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MIT researchers use disarmed version of anthrax toxin to deliver cancer drugs

Bacillus anthracis bacteria have very efficient machinery for injecting toxic proteins into cells, leading to the potentially deadly infection known as anthrax. A team of MIT researchers has now hijacked that delivery system for a different purpose: administering cancer drugs.

26 Sep 2014

Imperial scientists map proteins affected by NMT enzyme, suggest potential way to treat cancer

Imperial chemists have gained fresh insights into how a disease-causing enzyme makes changes to proteins and how it can be stopped.

26 Sep 2014

TSRI scientists awarded DARPA grant to build artificial immune system

Scientists from both campuses of The Scripps Research Institute have been awarded a total of $7.9 million from the Defense Advanced Research Projects Agency of the U.S. Department of Defense.

25 Sep 2014

XAGE1 antibody confers survival benefits to lung adenocarcinoma patients

Patients with advanced lung adenocarcinoma who produce the XAGE1 antibody appear to survive twice as long as those who do not produce it, Japanese study data show.

24 Sep 2014

Newborn screening can prevent lifelong disability

When your baby was born you likely heard a loud cry and examined your baby to make sure he/she had a full set of adorable fingers and toes. But just imagine a few days after you arrive home, your phone rings: your baby has screened positive for a genetic disorder.

24 Sep 2014

Epidurals and reduced postpartum depression: an interview with Dr. Zakowski

The “maternity blues”, which resolve within 10 days of giving birth, occurs in up to 80% of new moms. A major depressive episode, by Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria, is defined as having at least a 2-week period of persistent depressed mood ...

23 Sep 2014

Scientists identify gene mutation that causes aplastic anemia

An international team of scientists has identified a gene mutation that causes aplastic anemia, a serious blood disorder in which the bone marrow fails to produce normal amounts of blood cells.

23 Sep 2014

MIT engineers find new strategy to combat superbugs

In recent years, new strains of bacteria have emerged that resist even the most powerful antibiotics. Each year, these superbugs, including drug-resistant forms of tuberculosis and staphylococcus, infect more than 2 million people nationwide, and kill at least 23,000. Despite the urgent need for new treatments, scientists have discovered very few new classes of antibiotics in the past decade.

22 Sep 2014

Biosensor opens up possibility of rapid, point-of-care diagnostic tool for cancer patients

An ultrasensitive biosensor made from the wonder material graphene has been used to detect molecules that indicate an increased risk of developing cancer.

22 Sep 2014

New study sheds light on longstanding question about role of mitochondria in motor neuron diseases

A new study by researchers at the University of Utah School of Medicine sheds light on a longstanding question about the role of mitochondria in debilitating and fatal motor neuron diseases and resulted in a new mouse model to study such illnesses.

22 Sep 2014

New finding could accelerate research to regenerate damaged tissue

Scientists at NYU Langone Medical Center have found a way to boost dramatically the efficiency of the process for turning adult cells into so-called pluripotent stem cells by combining three well-known compounds, including vitamin C.

19 Sep 2014

Activation of MMP-9 enzyme leads to behavioral problems connected to chronic stress

Why is it that when people are too stressed they are often grouchy, grumpy, nasty, distracted or forgetful? Researchers from the Brain Mind Institute at EPFL have just highlighted a fundamental synaptic mechanism that explains the relationship between chronic stress and the loss of social skills and cognitive impairment. When triggered by stress, an enzyme attacks a synaptic regulatory molecule in the brain. This was revealed by a work published in Nature Communications.

19 Sep 2014

TSRI scientists devise new vancomycin-based antibiotic to rout resistant bacteria

Scientists at The Scripps Research Institute have devised a new antibiotic based on vancomycin that is powerfully effective against vancomycin-resistant strains of MRSA and other disease-causing bacteria.

18 Sep 2014

Lilly, AstraZeneca partner to co-develop and commercialize potential Alzheimer's disease treatment

Eli Lilly and Company and AstraZeneca today announced an agreement to co-develop and commercialize AZD3293, an oral beta secretase cleaving enzyme (BACE) inhibitor currently in development as a potential treatment for Alzheimer's disease.

16 Sep 2014

Specific blood test could indicate neoadjuvant treatment regimens for ESCC patients

A blood test may be beneficial in indicating neoadjuvant treatment regimens for patients with esophageal squamous cell carcinoma (ESCC), according to research presented today at the American Society for Radiation Oncology's 56th Annual Meeting.

16 Sep 2014

Blocking bacteria's access to iron: an interview with Dr. Laxminarayana Devireddy

Iron is a key nutrient for nearly all living organisms, including bacteria. Iron is a cofactor for many enzymes necessary for basic metabolic reactions such as DNA synthesis and electron transport. Iron serves as the conduit for the electron transport chain that generates the energy necessary to drive the bacterial cell.

16 Sep 2014

Collaborative study takes important step toward finding targeted treatments for bladder cancer

The story of cancer care seems so simple: find the mutated gene that causes cancer and turn it off or fix it. But rarely does a single gene cause cancer. More often, many genes are altered together to drive the disease. So the challenge becomes sorting out which altered genes are the most to blame in which cancers.

16 Sep 2014

Researchers find new method to measure modified protein structures in biological sample

Cells regulate protein functions in a wide variety of ways, including by modifying the protein structure. In an instant, a protein can take on another form and perform no or even the "wrong" function: in humans, proteins that fold wrongly can cause serious diseases such as Alzheimer's, Parkinson's or cystic fibrosis.

16 Sep 2014

Amgen announces phase 3 ivabradine data for treatment of chronic HF

Amgen (NASDAQ: AMGN) today announced data from the Phase 3 SHIFT (Systolic Heart failure treatment with the If inhibitor ivabradine Trial) study evaluating ivabradine in patients with chronic heart failure (HF) were presented at the 18th Annual Scientific Meeting of the Heart Failure Society of America (HFSA) in Las Vegas.

15 Sep 2014

ChromaDex signs NIAGEN supply agreement with Healthy Directions

ChromaDex Corp., an innovative natural products company that provides proprietary ingredients and science-based solutions to the dietary supplement, food and beverage, cosmetic and pharmaceutical industries, announced today that it has entered into an ingredient supply agreement with Healthy Directions, a direct-to-consumer nutritional supplement retailer and wholly-owned subsidiary of Helen of Troy Limited.

11 Sep 2014

Enzyme News and Research

MIT researchers use disarmed version of anthrax toxin to deliver cancer drugs

Imperial scientists map proteins affected by NMT enzyme, suggest potential way to treat cancer

TSRI scientists awarded DARPA grant to build artificial immune system

XAGE1 antibody confers survival benefits to lung adenocarcinoma patients

Newborn screening can prevent lifelong disability

Epidurals and reduced postpartum depression: an interview with Dr. Zakowski

Scientists identify gene mutation that causes aplastic anemia

MIT engineers find new strategy to combat superbugs

Biosensor opens up possibility of rapid, point-of-care diagnostic tool for cancer patients

New study sheds light on longstanding question about role of mitochondria in motor neuron diseases

New finding could accelerate research to regenerate damaged tissue

Activation of MMP-9 enzyme leads to behavioral problems connected to chronic stress

TSRI scientists devise new vancomycin-based antibiotic to rout resistant bacteria

Lilly, AstraZeneca partner to co-develop and commercialize potential Alzheimer's disease treatment

Specific blood test could indicate neoadjuvant treatment regimens for ESCC patients

Blocking bacteria's access to iron: an interview with Dr. Laxminarayana Devireddy

Collaborative study takes important step toward finding targeted treatments for bladder cancer

Researchers find new method to measure modified protein structures in biological sample

Amgen announces phase 3 ivabradine data for treatment of chronic HF

ChromaDex signs NIAGEN supply agreement with Healthy Directions

Biochemical Assays for Efficient Hit Prioritization After Screening eBook

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Industry Focus eBook - Cell biology (5th edition)

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