Mutation News and Research

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Caltech biologists identify mechanism by which beneficial bacteria reside, thrive in gastrointestinal tract

The human body is full of tiny microorganisms-hundreds to thousands of species of bacteria collectively called the microbiome, which are believed to contribute to a healthy existence. The gastrointestinal (GI) tract-and the colon in particular-is home to the largest concentration and highest diversity of bacterial species.

20 Aug 2013

New antibodies estimate risk of polyps developing into bowel cancer

Polyps in the mucosa of the colon are a common finding during screening colonoscopies. Some sub-groups of polyps are classed as precursors of bowel cancer. Until now, it has not been possible to precisely estimate the risk of these polyps developing into bowel cancer.

19 Aug 2013

Study: Gene that controls ageing process linked to cancer

A gene that helps control the ageing process by acting as a cell's internal clock has been linked to cancer by a major new study.

19 Aug 2013

Secondary cancers in melanoma patients treated for BRAF gene mutation require new strategies

Moffitt Cancer Center researchers suggest secondary cancers seen in melanoma patients who are being treated for a BRAF gene mutation may require new strategies, such as enhanced surveillance and combining BRAF-inhibitor therapy with other inhibitors, especially as they become more widely used.

17 Aug 2013

UCSF study shows potential for new treatment strategy for Parkinson’s disease

UC San Francisco scientists working in the lab used a chemical found in an anti-wrinkle cream to prevent the death of nerve cells damaged by mutations that cause an inherited form of Parkinson-s disease.

17 Aug 2013

Michigan researchers use TACC supercomputers to understand DNA bending, repair mechanisms

The biological information that makes us unique is encoded in our DNA. DNA damage is a natural biological occurrence that happens every time cells divide and multiply. External factors such as overexposure to sunlight can also damage DNA.

17 Aug 2013

Prion proteins responsible for Mad cow disease, Creutzfeld-Jakob disease

Mad cow disease and its cousin Creutzfeld-Jakob disease cause fatal spongy changes in brain tissue. Today, we know that these diseases are caused by prions, proteins that are folded incorrectly. A team of German researchers have now been able to follow how the diseased proteins aggregate and "infect" healthy ones on the atomic scale. Their report appears in the journal Angewandte Chemie.

16 Aug 2013

Scientists shed new light on molecular causes of age related degenerative disease

An international collaboration jointly led by scientists from Trinity College Dublin has shed new light on the origins and molecular causes of age related degenerative conditions including Motor Neurone Disease (MND). The new perspective provided by this work may lead the way to new treatments and early diagnoses.

16 Aug 2013

Kinetin stops the effects of Parkinson's disease on brain cells, say scientists

The active ingredient in an over-the-counter skin cream might do more than prevent wrinkles. Scientists have discovered that the drug, called kinetin, also slows or stops the effects of Parkinson's disease on brain cells.

16 Aug 2013

Mutational signatures in DNA explain genetic development, history of cancers in patients

Researchers have provided the first comprehensive compendium of mutational processes that drive tumour development. Together, these mutational processes explain most mutations found in 30 of the most common cancer types. This new understanding of cancer development could help to treat and prevent a wide-range of cancers.

16 Aug 2013

Researchers find possible mechanism of how cellular memory works

The DNA in human cells is translated into a multitude of proteins required for a cell to function. When, where and how proteins are expressed is determined by regulatory DNA sequences and a group of proteins, known as transcription factors, that bind to these DNA sequences.

16 Aug 2013

Researchers find recurrent genetic mutation linked to deadly thoracic aortic dissections

A multi-institutional team led by Dianna Milewicz, M.D., Ph.D., of The University of Texas Health Science Center at Houston (UTHealth) has found a recurrent genetic mutation that has been linked to deadly thoracic aortic dissections in family members as young as 17 years of age.

16 Aug 2013

Scientists have made breakthrough in understanding cancer-promoting action of herbal products

A team of scientists from the National Cancer Centre Singapore, Duke-NUS Graduate Medical School Singapore, and Taiwan's Chang Gung Memorial Hospital, LinKou, have made a breakthrough in understanding the cancer-promoting action of Aristolochic Acid (AA), a natural product of Aristolochia plants traditionally used in some Asian herbal remedies for weight loss and slimming.

14 Aug 2013

A*STAR's SIgN discovers new strategy to develop universal dengue vaccine

A new strategy that cripples the ability of the dengue virus to escape the host immune system has been discovered by A*STAR's Singapore Immunology Network. This breakthrough strategy opens a door of hope to what may become the world's first universal dengue vaccine candidate that can give full protection from all four serotypes of the dreadful virus.

14 Aug 2013

SIgN discovers strategy that cripples ability of dengue virus to escape host immune system

A new strategy that cripples the ability of the dengue virus to escape the host immune system has been discovered by A*STAR's Singapore Immunology Network (SIgN). This breakthrough strategy opens a door of hope to what may become the world's first universal dengue vaccine candidate that can give full protection from all four serotypes of the dreadful virus.

14 Aug 2013

Researchers discover why early pregnancy reduces breast cancer

An international scientific collaborative led by the Harvard Stem Cell Institute's Kornelia Polyak, MD, PhD, has discovered why women who give birth in their early twenties are less likely to eventually develop breast cancer than women who don't, triggering a search for a way to confer this protective state on all women.

13 Aug 2013

Researchers identify clear genetic risk factors in patients with severe epilepsy

Neurologists and epilepsy researchers from NYU Langone Medical Center were among scientists who have 329 random genetic mutations associated with two of the most severe forms of epilepsy, according to a paper published today in Nature.

13 Aug 2013

Rice researchers frame rules to design viral capsid proteins for gene therapy

Rice University researchers are making strides toward a set of rules to custom-design Lego-like viral capsid proteins for gene therapy.

13 Aug 2013

Study reveals new genetic mutations that cause epilepsy

Results from a landmark international study using state of the art technology has revealed new genetic mutations that cause epilepsy. The findings could help to advance treatments for the most severe forms of epilepsy.

13 Aug 2013

Nine risk factors for YOD in late adolescence

A study of Swedish men suggests nine risk factors, most of which can be traced to adolescence, account for most cases of young-onset dementia (YOD) diagnosed before the age of 65 years, according to a report published by JAMA Internal Medicine, a JAMA Network publication.

13 Aug 2013

Mutation News and Research

Caltech biologists identify mechanism by which beneficial bacteria reside, thrive in gastrointestinal tract

New antibodies estimate risk of polyps developing into bowel cancer

Study: Gene that controls ageing process linked to cancer

Secondary cancers in melanoma patients treated for BRAF gene mutation require new strategies

UCSF study shows potential for new treatment strategy for Parkinson’s disease

Michigan researchers use TACC supercomputers to understand DNA bending, repair mechanisms

Prion proteins responsible for Mad cow disease, Creutzfeld-Jakob disease

Scientists shed new light on molecular causes of age related degenerative disease

Kinetin stops the effects of Parkinson's disease on brain cells, say scientists

Mutational signatures in DNA explain genetic development, history of cancers in patients

Researchers find possible mechanism of how cellular memory works

Researchers find recurrent genetic mutation linked to deadly thoracic aortic dissections

Scientists have made breakthrough in understanding cancer-promoting action of herbal products

A*STAR's SIgN discovers new strategy to develop universal dengue vaccine

SIgN discovers strategy that cripples ability of dengue virus to escape host immune system

Researchers discover why early pregnancy reduces breast cancer

Researchers identify clear genetic risk factors in patients with severe epilepsy

Rice researchers frame rules to design viral capsid proteins for gene therapy

Study reveals new genetic mutations that cause epilepsy

Nine risk factors for YOD in late adolescence

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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