Bone News and Research

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Insight into understanding IDH mediated disease

Agios Pharmaceuticals, the leading biopharmaceutical company focused on discovering and developing novel drugs in cancer metabolism, announced today the publication of a new study that provides further evidence of the link between a mutated metabolic enzyme and acute myeloid leukemia (AML), one of the most common types of leukemia in adults.

6 Jul 2012

Eltrombopag can raise blood cell levels in some people with severe aplastic anemia

Eltrombopag, a drug that was designed to stimulate production of platelets from the bone marrow and thereby improve blood clotting, can raise blood cell levels in some people with severe aplastic anemia who have failed all standard therapies.

5 Jul 2012

Scientists identify causative link between oncometabolite and onset of AML

A team of international scientists led by principal investigator Dr. Tak Mak at the Princess Margaret Cancer Centre, University Health Network, has identified a causative link between the product of a mutated metabolic enzyme and the onset of acute myeloid leukemia (AML), one of the most common types of leukemia in adults.

5 Jul 2012

Single dose breast cancer treatment helps forego 6-7 week radiation regimen

NewYork-Presbyterian Hospital/Weill Cornell Medical Center is the first and only hospital in the five boroughs of New York City to offer women with early stage breast cancer INTRABEAM radiotherapy, an innovative radiation treatment delivered in a single dose at the time of surgery.

5 Jul 2012

Italy's first successful pregnancy and delivery following transplantation of ovarian tissue

Although the first successful preservation of fertility from the freezing, thawing and grafting of ovarian tissue was reported eight years ago, the technique has remained experimental and confined to a few specialist centres. Now, with the announcement of a first pregnancy (and subsequent live birth) in Italy following the transplantation of ovarian tissue, there are indications that fertility preservation is moving into the mainstream of reproductive medicine and into a greater number of centres.

4 Jul 2012

Extensive health benefits associated with milk consumption

Milk is designed by nature as a complete food. Its composition has evolved with each mammalian species to reflect the particular environmental conditions and evolutionary demands of the young of that species. Humans have exploited this valuable resource since the dawn of the agricultural revolution through domestication of animals, in particular the cow. We have developed the technology to preserve milk during times of abundance and this has resulted in an array of foods now common in the diets of most human cultures.

4 Jul 2012

UCLA School of Dentistry receives NIH grant to create comprehensive research training program

In recent years, faculty at the UCLA School of Dentistry have been expanding the traditional boundaries of dentistry through groundbreaking multidisciplinary research that has led to major advances in everything from stem cell science to saliva diagnostics. Now, a $5 million grant from the National Institutes of Health's National Institute of Dental and Craniofacial Research will allow the school to continue these pioneering efforts by creating a comprehensive research training program to help cultivate the next generation of dentist-scientists and oral health researchers.

4 Jul 2012

Epigenetic changes due to methylation play a key role in altering genes in RA

It's not just our DNA that makes us susceptible to disease and influences its impact and outcome. Scientists are beginning to realize more and more that important changes in genes that are unrelated to changes in the DNA sequence itself - a field of study known as epigenetics - are equally influential.

4 Jul 2012

Investigators identify cell replacement/tissue repair potential in adult bone marrow stem cells

Researchers from the University of Maryland School of Maryland report promising results from using adult stem cells from bone marrow in mice to help create tissue cells of other organs, such as the heart, brain and pancreas - a scientific step they hope may lead to potential new ways to replace cells lost in diseases such as diabetes, Parkinson's or Alzheimer's.

4 Jul 2012

MedQIA develops bone scan analysis package within 510 (k) – cleared IBIS

MedQIA has developed a bone scan analysis package within our 510 (k) – cleared Imaging Biomarker Information System (IBIS). It includes a new automated technique for detecting lesions on bone scans that involves intensity normalization, thresholding, and connected-component analysis.

4 Jul 2012

Scientists reprogram amniotic fluid cells without introduction of extra genes

Stem cells found in amniotic fluid can be transformed into a more versatile state similar to embryonic stem cells, according to a study published today in the journal Molecular Therapy. Scientists from Imperial College London and the UCL Institute of Child Health succeeded in reprogramming amniotic fluid cells without having to introduce extra genes.

4 Jul 2012

Treating Sickle Cell Disease with L-Glutamine

By focusing on how best to help patients, researchers can sometimes find solutions that are much simpler than anticipated. That has been the guiding approach to our efforts to develop a treatment for sickle cell disease.

3 Jul 2012

Rodents may hold the key to long and active lifespan

Compared to the average three year life span of a common rat, the 10 to 30 year life of the naked mole rat, a subterranean rodent native to East Africa, is impressive. And compared to the human body, the body of this rodent shows little decline due to aging, maintaining high activity, bone health, reproductive capacity, and cognitive ability throughout its lifetime. Now a collaborative of researchers in Israel and the United States is working to uncover the secret to the small mammal's long - and active - lifespan.

3 Jul 2012

Osteoarthritis susceptibility: eight potential genes discovered

The largest genome-wide association study (GWAS) of osteoarthritis to date, published Online First in The Lancet, has uncovered eight new genetic variants or loci that appear to increase susceptibility to the most common form of arthritis, which affects about 40% of the world population older than 70 years. These findings bring the total number of osteoarthritis susceptibility genes isolated in European populations to 11.

3 Jul 2012

$Researchers report positive effects of ibuprofen on bone repair after fracture or surgery$

Researchers report positive effects of ibuprofen on bone repair after fracture or surgery

A study conducted at the University of Granada has demonstrated that ibuprofen -a non-steroidal anti-inflammatory drug (NSAID)- has beneficial effects on bone repair after a fracture or following bone surgery.

3 Jul 2012

Cutting funding for international food aid 'not the best answer' to saving money in U.S. budget

In order to "fill food gaps in the 70 most food deficient countries, ... the U.S., through the Food for Peace program and other food aid programs, provides approximately two million tons of American-grown food donations to 50 million starving people every year," James Henry, chair of USA Maritime, writes in an opinion piece in The Hill's "Congress Blog."

3 Jul 2012