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Novel treatment strategy during transplantation surgery could spare patients from rejection

Organ-transplant recipients often reject donated organs, but a new, two-pronged strategy developed by UC San Francisco researchers to specifically weaken immune responses that target transplanted tissue has shown promise in controlled experiments on mice.

11 Mar 2014

Promethera Biosciences, EMD Millipore partner to develop ready-to-use microfluidic perfusion liver assay

Promethera Biosciences, a company that develops innovative therapies for the treatment of liver diseases, today announces a collaboration with EMD Millipore to develop an improved ready-to-use microfluidic perfusion liver assay. This new product is designed to perform more robust studies in pre-clinical toxicity and drug metabolism.

11 Mar 2014

Skin cancer may increase risk of other cancers later in life

Australian author on the paper, Professor Rodney Sinclair, Professor of Medicine at the University of Melbourne and Director of Dermatology at Epworth HealthCare said that the risk decreased significantly with increasing age, but it remains higher compared with individuals who have never had NMSC.

10 Mar 2014

Exposure to UV light may exacerbate melanoma cells to creep outside blood vessels

Based on the pioneering work of Dr. Claire Lugassy and Dr. Raymond Barnhill at UCLA's Jonsson Comprehensive Cancer Center, a new study provides additional support for a process by which melanoma cells, a deadly form of skin cancer, can spread throughout the body by creeping like tiny spiders along the outside of blood vessels without ever entering the blood stream, and that this process is exacerbated by exposure to ultraviolet (UV) light.

10 Mar 2014

Tissue analysis near tumors holds promise for earlier detection, new treatments

Seemingly healthy cells may in fact hide clues that lung cancer will later develop, according to a study led by researchers at The University of Texas MD Anderson Cancer Center The research is published online in the Journal of the National Cancer Institute.

9 Mar 2014

Boehringer Ingelheim reports results from SVR12 Phase 3 trial in patients with HCV/HIV co-infection

Today Boehringer Ingelheim announced results from STARTVerso4 in patients with HCV/HIV co-infection. Hepatitis C viral cure 12 weeks after the conclusion of treatment (SVR12) was achieved by 72% of all patients in the trial. Patients were enrolled in either 120mg or 240mg faldaprevir dose groups.

6 Mar 2014

Low-dose oral interferon may reduce risk of HCV relapse in patients with mild liver fibrosis

Chronic hepatitis C virus (HCV) infection can lead to serious diseases such as cirrhosis and cancer of the liver, so viral clearance and prevention of relapse are important treatment goals.

6 Mar 2014

New study uses Lumosity games to detect subtle cognitive impairments in patients with cirrhosis

A new study from the University of Washington has found that performance on Lumosity games can distinguish between patients with cirrhosis of the liver, pre-cirrhotic patients, and healthy controls. The study used Lumosity games as psychometric tests to detect subtle cognitive impairments in patients with cirrhosis. The study is published in the March issue of the American Journal of Gastroenterology.

6 Mar 2014

Queensland scientists endeavor to stop spread of metastatic disease

Queensland scientists are working to stop the spread of one of the deadliest forms of skin cancer thanks to a $200,000 research grant awarded by Cancer Council Queensland.

5 Mar 2014

Study: 55% of women are passive smokers due to exposure to tobacco smoke

As shown in a study carried out by researchers at 13 research centres in Asturias, Gipuzkoa, Sabadell and Valencia, over half of non-smoking pregnant women, 55%, are passive smokers.

5 Mar 2014

Human Longevity, UC San Diego sign new collaborative research agreement

The new collaborative research agreement between Human Longevity Inc. and the University of California, San Diego, announced today, represents a significant and necessary step in efforts to research and translate the potential of the human genome into novel and real treatments and therapies able to change and improve the human condition.

5 Mar 2014

Metabolic profiling of liver cells suggests new treatments for cirrhosis patients

In a new study that could help doctors extend the lives of patients awaiting liver transplants, a Rice University-led team of researchers examined the metabolic breakdown that takes place in liver cells during late-stage cirrhosis and found clues that suggest new treatments to delay liver failure.

5 Mar 2014

Protamine antidote can be effective in reversing low-molecular-weight heparin

Low-molecular-weight heparin is commonly used in surgeries to prevent dangerous blood clots. But when patients experience the other extreme - uncontrolled bleeding - in response to low-molecular-weight heparin, there is no antidote.

4 Mar 2014

Research provides insight into biologic mechanisms that individual cancer cells use to metastasize to brain

New research from Memorial Sloan Kettering provides fresh insight into the biologic mechanisms that individual cancer cells use to metastasize to the brain.

4 Mar 2014

Costly new hepatitis C drug raises questions about who will pay

The new hepatitis C medication presents a dilemma for Medicaid and other insurers, who must balance the cost against the large numbers of people who might benefit. A single course of treatment costs $84,000.

4 Mar 2014

First Edition: March 3, 2014

Today's headlins include stories detailing ongoing challenges with state-run exchanges as well as previews of what's next regarding the federal budget process.

3 Mar 2014

Sunburn causes melanoma through direct and indirect processes

Melanoma is particularly dangerous because it can form metastases in vital organs such as the lungs, liver or brain. UV radiation is considered to be the most significant triggering factor.

3 Mar 2014

Researchers find unusual mutation strongly linked to rare liver cancer that affects teens

In the race for better treatments and possible cures, rare diseases are often left behind. In a collaboration of researchers at The Rockefeller University, Memorial Sloan Kettering Cancer Center and the New York Genome Center (NYGC), an unusual mutation has been found that is strongly linked to one such disease: a rare liver cancer that affects teens and young adults.

3 Mar 2014

Research: Beneficial and toxic roles of brain glycogen

In 2007, in an article published in Nature Neuroscience, scientists at the Institute for Research in Biomedicine (IRB Barcelona) headed by Joan Guinovart, an authority on glycogen metabolism, reported that in Lafora Disease (LD), a rare and fatal neurodegenerative condition that affects adolescents, neurons die as a result of the accumulation of glycogen-chains of glucose.

3 Mar 2014

Extract from amur cork tree shows promise in treating pancreatic cancer

The bark of the Amur cork tree (Phellodendron amurense) has traveled a centuries-long road with the healing arts. Now it is being put through its paces by science in the fight against pancreatic cancer, with the potential to make inroads against several more.

3 Mar 2014

Liver News and Research

Novel treatment strategy during transplantation surgery could spare patients from rejection

Promethera Biosciences, EMD Millipore partner to develop ready-to-use microfluidic perfusion liver assay

Skin cancer may increase risk of other cancers later in life

Exposure to UV light may exacerbate melanoma cells to creep outside blood vessels

Tissue analysis near tumors holds promise for earlier detection, new treatments

Boehringer Ingelheim reports results from SVR12 Phase 3 trial in patients with HCV/HIV co-infection

Low-dose oral interferon may reduce risk of HCV relapse in patients with mild liver fibrosis

New study uses Lumosity games to detect subtle cognitive impairments in patients with cirrhosis

Queensland scientists endeavor to stop spread of metastatic disease

Study: 55% of women are passive smokers due to exposure to tobacco smoke

Human Longevity, UC San Diego sign new collaborative research agreement

Metabolic profiling of liver cells suggests new treatments for cirrhosis patients

Protamine antidote can be effective in reversing low-molecular-weight heparin

Research provides insight into biologic mechanisms that individual cancer cells use to metastasize to brain

Costly new hepatitis C drug raises questions about who will pay

First Edition: March 3, 2014

Sunburn causes melanoma through direct and indirect processes

Researchers find unusual mutation strongly linked to rare liver cancer that affects teens

Research: Beneficial and toxic roles of brain glycogen

Extract from amur cork tree shows promise in treating pancreatic cancer

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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