's most difficult challenges -- stopping the formation of blood clots without triggering equally threatening bleeding.

24 Jul 2012

BioDiem presents positive findings of their eye disease drug at international conference

Australian infectious disease therapy and vaccine development company BioDiem Ltd (ASX: BDM) today announced positive results from formal studies of its BDM-E eye disease drug, presented over 21 – 22 July at the International Society for Eye Research (ISER) meeting in Berlin, Germany. The ISER convenes leading researchers and clinicians in the area of eye disease.

22 Jul 2012

Experts examine host recognition of Staphylococcus and E.coli bacteria

We are surrounded by bacteria, viruses, fungi and parasites. The fact that we nevertheless do not fall prey to infections is thanks to certain cellular sensor molecules such as toll-like receptors (TLR), which recognize the molecular structure of pathogens and intercede by ensuring an often completely unnoticeable elimination of the invaders. Their immune-activating abilities were only detected in 1998, a discovery which was awarded with the Nobel Prize

21 Jul 2012

Mother's exposure to air pollution increases risk of obesity and insulin resistance in offspring

Pregnant mice exposed to high levels of air pollution gave birth to offspring with a significantly higher rate of obesity and insulin resistance in adulthood than those that were not exposed to air pollution. This effect seemed especially prevalent in male mice, which were heavier regardless of diet. These findings, published online in the FASEB Journal, suggests a link between diesel exhaust exposure in utero and bulging waistlines in adulthood.

20 Jul 2012

Immune Response News and Research

Composition of microbes in the gut changes dramatically during pregnancy

Researchers develop bioactive coating that actively suppresses brain's immune response

Poor sleep can reduce effectiveness of vaccines

Two new targets could enhance the body's defenses against West Nile and hepatitis C

Promising implications for improving cellular immunotherapy for treatment of cancer

Researchers describe new human tissue dendritic cell with cross-presenting function

Scientists decipher molecular causes of life-threatening candida fungal infections

Paper highlights clinical and immunological activity of immatics’ IMA901 in renal cell carcinoma

Vaccine complex delivered safely by piggybacking onto 3D DNA nanostructures

Skin microbiota may help protect the body from infection

NIDA announces 2012 recipient of Avant-Garde Award for Medications Development

NBTI participates in ICT-107 phase II trial for glioblastoma multiforme

Giving patients a new immune system can cure Crohn's disease

Favorable results from BioCryst’s ulodesine plus allopurinol Phase 2b trial on gout

Study represents new use of bone marrow transplantation

Scientists identify mechanisms by which GLP-1 protects against kidney disease, diabetes

PAMAM G-3 actually prevents activation of the process that leads to thrombosis

BioDiem presents positive findings of their eye disease drug at international conference

Experts examine host recognition of Staphylococcus and E.coli bacteria

Mother's exposure to air pollution increases risk of obesity and insulin resistance in offspring

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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